Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: The involvement of cholinergic system

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dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridAAH-1448-2021tr_TR
dc.contributor.researcheridAAC-9702-2019tr_TR
dc.date.accessioned2021-06-30T12:30:05Z
dc.date.available2021-06-30T12:30:05Z
dc.date.issued2002-05
dc.description.abstractIntracerebroventricular (i.c.v.) administration of CDP-choline (0.25, 0.5, 1 and 2 mumol) induced prompt, dose- and time-dependent increase in blood pressure in normotensive rats. Equimolar dose of CDP-choline (1 mumol; i.c.v.) and choline (1 mumol; i.c.v.) caused similar increases in blood pressure while cytidine (1 mumol; i.c.v.) failed to produce any pressor effect. In haemorrhagic shock, CDPcholine (0.1, 0.25, 0.5 and 1 mumol; i.c.v.) increased blood pressure dose- and time-dependently. The complete reversal of hypotension was observed with the i.c.v. injection of CDP-choline (1 mumol) and choline (1 mumol). Cytidine (1 mumol; i.c.v.) produced small, but significant (P<0.05) increase in blood pressure in haemorrhaged rats. Dose-related bradycardia was observed with the injection of CDP-choline in normotensive rats, but the changes in heart rate were not significantly different (P>0.05) in hypotensive conditions. Choline levels in lateral cerebral ventricle and hypothalamus increased about nine- and five-fold, respectively, after CDP-choline (1 mumol) administration in normotensive rats. In haemorrhagic shock extracellular choline levels in hypothalamus increased sevenfold after an i.c.v. administration of CDP-choline (1 mumol). Hemicholinium-3 (20 mug; i.c.v.), a neuronal high affinity choline uptake blocker, and mecamylamine (50 mug; i.c.v.), nicotinic receptor antagonist, pretreatment abolished the pressor effect of CDP-choline in normal rats. The increase in blood pressure was also attenuated by atropine (10 mug; i.c.v.) pretreatment. Atropine blocked the bradycardic response observed after CDP-choline. In haemorrhaged rats, the pressor effect of CDP-choline was attenuated by hemicholinium-3 and mecamylamine while atropine failed to alter the pressor response to CDP-choline. i.c.v. CDPcholine increased plasma adrenaline and vasopressin levels in normal rats. Haemorrhage, itself, increased plasma catecholamines and vasopressin levels. CDP-choline (1 mumol) produced additional increases in the elevated plasma levels of these hormones. An alpha(1)-adrenoceptor blocker, prazosin (0.5 mg/kg; i.v.), or vasopressin V, receptor antagonist, [beta-mercapto, beta,beta-cyclopenta-methyl-enepropionyl(1), O-Me-Tyr(2)-Arg(8)]-vasopressin (10 mug/kg; i.v.), pretreatments partially blocked the pressor response to CDP-choline (1 mumol; i.c.v.). Simultaneous administration of these two antagonists completely blocked the pressor effect of CDP-choline in haemorrhagic shock. These results show that the exogenous administration of CDPcholine increases blood pressure and reverses hypotension in haemorrhagic shock. In normotensive conditions, increase in blood pressure appears to be due to the activation of both nicotinic and muscarinic central cholinergic receptors through the activation of presynaptic cholinergic mechanisms. In hypotensive rats, activation of nicotinic cholinergic receptors is solely involved in the pressor effect. Increase in plasma vasopressin and adrenaline mediates the pressor response of CDP-choline in both normotensive and hypotensive conditions.en_US
dc.identifier.citationSavcı, V. vd. (2002). "Cardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: the involvement of cholinergic system". Naunyn-Schmiedebergs Archives of Pharmakology, 365(5), 388-398.en_US
dc.identifier.endpage398tr_TR
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue5tr_TR
dc.identifier.pubmed12012025tr_TR
dc.identifier.scopus2-s2.0-0036255544tr_TR
dc.identifier.startpage388tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00210-002-0531-4
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00210-002-0531-4
dc.identifier.urihttp://hdl.handle.net/11452/20943
dc.identifier.volume365tr_TR
dc.identifier.wos000176069900008tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalNaunyn-Schmiedebergs Archives of Pharmacokogytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytidineen_US
dc.subjectCdp-cholineen_US
dc.subjectCholineen_US
dc.subjectCholinergicen_US
dc.subjectShocken_US
dc.subjectHaemorrhageen_US
dc.subjectVasopressinen_US
dc.subjectAdrenalineen_US
dc.subjectConscıous ratsen_US
dc.subjectNicotinic receptorsen_US
dc.subjectAcetylcholine-receptorsen_US
dc.subjectTyrosine-Hydroxylaseen_US
dc.subjectHemorrhagic-shocken_US
dc.subjectBlood-pressureen_US
dc.subjectNeuronsen_US
dc.subjectBrainen_US
dc.subjectHippocampalen_US
dc.subjectCiticoineen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleCardiovascular effects of intracerebroventricularly injected CDP-choline in normotensive and hypotensive animals: The involvement of cholinergic systemen_US
dc.typeArticle

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