Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis

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dc.contributor.authorEscribano, Damian
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorJoaquin Ceron, Jose
dc.contributor.authorPardo-Marin, Luis
dc.contributor.authorTorrecillas, Alejandro
dc.contributor.authorMartinez-Subiela, Silvia
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-9836-0749tr_TR
dc.contributor.researcheridV-5578-2017tr_TR
dc.contributor.scopusid36437200800tr_TR
dc.contributor.scopusid35944810500tr_TR
dc.date.accessioned2022-11-29T07:56:05Z
dc.date.available2022-11-29T07:56:05Z
dc.date.issued2016-10-10
dc.description.abstractThe aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed. APO-A1 was selected and an immunoturbidimetric assay was validated for its measurement in dogs. Significantly decreased concentrations of APO-A1 in dogs with leishmaniosis and a significant increase after a good response to the treatment were observed, suggesting that APO-A1 could be a potential biomarker of treatment monitoring with the advantages of an automated measurement.en_US
dc.description.sponsorshipRobles Chillida foundationen_US
dc.description.sponsorshipProgram for Research Groups of Excellence of the Seneca Foundation - 19894/GERM/15en_US
dc.description.sponsorshipJuan de la Cierva postdoctoral fellowship (Spanish Ministry of Economy and Competitiveness)en_US
dc.identifier.citationEscribano, D. vd. (2016). "Serum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosis". Comparative Immunology Microbiology and Infectious Diseases, 49, 82-87.en_US
dc.identifier.endpage87tr_TR
dc.identifier.issn0147-9571
dc.identifier.issn1878-1667
dc.identifier.pubmed27865270tr_TR
dc.identifier.scopus2-s2.0-84993970544tr_TR
dc.identifier.startpage82tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.cimid.2016.10.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0147957116300984
dc.identifier.urihttp://hdl.handle.net/11452/29618
dc.identifier.volume49tr_TR
dc.identifier.wos000390521800011tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalComparative Immunology, Microbiology and Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakTOVAG-2130032tr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunologyen_US
dc.subjectMicrobiologyen_US
dc.subjectVeterinary sciencesen_US
dc.subjectLeishmaniosisen_US
dc.subjectDogsen_US
dc.subjectApolipoprotein A1en_US
dc.subjectTreatment monitoringen_US
dc.subjectVisceral leishmaniasisen_US
dc.subjectProteinsen_US
dc.subjectIdentificationen_US
dc.subjectProteomicsen_US
dc.subjectDiagnosisen_US
dc.subject.emtreeAlpha 1 antitrypsinen_US
dc.subject.emtreeApolipoprotein A1en_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeHaptoglobinen_US
dc.subject.emtreeHemoglobin beta chainen_US
dc.subject.emtreeImmunoglobulin lambda chainen_US
dc.subject.emtreeMeglumineen_US
dc.subject.emtreeRetinol binding protein 4en_US
dc.subject.emtreeVitamin D binding proteinen_US
dc.subject.emtreeAllopurinolen_US
dc.subject.emtreeAntiprotozoal agenten_US
dc.subject.emtreeApolipoprotein A1en_US
dc.subject.emtreeMeglumine antimoniateen_US
dc.subject.emtreeOrganometallic compounden_US
dc.subject.emtreeProteomeen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeCanine leishmaniasisen_US
dc.subject.emtreeDrug responseen_US
dc.subject.emtreeLeishmaniasisen_US
dc.subject.emtreeLimit of detectionen_US
dc.subject.emtreeMass spectrometryen_US
dc.subject.emtreeMonitoringen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreeProteomicsen_US
dc.subject.emtreeTwo dimensional electrophoresisen_US
dc.subject.emtreeValidityen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDogen_US
dc.subject.emtreeLeishmaniasisen_US
dc.subject.emtreeTwo dimensional gel electrophoresisen_US
dc.subject.meshAllopurinolen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiprotozoal agentsen_US
dc.subject.meshApolipoprotein A-Ien_US
dc.subject.meshBiomarkersen_US
dc.subject.meshDogsen_US
dc.subject.meshElectrophoresis, gel, two-dimensionalen_US
dc.subject.meshLeishmaniasisen_US
dc.subject.meshMass spectrometryen_US
dc.subject.meshMeglumineen_US
dc.subject.meshOrganometallic compoundsen_US
dc.subject.meshProteomeen_US
dc.subject.scopusLeishmania Infantum; Dog; Psychodidaeen_US
dc.subject.wosImmunologyen_US
dc.subject.wosMicrobiologyen_US
dc.subject.wosVeterinary sciencesen_US
dc.titleSerum apolipoprotein-A1 as a possible biomarker for monitoring treatment of canine leishmaniosisen_US
dc.typeArticle
dc.wos.quartileQ4 (Immunology)en_US
dc.wos.quartileQ3 (Microbiology)en_US
dc.wos.quartileQ1 (Veterinary sciences)en_US

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