Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats

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dc.contributor.authorJochem, Jerzy
dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-5600-8162tr_TR
dc.contributor.researcheridAAG-6956-2021tr_TR
dc.contributor.scopusid57192959734tr_TR
dc.contributor.scopusid6603687024tr_TR
dc.date.accessioned2021-12-24T07:42:58Z
dc.date.available2021-12-24T07:42:58Z
dc.date.issued2009-06
dc.description.abstractHistamine, acting centrally as a neurotransmitter, evokes a reversal of haemorrhagic shock in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. In the present study, we demonstrate influences of cholinergic receptor antagonists on the central histamine-induced resuscitating action. Experiments were carried out in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg, resulting in the death of all control animals within 30 min. Histamine (100 nmol) administered intracerebroventricularly (icv) at 5 min of critical hypotension produced a long-lasting pressor effect with increases in heart rate and peripheral blood flows, and a 100% survival at 2 h. Mean arterial pressure and blood flow changes were almost completely blocked by nicotinic receptor antagonist mecamylamine (246.3 nmol; icv) and partially inhibited by muscarinic receptor blocker atropine sulphate (14.8 nmol; icv). Cholinergic receptor antagonists given alone in the control saline-treated groups did not affect cardiovascular parameters in the post-bleeding period. In conclusion, there are interactions between the histaminergic and cholinergic systems, with an involvement of both nicotinic and muscarinic receptors, in the central cardiovascular regulation in haemorrhagic hypotension in rats.en_US
dc.identifier.citationYalçın, M. vd. (2009). "Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats".Journal of Physiology and Pharmacology, 60(2), 133-137.en_US
dc.identifier.endpage137tr_TR
dc.identifier.issn08675910
dc.identifier.issue2tr_TR
dc.identifier.pubmed19617656tr_TR
dc.identifier.scopus2-s2.0-68049106138tr_TR
dc.identifier.startpage133tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/23540
dc.identifier.volume60tr_TR
dc.identifier.wos000267678000018tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherPolish Physiologicalen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Physiology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholinergic systemen_US
dc.subjectHaemorrhagic shocken_US
dc.subjectHistamineen_US
dc.subjectRatsen_US
dc.subjectEndogenous central histamineen_US
dc.subjectCentral cardiovascular regulationen_US
dc.subjectInjected cdp-cholineen_US
dc.subjectCholinomimetic drugsen_US
dc.subjectAnesthetized ratsen_US
dc.subjectNervous-systemen_US
dc.subjectBlood-pressureen_US
dc.subjectNitric-oxideen_US
dc.subjectShocken_US
dc.subjectActhen_US
dc.subjectPhysiologyen_US
dc.subject.emtreeAtropineen_US
dc.subject.emtreeHistamineen_US
dc.subject.emtreeMecamylamineen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCholinergic systemen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeHeart rateen_US
dc.subject.emtreeHemorrhagic hypotensionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMean arterial pressureen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePeripheral circulationen_US
dc.subject.emtreeRaten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAtropineen_US
dc.subject.meshBlood pressureen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshHeart rateen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHistamineen_US
dc.subject.meshHypotensionen_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMecamylamineen_US
dc.subject.meshMuscarinic antagonistsen_US
dc.subject.meshNicotinic antagonistsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, wistaren_US
dc.subject.meshReceptors, cholinergicen_US
dc.subject.meshRegional blood flowen_US
dc.subject.meshShock, hemorrhagicen_US
dc.subject.scopusHistamine H4 Receptors; Thioperamide; Chlorpheniramine Maleateen_US
dc.subject.wosPhysiologyen_US
dc.titleInvolvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in ratsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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