Influence of exercise intensify on the on- and off-transient kinetics of pulmonary oxygen uptake in humans

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dc.contributor.authorRossiter, Harry
dc.contributor.authorWard, Susan Ann
dc.contributor.authorWhipp, Brian J.
dc.contributor.buuauthorÖzyener, Fadıl
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4606-6596tr_TR
dc.contributor.researcheridAAH-1641-2021tr_TR
dc.date.accessioned2021-06-24T10:50:54Z
dc.date.available2021-06-24T10:50:54Z
dc.date.issued2001-06
dc.description.abstractThe maximal oxygen uptake ((V) over dot (O2,peak)) during dynamic muscular exercise is commonly taken as a crucial determinant of the ability to sustain high-intensity exercise. Considerably less attention, however, has been given to the rate at which (V) over dot (O2), increases to attain this maximum (or to its submaximal requirement), and even less to the kinetic features of the response following exercise.Six, healthy, male volunteers (aged 22 to 58 years), each performed 13 exercise tests: initial ramp-incremental cycle ergometry to the limit of tolerance and subsequently, on different days, three bouts of square-wave exercise each at moderate, heavy, very heavy and severe intensities. Pulmonary gas exchange variables were determined breath by breath throughout exercise and recovery from the continuous monitoring of respired volumes (turbine) and gas concentrations (mass spectrometer). For moderate exercise, the (V) over dot O-2, kinetics were well described by a simple mono-exponential function, following a short cardiodynamic phase, with the on- and off-transients having similar time constants (tau (1)); i.e. tau (1,on) averaged 33 +/- 16 s (+/- S.D.) and tau (1,off) 29 +/- 6 s. 4. The on-transient (V) over dot (O2) kinetics were more complex for heavy exercise. The inclusion of a second slow and delayed exponential component provided an adequate description of the response; i.e. tau (1,on) = 32 +/- 17 s and tau (2,on) = 170 +/- 49 s. The off-transient (V) over dot (O2) kinetics, however, remained mono-exponential (tau (1,off) = 42 +/- 11 s). 5. For very heavy exercise, the on-transient (V) over dot (O2), kinetics were also well described by a double exponential function (tau (1,on) = 34 +/- 11 s and tau (2,on) = 163 +/- 46 s). However, a double exponential, with no delay, was required to characterise the off-transient kinetics (i.e. tau (1,off) = 33 +/- 5 s and tau (2,off) = 460 +/- 123 s). 6. At the highest intensity (severe), the on-transient Tie, kinetics reverted to a mono-exponential profile (tau (1,on) = 34 +/- 7 s), while the off-transient kinetics retained a two-component form (tau (1,off) = 35 +/- 11 s and tau (2,off) = 539 +/- 379 s). 7. We therefore conclude that the kinetics of (V) over dot (O2) during dynamic muscular exercise are strikingly influenced by the exercise intensity, both with respect to model order and to dynamic asymmetries between the on- and off-transient responses.en_US
dc.identifier.citationRossiter, H. vd. (2001). "Influence of exercise intensify on the on- and off-transient kinetics of pulmonary oxygen uptake in humans". Journal of Physiology-London, 533(3), 891-902.tr_TR
dc.identifier.endpage902tr_TR
dc.identifier.issn0022-3751
dc.identifier.issue3tr_TR
dc.identifier.pubmed11410644tr_TR
dc.identifier.scopus2-s2.0-0035875401tr_TR
dc.identifier.startpage891tr_TR
dc.identifier.urihttps://doi.org/10.1111/j.1469-7793.2001.t01-1-00891.x
dc.identifier.urihttps://physoc.onlinelibrary.wiley.com/doi/10.1111/j.1469-7793.2001.t01-1-00891.x
dc.identifier.urihttp://hdl.handle.net/11452/20826
dc.identifier.volume533tr_TR
dc.identifier.wos000169800400023tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileytr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalJournal of Physiology-Londontr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiac-outputen_US
dc.subjectO-2 deficiten_US
dc.subjectMuscle-fibersen_US
dc.subjectGas-exchange kineticsen_US
dc.subjectCycle ergometer exerciseen_US
dc.subjectHeavy exerciseen_US
dc.subjectSlow componenten_US
dc.subjectVo2 kineticsen_US
dc.subjectSubmaximal exerciseen_US
dc.subjectRespiratory profileen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPhysiologyen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPhysiologyen_US
dc.titleInfluence of exercise intensify on the on- and off-transient kinetics of pulmonary oxygen uptake in humansen_US
dc.typeArticle
dc.wos.quartileQ1 (Physiology)en_US

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