Tear function and ocular surface findings in premature and term babies

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dc.contributor.authorGoto, Eiki
dc.contributor.authorMatsumoto, Yukihiro
dc.contributor.authorKojima, Takashi
dc.contributor.authorShimazaki, Jun
dc.contributor.authorTsubota, Kazuo
dc.contributor.buuauthorDoğru, Murat
dc.contributor.buuauthorKarakaya, Hatice
dc.contributor.buuauthorBaykara, Mehmet
dc.contributor.buuauthorÖzmen, Ahmet Tuncer
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.scopusid7006540932tr_TR
dc.contributor.scopusid6602509365tr_TR
dc.contributor.scopusid23093006700tr_TR
dc.contributor.scopusid6701399730tr_TR
dc.contributor.scopusid7003323615tr_TR
dc.date.accessioned2022-03-16T07:23:47Z
dc.date.available2022-03-16T07:23:47Z
dc.date.issued2004-05
dc.descriptionBu çalışma, 22 Mayıs 2003 tarihleri arasında Miami[Florida]’da düzenlenen 8. Annual Meeting of the International-Ocular-Surface-Society’da bildiri olarak sunulmuştur.tr_TR
dc.description.abstractObjective: To describe the ocular surface and tear function findings in premature and term babies. Design: Prospective, case-control study. Participants: Forty-eight eyes of 24 premature babies seen at the Department of Ophthalmology of Uludag University School of Medicine, Bursa, Turkey, from March 2002 through September 2002 and 50 eyes of 25 healthy term babies were studied. Intervention: The subjects underwent routine ophthalmic examinations; corneal sensitivity measurements; Schirmer test with anesthesia, with and without nasal stimulation; primary Jones test; fluorescein staining of the ocular surface; and conjunctival impression cytology. Main Outcome Measures: Premature and term babies were compared for corneal sensitivity, lacrimal drainage system patency, tear function and ocular surface staining parameters, goblet cell density, and squamous metaplasia grade. The relation of these parameters to the status of the ocular surface was also investigated. Results: Mean corneal sensitivity scores were 45 +/- 5.0 mm and 55 +/- 4.5 mm in the premature and term babies, respectively (P<0.001). Premature babies had a mean corneal fluorescein staining score of 1.5 +/- 0.25 points, compared with 0.22 +/- 0.28 points in the term babies (P<0.001). The mean Schirmer test scores without and with stimulation were 1.5 +/- 2.5 mm and 4.15 +/- 2.5 mm in the premature babies, respectively, compared with 15 +/- 3.5 mm and 18.75 +/- 4.5 mm in the term babies. The intragroup and intergroup Schirmer test scores were statistically significant (P<0.001). The primary Jones test was positive in 20.8% of the eyes in the premature babies, whereas it was positive in 84% of eyes in the term babies. The premature babies with positive primary Jones test results all had corneal epithelial defects or severe superficial punctuate keratopathy. Mean conjunctival impression cytology squamous metaplasia scores were 1.86 +/- 1.2 in the premature babies and 0.86 +/- 0.47 in the term babies (P<0.001). Mean goblet cell densities were 393 +/- 484 cells/mm(2) and 739 +/- 503 cells/mm(2) in the premature and term babies, respectively (P<0.001). Conclusion: Decreased corneal sensitivity, reduced tearing, and lacrimal drainage patency are important determinants of ocular surface disease in premature infants. Premature newborns with low Schirmer test scores and a patent lacrimal system may experience corneal and conjunctival epithelial problems and should be carefully checked for the presence of dry eye complications.en_US
dc.description.sponsorshipInt Ocular Surface Socen_US
dc.identifier.citationDoğru, M. vd. (2004). “Tear function and ocular surface findings in premature and term babies”. Ophthalmology, 111(5), 901-905.en_US
dc.identifier.endpage905tr_TR
dc.identifier.issn0161-6420
dc.identifier.issue5tr_TR
dc.identifier.pubmed15121366tr_TR
dc.identifier.scopus2-s2.0-2342640990tr_TR
dc.identifier.startpage901tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ophtha.2003.07.017
dc.identifier.urihttps://keio.pure.elsevier.com/en/publications/tear-function-and-ocular-surface-findings-in-premature-and-term-b
dc.identifier.urihttp://hdl.handle.net/11452/25064
dc.identifier.volume111tr_TR
dc.identifier.wos000221231500009tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.indexed.wosCPCISen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalOphthalmologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararasıtr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOphthalmologyen_US
dc.subjectImpression cytologyen_US
dc.subjectNewbornsen_US
dc.subjectInfantsen_US
dc.subjectPretermen_US
dc.subject.emtreeFluoresceinen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell densityen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeConjunctivaen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCornea diseaseen_US
dc.subject.emtreeCornea epitheliumen_US
dc.subject.emtreeCornea sensibilityen_US
dc.subject.emtreeCytologyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFluorescence analysisen_US
dc.subject.emtreeGoblet cellen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeKeratopathyen_US
dc.subject.emtreeLacrimationen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOphthalmologyen_US
dc.subject.emtreePrematurityen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeSchirmer testen_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSquamous cell metaplasiaen_US
dc.subject.emtreeTear flowen_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshConjunctival diseasesen_US
dc.subject.meshCorneal diseasesen_US
dc.subject.meshDry eye syndromesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluoresceinen_US
dc.subject.meshFluorophotometryen_US
dc.subject.meshGestational ageen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshInfant, premature, diseasesen_US
dc.subject.meshLacrimal apparatus diseasesen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshStaining and labelingen_US
dc.subject.meshTearsen_US
dc.subject.scopusKeratoconjunctivitis Sicca; Animals; Tearsen_US
dc.subject.wosOphthalmologyen_US
dc.titleTear function and ocular surface findings in premature and term babiesen_US
dc.typeArticle
dc.typeProceedings Paper
dc.wos.quartileQ1en_US

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