Comparison of the effects of prednisolon, danazol and testosteron propionat therapy in dogs with immune mediated hemolytic anemia and thrombocytopenia

dc.contributor.buuauthorŞentürk, Sezgin
dc.contributor.buuauthorTemizel, Mutlu
dc.contributor.buuauthorCihan, Hüseyin
dc.contributor.buuauthorAytuğ, Nilüfer
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.date.accessioned2020-11-23T10:22:07Z
dc.date.available2020-11-23T10:22:07Z
dc.date.issued2010-04-05
dc.description.abstractThe purpose of the study was to determine and compare the effectiveness of Prednisolon, Danazol and Testosteron propionate in the treatment of 45 dogs with IMHA and IMT. All dogs were selected from dogs diagnosed IMHA and IMT at the Uludag University Faculty of Veternary Medicine, Internal Medicine Clinic, 2003 and 2007 years comprised the animal population of the study. Clinical, biochemical and hematological examination were performed to all dogs during 3 weeks. Dogs in the present study were divided into 3 groups which consisted of 15 dogs. Group I received prednisolone at immunosuppressive doses. Group II received Danazol and also group III received testosterone propionate. The mainly manifesting disturbances in presentation were exercise intolerans, pale mucous membranes, icterus, hemoglobinuria, petechiae and ecchymosis, melena and epistaxis. Hemoglobin and hematocrit levels were significantly higher in group I and II compared with group III at the end of treatment (P=0.05). Thrombocyte counts were within normal reference limits in group I and II at the end of the therapy. In conclusion in this study, despite the normal response to conventional treatment, prednisolone therapy and danazol as synthetic androgen, it was deterimined that there were no anticipated effects by testosterone propionate for treatment of AIHA in dogs.en_US
dc.description.abstractBu çalışma Prednisolon, Danazol ve Testosteron propionate’ın İmmun ilişkili anemi (İHA) ve immun ilişkili trombositopenili (İT) 45 köpeğin tedavisindeki etkinliğinin belirlenmesi ve karşılatırılması amacıyla yapıldı. Bütün köpekler 2003–2007 yılları arasında Uludağ Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniğiinde İHA ve İT taısı konan köpekler arasından seçildi. Bütün köpeklere ait klinik, hematolojik ve biyokimyasal muayeneler 3 hafta boyunca yapıldı. Çalışmada kullanılan köpekler her biri 15 köpekten oluşan 3 gruba ayrıldı; 1. Gruba immunsupresif dozajda prednisolone uygulandı. 2. Gruba Danazol ve 3. Gruba testoterone propionate uygulandı. Köpeklerde ilk muayene sonuçları arasında solgun mukoz membranlar, ikterus, hemoglobinüri, peteşi, ekimoz, melena ve epistaksis saptandı. Hemoglobin ve hematkrit düzeyleri tedavi sonunda 3. grup hayvanlara göre 1. ve 2. gruptaki hayvanlarda istatistiki olarak daha yüksek olarak saptandı (P=0.05) Trombosit sayısı tedavinin sonunda 1. ve 2. Gruptaki hayvanlarda normal sınırlar içindeydi. Sonuç olarak, prednisolone ve danazol uygulamaları tedavide etkili olurken, testosterone propionate tedavisde etkili olmadığı belirlenmiştir.tr_TR
dc.identifier.citationŞentürk, S. vd. (2010). "Comparison of the effects of prednisolon, danazol and testosteron propionat therapy in dogs with ımmune mediated hemolytic anemia and thrombocytopenia". Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 29(2), 57-63.tr_TR
dc.identifier.endpage63tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue2tr_TR
dc.identifier.startpage57tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/144406
dc.identifier.urihttp://hdl.handle.net/11452/14067
dc.identifier.volume29tr_TR
dc.language.isoenen
dc.publisherUludağ Üniversitesitr_TR
dc.relation.bap2002/79tr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnemiaen_US
dc.subjectAnemitr_TR
dc.subjectPlateleten_US
dc.subjectErythrocyteen_US
dc.subjectCorticosteroidsen_US
dc.subjectAndrogenen_US
dc.subjectEritrosittr_TR
dc.subjectKortikosteroidtr_TR
dc.subjectAndrojentr_TR
dc.titleComparison of the effects of prednisolon, danazol and testosteron propionat therapy in dogs with immune mediated hemolytic anemia and thrombocytopeniaen_US
dc.title.alternativeİmmun ilişkili anemi ve immun ilişkili trombositopenili (it) köpeklerde prednisolon, danazol ve testosteron propionate’ın ekinliğinin karşılatırılmasıtr_TR
dc.typeArticleen_US

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