Nosocomial candidemia in adults: Risk and prognostic factors

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dc.contributor.buuauthorGürcüoğlu, Emel
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorEner, Beyza
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorSınırtaş, Melda
dc.contributor.buuauthorAkçağlar, Sevim
dc.contributor.buuauthorYılmaz, Emel
dc.contributor.buuauthorEvci, Canan
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.orcid0000-0002-4803-8206tr_TR
dc.contributor.orcid0000-0002-4759-9634tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridAAH-5180-2021tr_TR
dc.contributor.researcheridAAG-8523-2021tr_TR
dc.contributor.scopusid24502872100tr_TR
dc.contributor.scopusid57207553671tr_TR
dc.contributor.scopusid15053025300tr_TR
dc.contributor.scopusid15832295800tr_TR
dc.contributor.scopusid6505818048tr_TR
dc.contributor.scopusid6506194958tr_TR
dc.contributor.scopusid22037135100tr_TR
dc.contributor.scopusid22034011200tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.date.accessioned2022-04-11T13:44:54Z
dc.date.available2022-04-11T13:44:54Z
dc.date.issued2010-12
dc.description.abstractObjective of the study. - Determination of the risk and prognostic factors for candidemias that develop in adult patients (in a general hospital patient population, intensive care unit [ICU] patients and patients with solid organ malignancy). Patients. - The risk factors for candidemia were investigated in 256 adult patients (>= 18 years old). Patients and methods. - The risk and prognostic factors for candidemia were investigated in adult patients using a matched case-control design. Results. - We found that a total of 457 adult patients developed nosocomial candidemia in our hospital over the 12-year study period. Candida albicans (46.8%) was the most common etiological agent in candidemia, whereas C. parapsilosis (27%) was isolated as the second most frequent species. The ratio of C. glabrata was 3.8%. The risk factors for candidemia were investigated in 256 patients for whom full medical record information was available. Total parenteral nutrition (TPN) (OR 1.718; 95% CI 1.139-2.594, P = 0.01), antacid use (OR 1.841; 95% CI 1.239-2.735, P = 0.003) and candiduria (OR 2.095; 95% CI 1.213-3.617, P = 0.008) were detected as independent risk factors for candidemia among all affected patients. Removal of the central venous catheter (OR 1.976; 95% CI 1.219-3.202, P = 0.006) was protective against mortality. Conclusion. - Candiduria, and use of TPN were the most frequently encountered independent risk factors in almost all patient groups in our study as well as in other studies on this topic, so they should be taken into account in the evaluation of patients with suspicion of candidemia.en_US
dc.identifier.citationGürcüoğlu, E. vd. (2010). "Nosocomial candidemia in adults: Risk and prognostic factors". Journal de Mycologie Medicale, 20(4), 269-278.en_US
dc.identifier.endpage278tr_TR
dc.identifier.issn1156-5233
dc.identifier.issn1773-0449
dc.identifier.issue4tr_TR
dc.identifier.scopus2-s2.0-78649915273tr_TR
dc.identifier.startpage269tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.mycmed.2010.07.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1156523310000806
dc.identifier.urihttp://hdl.handle.net/11452/25710
dc.identifier.volume20tr_TR
dc.identifier.wos000285677900002tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.journalJournal de Mycologie Medicaleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNosocomial candidemiaen_US
dc.subjectMortalityen_US
dc.subjectRisk factorsen_US
dc.subjectEpidemiologyen_US
dc.subjectMycologyen_US
dc.subjectCandida albicansen_US
dc.subject.emtreeAntacid agenten_US
dc.subject.emtreeFluconazoleen_US
dc.subject.emtreeAbdominal surgeryen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeArtificial ventilationen_US
dc.subject.emtreeCandida albicansen_US
dc.subject.emtreeCandida glabrataen_US
dc.subject.emtreeCandida parapsilosisen_US
dc.subject.emtreeCandidemiaen_US
dc.subject.emtreeCandiduriaen_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeCatheter removalen_US
dc.subject.emtreeCentral venous catheteren_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeErythrocyte transfusionen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFungus isolationen_US
dc.subject.emtreeHospital infectionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInfection risken_US
dc.subject.emtreeIntensive care uniten_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMalignant neoplastic diseaseen_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreeNasogastric tubeen_US
dc.subject.emtreeNeutropeniaen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeTotal parenteral nutritionen_US
dc.subject.scopusCandidemia; Invasive Candidiasis; Candida Parapsilosisen_US
dc.subject.wosMycologyen_US
dc.titleNosocomial candidemia in adults: Risk and prognostic factorsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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