Increased risk of chronic hepatitis in children with cancer

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dc.contributor.buuauthorSevinir, Betül Berrin
dc.contributor.buuauthorMeral, Adalet Güneş
dc.contributor.buuauthorGünay, Ünsal
dc.contributor.buuauthorÖzkan, Tanju
dc.contributor.buuauthorÖzuysal, Sema
dc.contributor.buuauthorSınırtaş, Melda
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridAAH-1570-2021tr_TR
dc.contributor.scopusid6603199915tr_TR
dc.contributor.scopusid6602571317tr_TR
dc.contributor.scopusid6603885274tr_TR
dc.contributor.scopusid7004474005tr_TR
dc.contributor.scopusid56616314600tr_TR
dc.contributor.scopusid6505818048tr_TR
dc.date.accessioned2021-09-06T12:43:17Z
dc.date.available2021-09-06T12:43:17Z
dc.date.issued2003-02
dc.description.abstractBackground. There is a risk of viral hepatitis for children with cancer. Both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in countries with high prevalence cause major problems in the management of cancer patients. in this study, we evaluated the incidence and chronicity of HBV and HCV infections in children with malignant diseases receiving chemotherapy. Procedure. One hundred ninety-eight children with cancer (mean age=7.5 +/- 2.5 years) and 100 healthy children as a control group were screened for HBV and HCV. Liver function tests, the number of transfusions, HBV and HCV serology were regularly monitored. In seropositive children, HBV-DNA and HCV-RNA were measured. Chronic hepatitis was defined as having an alanine aminotransferase (ALT) level three times of upper normal limit, positive HBV and HCV antigenemia for longer than 6 months. Liver biopsies were performed in all children with chronic hepatitis. The relationship between the chronic hepatitis and study parameters was statistically analyzed. Results. HBsAg positivity, anti-HCV, and mixed (HBV and HCV) infection were found in 11.6, 5.5, 2% of children, respectively. Most HBV infected children developed chronic hepatitis (48%) while 26 and 21.7% became carriers and immune, respectively. One died of acute fulminant HBV hepatitis. Of HCV infected children, 63.6% also had positive HCV-RNA. Four children with mixed infection (100%) all progressed to chronic hepatitis. In this setting, chronic hepatitis was observed in 22 of 38 infected children (57.8%). The majority had leukemia and lymphoma. Children with HBsAg antigenemia developed chronic hepatitis in shorter time than HCV positive children (median 13 months vs. 51 months, P<0.001). Conclusion. We observed an increased incidence of chronic hepatitis and even mortality due to HBV infection. This suggests that HBV and HCV infections are serious causes of morbidity and mortality in children with cancer.en_US
dc.identifier.citationSevinir, B. vd. (2003). “Increased risk of chronic hepatitis in children with cancer”. Medical and Pediatric Oncology, 40(2), 104-110.tr_TR
dc.identifier.endpage110tr_TR
dc.identifier.issn0098-1532
dc.identifier.issue2tr_TR
dc.identifier.pubmed12461794tr_TR
dc.identifier.scopus2-s2.0-0037291523tr_TR
dc.identifier.startpage104tr_TR
dc.identifier.urihttps://doi.org/10.1002/mpo.10090
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/mpo.10090
dc.identifier.urihttp://hdl.handle.net/11452/21710
dc.identifier.volume40tr_TR
dc.identifier.wos000179873900006tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.journalMedical and Pediatric Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectPediatricsen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Cen_US
dc.subjectChronic hepatitisen_US
dc.subjectChildhood canceren_US
dc.subjectAcute lymphoblastic-leukemiaen_US
dc.subjectC virus-infectionen_US
dc.subjectAcute myeloid-leukemiaen_US
dc.subjectChronic liver-diseasetr_TRen_US
dc.subjectLong-term remissionen_US
dc.subjectNatural-historyen_US
dc.subjectViral-hepatitisen_US
dc.subjectChildhooden_US
dc.subjectChemotherapyen_US
dc.subjectEpidemiologyen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeBleomycinen_US
dc.subject.emtreeDoxorubicinen_US
dc.subject.emtreeHepatitis B surface antigenen_US
dc.subject.emtreeVincristineen_US
dc.subject.emtreeVirus DNAen_US
dc.subject.emtreeVirus RNAen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeCancer chemotherapyen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeChildhood canceren_US
dc.subject.emtreeChronic hepatitisen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHepatitis B virusen_US
dc.subject.emtreeHepatitis C virusen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInfanten_US
dc.subject.emtreeLeukemiaen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeLiver function testen_US
dc.subject.emtreeLymphomaen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMorbidityen_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreePriority journalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntineoplastic combined chemotherapy protocolsen_US
dc.subject.meshBleomycinen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshDacarbazineen_US
dc.subject.meshDNA, viralen_US
dc.subject.meshDoxorubicinen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepacivirusen_US
dc.subject.meshHepatitis B virusen_US
dc.subject.meshHepatitis B, chronicen_US
dc.subject.meshHepatitis C, chronicen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, newbornen_US
dc.subject.meshLiver function testsen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshRNA, viralen_US
dc.subject.meshVinblastineen_US
dc.subject.scopusHepatitis C; Vertical Infectious Disease Transmission; Ribavirinen_US
dc.subject.wosOncologyen_US
dc.subject.wosPediatricsen_US
dc.titleIncreased risk of chronic hepatitis in children with canceren_US
dc.typeArticle
dc.wos.quartileQ1 (Pediatrics)en_US
dc.wos.quartileQ3 (Oncology)en_US

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