Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy

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dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.buuauthorSavcı, Vahide
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridAAG-8716-2019tr_TR
dc.date.accessioned2021-09-13T12:07:27Z
dc.date.available2021-09-13T12:07:27Z
dc.date.issued1997
dc.description.abstract1: The effect of centrally administered choline on blood pressure was investigated in rats made hypotensive by chemical sympathectomy. Chemical sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg(-1) of 6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of choline (50-150 mu g) 2 h after 6-OHDA treatment increased blood pressure and reversed the hypotension in a dose-dependent mariner without affecting heart rate. The presser response was associated with an increase in plasma vasopressin levels. 2: Pretreatment of rats with the nicotinic receptor antagonist, mecamylamine (50 mu g, i.c.v.), but not the muscarinic receptor antagonist atropine (10 mu g, i.c.v.), blocked both the presser and vasopressin responses to choline (150 mu g). Pretreatment of rats with hemicholinium-3 (HC-3), a high affinity choline uptake inhibitor, greatly attenuated the presser response to i.c.v. choline (150 mu g). 3: The vasopressin V1 receptor antagonist, (beta-mercapto-beta,beta-cyclopentamethylenepropionyl-O- Me-Try,Arg)-vasopressin (10 mu g kg(-1); i.v.), given 5 min after i.c.v. choline, decreased the blood pressure but failed to return it to the pre-choline levels. Prazosine (0.5 mg kg(-1); i.p.), an antagonist of a-adrenoceptors, also decreased blood pressure. Administration of both antagonists together eliminated the presser response to choline, and the blood pressure was reduced further to below the pre-choline levels. 4: It is concluded that i.c.v. choline can increase blood pressure in rats made hypotensive by acute chemical sympathectomy through the activation of central nicotinic receptors by presynaptic mechanisms. An elevation in plasma levels of both vasopressin and catecholamines (possibly released from the adrenal medulla) is involved in the pressor response to choline.en_US
dc.identifier.citationGürün, M. S. vd. (1997). "Intracerebroventricular choline reverses hypotension induced by acute chemical sympathectomy". Journal of Autonomic Pharmacology, 17(3), 155-163.en_US
dc.identifier.endpage163tr_TR
dc.identifier.issn0144-1795
dc.identifier.issue3tr_TR
dc.identifier.pubmed9278775tr_TR
dc.identifier.scopus2-s2.0-0030743642tr_TR
dc.identifier.startpage155tr_TR
dc.identifier.urihttps://doi.org/10.1046/j.1365-2680.1997.00450.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2680.1997.00450.x
dc.identifier.urihttp://hdl.handle.net/11452/21909
dc.identifier.volume17tr_TR
dc.identifier.wosA1997XP79100003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBlackwell Scienceen_US
dc.relation.journalJournal of Autonomic Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectPharmacology & pharmacyen_US
dc.subjectCentral nervous-systemen_US
dc.subjectHemorrhagic-shocken_US
dc.subjectTyrosine-hydroxylaseen_US
dc.subjectBlood-pressureen_US
dc.subjectRat striatumen_US
dc.subjectAcetylcholine-releaseen_US
dc.subjectVasopressin releaseen_US
dc.subjectConscious ratsen_US
dc.subjectAngiotensin-IIen_US
dc.subjectNeuronsen_US
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholineen_US
dc.subject.wosNeurosciencesen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.titleIntracerebroventricular choline reverses hypotension induced by acute chemical sympathectomyen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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