Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases
dc.contributor.buuauthor | Tufan, Ayşe Nur | |
dc.contributor.buuauthor | Sağ, Saim | |
dc.contributor.buuauthor | Öksüz, Ferhat | |
dc.contributor.buuauthor | Ermurat, Selime | |
dc.contributor.buuauthor | Coşkun, Belkıs Nihan | |
dc.contributor.buuauthor | Güllülü, Mustafa | |
dc.contributor.buuauthor | Budak, Ferah | |
dc.contributor.buuauthor | Baran, İbrahim | |
dc.contributor.buuauthor | Pehlivan, Yavuz | |
dc.contributor.buuauthor | Dalkılıç, Ediz | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-0298-4157 | tr_TR |
dc.contributor.orcid | 0000-0001-8404-8252 | tr_TR |
dc.contributor.researcherid | AAG-7155-2021 | tr_TR |
dc.contributor.researcherid | AAW-9185-2020 | tr_TR |
dc.contributor.researcherid | F-4657-2014 | tr_TR |
dc.contributor.researcherid | AAG-8227-2021 | tr_TR |
dc.contributor.scopusid | 56076552900 | tr_TR |
dc.contributor.scopusid | 12140008100 | tr_TR |
dc.contributor.scopusid | 56016440100 | tr_TR |
dc.contributor.scopusid | 55371331300 | tr_TR |
dc.contributor.scopusid | 55646165400 | tr_TR |
dc.contributor.scopusid | 6602684544 | tr_TR |
dc.contributor.scopusid | 6701913697 | tr_TR |
dc.contributor.scopusid | 35572557400 | tr_TR |
dc.contributor.scopusid | 57220381538 | tr_TR |
dc.contributor.scopusid | 6506739457 | tr_TR |
dc.date.accessioned | 2023-01-05T06:14:38Z | |
dc.date.available | 2023-01-05T06:14:38Z | |
dc.date.issued | 2016-05-03 | |
dc.description.abstract | Patients with connective tissue diseases (CTDs) may have prolonged corrected QT interval which indicates increased risk for ventricular arrhythmias. However, a more sensitive measure of ventricular repolarization, T-peak-to-end (Tpe) interval, has not been studied in CTDs. We aimed to investigate the relationship between ventricular repolarization abnormalities and anti-Ro52-positivity in subjects with connective tissue diseases (CTDs). We enrolled patients with anti-Ro52-positive CTDs, ANA-positive CTDs, and healthy subjects in this cross-sectional study. We excluded conditions potentially affecting the QT interval. We compared the ECG measures between the groups and performed analyses to define factors associated with ventricular repolarization measures. 15 ANA and anti-Ro52-positive, 39 ANA-positive and anti-Ro52-negative, and 22 healthy subjects were enrolled. None of the subjects had rhythm or conduction disturbances. Corrected QT intervals were similar between the groups. Tpe (84, 77.3, and 69.4 msn, respectively) and QT-dispersion (40, 27.2, and 20.1 msn, respectively) were higher in anti-Ro52-positive subjects compared with the ANA-positive and healthy subjects. Anti-Ro52 titers were correlated with Tpe and QT-dispersion (r = 0.52 and p < 0.001 for each). ANA and anti-Ro52-positivity were independently associated with higher Tpe (OR = 7.7, p = 0.001 and OR = 6.9, p = 0.001, respectively), corrected Tpe (OR = 11.3, p = 0.001 and OR = 8.4, p = 0.003, respectively), QT dispersion (OR = 7, p = 0.008 and OR = 13, p < 0.001, respectively), and QTc dispersion (OR = 9.1, p = 0.001 and OR = 14.1, p < 0.001, respectively). This study provides evidence that ANA positivity, especially when concomitant anti-Ro52-positivity is present, significantly deteriorates ventricular repolarization. The aforementioned ventricular repolarization abnormalities may render these subjects susceptible to serious rhythm or conduction disorders in the setting of predisposing conditions. | en_US |
dc.description.sponsorship | Bursa Böbrek Vakfı | tr_TR |
dc.identifier.citation | Tufan, A. N. vd. (2017). ''Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases''. Rheumatology International, 37(1), 67-73. | en_US |
dc.identifier.endpage | 73 | tr_TR |
dc.identifier.issn | 0172-8172 | |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.pubmed | 27193468 | tr_TR |
dc.identifier.scopus | 2-s2.0-84976621858 | tr_TR |
dc.identifier.startpage | 67 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00296-016-3488-1 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00296-016-3488-1 | |
dc.identifier.uri | 1437-160X | |
dc.identifier.uri | http://hdl.handle.net/11452/30265 | |
dc.identifier.volume | 37 | tr_TR |
dc.identifier.wos | 000392329100009 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | Rheumatology International | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Rheumatology | en_US |
dc.subject | Anti-Ro52 | en_US |
dc.subject | Arrhythmia | en_US |
dc.subject | Connective tissue disease | en_US |
dc.subject | Tpeak-tend | en_US |
dc.subject | Ventricular repolarization | en_US |
dc.subject | Systemic-lupus-erythematosus | en_US |
dc.subject | Corrected qt interval | en_US |
dc.subject | Congenital heart-block | en_US |
dc.subject | Cardiac autonomic dysfunction | en_US |
dc.subject | Tp-e/qt ratio | en_US |
dc.subject | Rheumatoid-arthritis | en_US |
dc.subject | Ro/ssa antibodies | en_US |
dc.subject | Atrioventricular-block | en_US |
dc.subject | Ssa/ro antibodies | en_US |
dc.subject | Ro antibodies | en_US |
dc.subject.emtree | Antinuclear antibody | en_US |
dc.subject.emtree | Ro antibody | en_US |
dc.subject.emtree | Autoantibody | en_US |
dc.subject.emtree | Ribonucleoprotein | en_US |
dc.subject.emtree | SS-A antigen | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Antibody titer | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Clinical assessment | en_US |
dc.subject.emtree | Connective tissue disease | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Cross-sectional study | en_US |
dc.subject.emtree | Electrocardiogram | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Heart muscle conduction disturbance | en_US |
dc.subject.emtree | Heart repolarization | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | QT dispersion | en_US |
dc.subject.emtree | QTc interval | en_US |
dc.subject.emtree | Serology | en_US |
dc.subject.emtree | T peak to end interval | en_US |
dc.subject.emtree | Connective tissue disease | en_US |
dc.subject.emtree | Electrocardiography | en_US |
dc.subject.emtree | Heart arrhythmia | en_US |
dc.subject.emtree | Heart muscle conduction system | en_US |
dc.subject.emtree | Immunology | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Pathophysiology | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Arrhythmias, cardiac | en_US |
dc.subject.mesh | Autoantibodies | en_US |
dc.subject.mesh | Connective tissue diseases | en_US |
dc.subject.mesh | Cross-sectional studies | en_US |
dc.subject.mesh | Electrocardiography | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Heart conduction system | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Ribonucleoproteins | en_US |
dc.subject.scopus | Neonatal Systemic Lupus Erythematosus; Congenital Heart Block; Pregnancy | en_US |
dc.subject.wos | Rheumatology | en_US |
dc.title | Prolonged Tpeak-Tend interval in anti-Ro52 antibody-positive connective tissue diseases | en_US |
dc.type | Article |
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