Effects of capsaicin on nitric oxide synthase isoforms in prepubertal rat ovary

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dc.contributor.authorAltunbaş, Korhan
dc.contributor.authorTütüncü, Şerife
dc.contributor.authorÖzden, Osman
dc.contributor.authorSevimli, Alper
dc.contributor.buuauthorZik, Berrin
dc.contributor.buuauthorPeker, Sabire
dc.contributor.buuauthorAkkoç, Cansel Güzin Özgüden
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Histoloji-Embriyoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridF-2822-2017tr_TR
dc.contributor.researcheridAAH-9810-2021tr_TR
dc.contributor.scopusid6507763192tr_TR
dc.contributor.scopusid55109615900tr_TR
dc.contributor.scopusid36138936300tr_TR
dc.date.accessioned2022-05-13T13:08:42Z
dc.date.available2022-05-13T13:08:42Z
dc.date.issued2012-04
dc.description.abstractNitric oxide (NO) has emerged as an important intra-ovarian regulatory factor. We investigated effects of low dose capsaicin (CAP) treatment on the different NOS isoforms in prepubertal rat ovaries. Fifteen 21-day-old female Sprague-Dawley rats were divided randomly into three groups. The first group received no treatment, the second group received 0.5 mg/kg/day CAP dissolved in the vehicle, and the third group was treated with the vehicle only. The animals were euthanized by ether inhalation after 15 days and their ovaries were excised. Ovaries were fixed in 10% neutral buffered formalin and embedded in paraffin. Sections were processed for standard immunohistochemistry using the labeled streptavidin-biotin technique for expression of nNOS, eNOS and iNOS. We demonstrated that CAP induced expression of NOS isotypes including eNOS, iNOS and nNOS in prepubertal rat ovaries. CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.en_US
dc.identifier.citationZik, B. vd. (2012). "Effects of capsaicin on nitric oxide synthase isoforms in prepubertal rat ovary". Biotechnic & Histochemistry, 87(3), 218-225.en_US
dc.identifier.endpage225tr_TR
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3tr_TR
dc.identifier.pubmed21955128tr_TR
dc.identifier.scopus2-s2.0-84858591876tr_TR
dc.identifier.startpage218tr_TR
dc.identifier.urihttps://doi.org/10.3109/10520295.2011.608716
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/10520295.2011.608716
dc.identifier.urihttp://hdl.handle.net/11452/26463
dc.identifier.volume87tr_TR
dc.identifier.wos000301530000009tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.bapV-2008/66tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiotechnology & applied microbiologyen_US
dc.subjectCell biologyen_US
dc.subjectCapsaicinen_US
dc.subjecteNOSen_US
dc.subjectiNOSen_US
dc.subjectnNOSen_US
dc.subjectOvarian folliclesen_US
dc.subjectFollicular developmenten_US
dc.subjectSmooth-muscleen_US
dc.subjectSubstance-pen_US
dc.subjectExpressionen_US
dc.subjectCellsen_US
dc.subjectLocalizationen_US
dc.subjectOvulationen_US
dc.subjectProgesteroneen_US
dc.subjectGonadotropinen_US
dc.subjectSecretionen_US
dc.subjectAnimaliaen_US
dc.subjectRattusen_US
dc.subject.emtreeCapsaicinen_US
dc.subject.emtreeEndothelial nitric oxide synthaseen_US
dc.subject.emtreeInducible nitric oxide synthaseen_US
dc.subject.emtreeNeuronal nitric oxide synthaseen_US
dc.subject.emtreeNitric oxide synthaseen_US
dc.subject.emtreeNos1 protein, raten_US
dc.subject.emtreeNos2 protein, raten_US
dc.subject.emtreeNos3 protein, raten_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeEnzymologyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHistologyen_US
dc.subject.emtreeImmunohistochemistryen_US
dc.subject.emtreeInnervationen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeNerve endingen_US
dc.subject.emtreeOvaryen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSensory nerve cellen_US
dc.subject.emtreeSprague dawley raten_US
dc.subject.meshAnimalsen_US
dc.subject.meshCapsaicinen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNerve endingsen_US
dc.subject.meshNeurons, afferenten_US
dc.subject.meshNitric oxide synthaseen_US
dc.subject.meshNitric oxide synthase type Ien_US
dc.subject.meshNitric oxide synthase type IIen_US
dc.subject.meshNitric oxide synthase type IIIen_US
dc.subject.meshOvaryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.scopusMaturation-Promoting Factor; Oocytes; NG-nitroarginine Methyl Esteren_US
dc.subject.wosBiotechnology & applied microbiologyen_US
dc.subject.wosCell biologyen_US
dc.titleEffects of capsaicin on nitric oxide synthase isoforms in prepubertal rat ovaryen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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