Postischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flaps

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dc.contributor.buuauthorAkın, Selçuk
dc.contributor.buuauthorÖzcan, Mesut
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-1683-0722tr_TR
dc.contributor.researcheridAAH-5064-2021tr_TR
dc.contributor.scopusid7005263372tr_TR
dc.contributor.scopusid7102067678tr_TR
dc.date.accessioned2021-12-07T06:50:53Z
dc.date.available2021-12-07T06:50:53Z
dc.date.issued1998
dc.description.abstractThis study investigated the possible effect of hydroxyethyl starch (HAES) as a postischemic perfusion washout on survival of skin flaps. Forty-eight, male, Sprague-Dawley rats were used in this experiment. A 4x6 cm unilateral island skin flap based on the superficial inferior epigastric artery and vein was raised. The femoral neurovascular bundle supplying the flap pedicle was also dissected free. The flaps were divided into four groups, each consisting of 12 rats. Group 1 (Nonishemic control); Group 2 (Control) - no perfusion washout; Group 3 (Saline) - postischemic washout with normal saline solution; Group 4 (HAES) - postischemic washout with hydroxyethyl starch 10% (HAES) solution. The flaps were subjected to 11 hours of warm ischemia. Thirty minutes prior to the completion of the ischemic period, the flaps were perfused with normal saline solution in group 3 and with HAES in group 4. The percentage of flap survival was assessed on postoperative day 7. Statistical analysis was performed using the Student's t-test. Flap survival rates for Group 4 (HAES) were significantly greater than Group 2 (Control nonperfusion washout) and Group 3 (saline solution) (p<0.001). This is the first study to investigate the effect of HAES on skin flap survival based on the results, HAES solution may be useful in clinical practice.en_US
dc.identifier.citationAkın, S. ve Özcan, M. (1998). "Postischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flaps". European Journal of Plastic Surgery, 21(5), 238-242.en_US
dc.identifier.endpage242tr_TR
dc.identifier.issn0930-343X
dc.identifier.issue5tr_TR
dc.identifier.scopus2-s2.0-0031822050tr_TR
dc.identifier.startpage238tr_TR
dc.identifier.urihttps://doi.org/10.1007/s002380050081
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs002380050081
dc.identifier.urihttp://hdl.handle.net/11452/23023
dc.identifier.volume21tr_TR
dc.identifier.wos000074674100008tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.journalEuropean Journal of Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurgeryen_US
dc.subjectHAES solutionen_US
dc.subjectPostischemic washouten_US
dc.subjectSkin flap survivalen_US
dc.subjectNo-reflow phenomenonen_US
dc.subjectSuperoxide-dismutaseen_US
dc.subjectImproved survivalen_US
dc.subjectTissue-injuryen_US
dc.subjectFree-radicalsen_US
dc.subjectPerfusionen_US
dc.subjectInfusionen_US
dc.subjectUrokinaseen_US
dc.subjectIloprosten_US
dc.subjectIschemiaen_US
dc.subjectSalvageen_US
dc.subject.emtreeHetastarchen_US
dc.subject.emtreeSodium chlorideen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeInferior epigastric arteryen_US
dc.subject.emtreeIschemiaen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePedicled skin flapen_US
dc.subject.emtreePerfusionen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeSkin flapen_US
dc.subject.emtreeSkin flap survivalen_US
dc.subject.emtreeStatistical analysisen_US
dc.subject.emtreeSurvival rateen_US
dc.subject.emtreeTissue perfusionen_US
dc.subject.scopusFree Tissue Graft; Breast Reconstruction; Flaps (Control Surfaces)en_US
dc.subject.wosSurgeryen_US
dc.titlePostischemic flap washout with hydroxyethyl starch (HAES) and its beneficial effect on the no-reflow phenomenon in rat skin island flapsen_US
dc.typeArticle

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