Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis

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dc.contributor.authorCeylan, Esma
dc.contributor.authorKarkucak, Mutlu
dc.contributor.authorÇoban, Hikmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.date.accessioned2023-01-11T12:33:18Z
dc.date.available2023-01-11T12:33:18Z
dc.date.issued2016-11-18
dc.description.abstractObjective: MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among which mannose-binding lectin and tumor necrosis factor-alpha call attention. The objective of this study is to compare the frequency of TNF-alpha and MBL gene polymorphisms between patients diagnosed with tuberculosis and healthy volunteers in Turkey, and determine the association between tuberculosis and TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms. Material and methods: The study included 69 patients who were diagnosed with tuberculosis and 70 control subjects. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha (G308A) gene and MBL2 gene codon 54 polymorphisms. For statistical analysis, the significance level was determined as p < 0.05. Results: A comparison between patient and control groups in TNF-alpha (G308A) gene and MBL2 gene codon 54 polymorphisms showed no statistically significant difference (p > 0.05). However, a comparison of mean body mass index (BMI) and smoking status showed a statistically significant difference between the tuberculosis and control groups (p = 0.01 and p = 0.009, respectively). Conclusion: Our results suggest that the MBL2 gene Codon 54 and TNF-alpha gene G308A polymorphisms are not associated with an increased risk for development of tuberculosis in our patients. Further studies are required including more cases of tuberculosis patients and other potentially relevant gene polymorphisms.en_US
dc.identifier.citationCeylan, E. vd. (2017). ''Evaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosis''. Journal of Infection and Public Health, 10(6), 774-777.en_US
dc.identifier.endpage777tr_TR
dc.identifier.issn1876-0341
dc.identifier.issue6tr_TR
dc.identifier.pubmed28189510tr_TR
dc.identifier.scopus2-s2.0-85011903723tr_TR
dc.identifier.startpage774tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jiph.2016.11.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1876034117300151
dc.identifier.uri1876-035X
dc.identifier.urihttp://hdl.handle.net/11452/30402
dc.identifier.volume10tr_TR
dc.identifier.wos000414231900016tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Infection and Public Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPublic, environmental & occupational healthen_US
dc.subjectInfectious diseasesen_US
dc.subjectGene polymorphismen_US
dc.subjectMannose-binding lectinen_US
dc.subjectTuberculosisen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.subjectMannose-binding lectinen_US
dc.subjectConfers protectionen_US
dc.subjectHepatitis-Ben_US
dc.subjectAssociationen_US
dc.subjectSusceptibilityen_US
dc.subjectChildrenen_US
dc.subjectIl-10en_US
dc.subjectInterleukin-10en_US
dc.subjectMetaanalysisen_US
dc.subjectMeningitisen_US
dc.subject.emtreeMannose binding lectin 2en_US
dc.subject.emtreeTumor necrosis factoren_US
dc.subject.emtreeMannose binding lectinen_US
dc.subject.emtreeMBL2 protein, humanen_US
dc.subject.emtreeTumor necrosis factoren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeCodonen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease predispositionen_US
dc.subject.emtreeDNA isolationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeStatistical analysisen_US
dc.subject.emtreeTuberculosisen_US
dc.subject.emtreeGenetic association studyen_US
dc.subject.emtreeGenetic predispositionen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGenotyping techniqueen_US
dc.subject.emtreeImmunologyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSingle nucleotide polymorphismen_US
dc.subject.emtreeTuberculosisen_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic association studiesen_US
dc.subject.meshGenetic predisposition to diseaseen_US
dc.subject.meshGenotyping techniquesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMannose-binding lectinen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshPolymorphism, restriction fragment lengthen_US
dc.subject.meshPolymorphism, single nucleotideen_US
dc.subject.meshTuberculosisen_US
dc.subject.meshTumor necrosis factor-alphaen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusMannose-Binding Lectins; Ficolin; Collectinsen_US
dc.subject.wosPublic, environmental & occupational healthen_US
dc.subject.wosInfectious diseasesen_US
dc.titleEvaluation of TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms in Turkish patients with tuberculosisen_US
dc.typeArticle
dc.wos.quartileQ3 (Infectious diseases)en_US
dc.wos.quartileQ2 (Public, environmental & occupational Health)en_US

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