Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus

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dc.contributor.buuauthorGüleç, Süyen Güldal
dc.contributor.buuauthorNoyan, Behzat
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0863-1547tr_TR
dc.contributor.researcheridC-5730-2015tr_TR
dc.contributor.scopusid6506333172tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.date.accessioned2021-09-07T07:56:21Z
dc.date.available2021-09-07T07:56:21Z
dc.date.issued2000
dc.description.abstractThe effects of various doses of L-arginine, a nitric oxide substrate, on lithium-pilocarpine-induced seizures were studied in rats. Rats were implanted with chronic, stainless steel screw electrodes epidurally for electrocortical recordings. A control group received 3 mEq/kg LiCl (i.p.) and 24 h later 45 mg/kg pilocarpine HCl (i.p.). Two different experimental procedures were followed: (1) L-arginine was applied in doses of 100 mg/kg, 300 mg/kg or 500 mg/kg (i.p.), 30 min before pilocarpine injection; (2) 100 mg/kg, 500 mg/kg or 1000 mg/kg (i.p.) L-arginine was injected either 5 min or 30 min after the onset of status epilepticus (SE). L-arginine (300 mg/kg) injected 30 min before pilocarpine significantly reduced the percentage of SE, but did not change the latency to SE or 24-hour survival. These parameters were not significantly affected by the 100 mg/kg or 500 mg/kg dose of L-arginine. On the other hand, no dose of L-arginine that was applied after SE had begun, had any significant influence on the seizures. We concluded that L-arginine may prevent seizure activity in some but not all doses, and does not have any effect on the ongoing seizure activity.en_US
dc.identifier.citationNoyan, B. ve Güleç, S. G. (2000). "Effects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticus". Physiological Research, 49(3), 379-385.en_US
dc.identifier.endpage385tr_TR
dc.identifier.issn0862-8408
dc.identifier.issue3tr_TR
dc.identifier.pubmed11043926tr_TR
dc.identifier.scopus2-s2.0-0033840174tr_TR
dc.identifier.startpage379tr_TR
dc.identifier.urihttps://europepmc.org/article/med/11043926
dc.identifier.urihttp://hdl.handle.net/11452/21721
dc.identifier.volume49tr_TR
dc.identifier.wos000088843100012tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherAcad Sciences Czech Republic Institute of Physiologyen_US
dc.relation.journalPhysiological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhysiologyen_US
dc.subjectNitric oxideen_US
dc.subjectL-arginineen_US
dc.subjectStatus epilepticusen_US
dc.subjectRaten_US
dc.subjectNitric-oxide synthesisen_US
dc.subjectHuman temporal-lobeen_US
dc.subjectInduced seizuresen_US
dc.subjectBrain-damageen_US
dc.subjectRatsen_US
dc.subjectEpilepsyen_US
dc.subjectModelen_US
dc.subjectMechanismsen_US
dc.subjectAciden_US
dc.subjectMiceen_US
dc.subject.scopusArginine Vasopressin; Learning and Memory; Spatial Learningen_US
dc.subject.wosPhysiologyen_US
dc.titleEffects of L-arginine on prevention and treatment of lithium-pilocarpine-induced status epilepticusen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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