Cytokine signal suppressor (SOCS) 1-1478 CA/del gene polymorphism in Turkish patients with polycystic ovary syndrome

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dc.contributor.authorGül, Cuma Bülent
dc.contributor.buuauthorGül, Özen Öz
dc.contributor.buuauthorCander, Soner
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorOral, Barbaros
dc.contributor.buuauthorErsoy, Canan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7625-9148tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.contributor.researcheridAAI-1005-2021tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.contributor.scopusid26040787100tr_TR
dc.contributor.scopusid25027068600tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.date.accessioned2023-03-29T13:11:18Z
dc.date.available2023-03-29T13:11:18Z
dc.date.issued2017-10-03
dc.description.abstractEighty-four subjects, premenopausal female patients (n=42, mean (SD) age: 26.4 (4.2) years) diagnosed with polycystic ovary syndrome (PCOS) and age-matched healthy volunteers (n=42, mean (SD) age: 27.6(3.4) years), were included in this study. Data on physical examination, anthropometric measurements and blood biochemistry analysis were recorded for each subject along with analysis for SOCS1-1478 CA/del polymorphism by polymerase chain reaction-restriction fragment length polymorphism. The relation of SOCS1-1478 CA/del polymorphism to PCOS status and insulin resistance was analysed via logistic regression analysis. Mean (SD) levels for BMI (28.5(6.5) vs.22.5 (4.9) kg/m(2), p<.001), HOMA-IR (3.1(1.8) vs.1.5 (1.0), p<.001), LDL-cholesterol (115.9(32.7) vs.100.7 (27.3)mg/dL, p=.03) and triglyceride (113.8(64.9) vs.83.3(36.3)mg/dL, p=.017) were significantly higher in patients. Groups were similar in terms of SOCS1-1478 CA/del polymorphism. No significant relation of this polymorphism was noted to PCOS and HOMA-IR. Our findings revealed no difference between groups in terms of the rate of SOCS1-1478 CA/del polymorphism, and no significant relation of this polymorphism to insulin resistance and PCOS status. IMPACT STATEMENT Polycystic ovary syndrome (PCOS), the most common cause of anovulation and the most commonly encountered form of female endocrine disease. SOCS proteins have been suggested to play a fundamental role in the negative feedback regulation of the JAK-STAT pathway, which is the major signalling pathway involved in a wide range of physiologic and pathologic processes, including inflammatory diseases, malignancies and immune disorders. Pathways involving the induction of suppression of SOCS proteins were also shown likely to be involved in mediating cytokine-induced insulin resistance. The present study was designed to determine the frequency of SOCS1-1478 CA/del gene polymorphism in patients with PCOS in relation to healthy controls and insulin resistance. Our findings revealed significantly higher rates of insulin resistance, obesity and dyslipidaemia in Turkish patients with PCOS compared with age-matched healthy controls, while no difference between study groups in terms of the rate of SOCS1-1478 CA/del polymorphism along with no significant relation of SOCS1-1478 CA/del polymorphism to insulin resistance and PCOS status. Future larger scale studies with the application of standardised diagnostic methods and criteria, and of state-of-the-art modern techniques including genomics, proteomics and pharmacogenetics would provide better understanding of the association between PCOS and genomic variants.en_US
dc.identifier.citationGül, Ö. Ö. vd. (2017). ''Cytokine signal suppressor (SOCS) 1-1478 CA/del gene polymorphism in Turkish patients with polycystic ovary syndrome''. Journal of Obstetrics and Gynaecology, 37(7), 896-901.en_US
dc.identifier.endpage901tr_TR
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7tr_TR
dc.identifier.pubmed28569589tr_TR
dc.identifier.scopus2-s2.0-85020197942tr_TR
dc.identifier.startpage896tr_TR
dc.identifier.urihttps://doi.org/10.1080/01443615.2017.1309011
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01443615.2017.1309011
dc.identifier.urihttp://hdl.handle.net/11452/31884
dc.identifier.volume37tr_TR
dc.identifier.wos000411307000012tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObstetrics & gynecologyen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectCytokine signallingen_US
dc.subjectSOCS1 polymorphismen_US
dc.subjectInsulin resistanceen_US
dc.subjectWomenen_US
dc.subjectPrevalenceen_US
dc.subjectExpressionen_US
dc.subjectVariantsen_US
dc.subjectProteinsen_US
dc.subjectGlucoseen_US
dc.subjectObesityen_US
dc.subjectHealthen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAndrostenedioneen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeC peptideen_US
dc.subject.emtreeCholesterolen_US
dc.subject.emtreeCreatinineen_US
dc.subject.emtreeEstradiolen_US
dc.subject.emtreeFollitropinen_US
dc.subject.emtreeHemoglobin A1cen_US
dc.subject.emtreeHigh density lipoprotein cholesterolen_US
dc.subject.emtreeInsulinen_US
dc.subject.emtreeLow density lipoprotein cholesterolen_US
dc.subject.emtreeLuteinizing hormoneen_US
dc.subject.emtreePrasterone sulfateen_US
dc.subject.emtreeProgesteroneen_US
dc.subject.emtreeProlactinen_US
dc.subject.emtreeSuppressor of cytokine signaling 1en_US
dc.subject.emtreeTestosteroneen_US
dc.subject.emtreeThyrotropinen_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeUreaen_US
dc.subject.emtreeUric aciden_US
dc.subject.emtreeLow density lipoprotein cholesterolen_US
dc.subject.emtreeSOCS1 proteinen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeSuppressor of cytokine signaling 1en_US
dc.subject.emtreeTriacylglycerolen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeAmenorrheaen_US
dc.subject.emtreeAndrostenedione blood levelen_US
dc.subject.emtreeAnthropometric parametersen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspartate aminotransferase blood levelen_US
dc.subject.emtreeBlood biochemistryen_US
dc.subject.emtreeBody faten_US
dc.subject.emtreeBody heighten_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeBody weighten_US
dc.subject.emtreeCholesterol blood levelen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCreatinine blood levelen_US
dc.subject.emtreeDiastolic blood pressureen_US
dc.subject.emtreeDNA polymorphismen_US
dc.subject.emtreeDyslipidemiaen_US
dc.subject.emtreeEstradiol blood levelen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFollitropin blood levelen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeHeterozygoteen_US
dc.subject.emtreeHip circumferenceen_US
dc.subject.emtreeHomozygoteen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeInsulin blood levelen_US
dc.subject.emtreeInsulin resistanceen_US
dc.subject.emtreeLuteinizing hormone blood levelen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeObesityen_US
dc.subject.emtreeOligomenorrheaen_US
dc.subject.emtreeOvary polycystic diseaseen_US
dc.subject.emtreePhysical examinationen_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreePremenopauseen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProgesterone blood levelen_US
dc.subject.emtreeProlactin blood levelen_US
dc.subject.emtreePulse rateen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSignal transductionen_US
dc.subject.emtreeSmokingen_US
dc.subject.emtreeSystolic blood pressureen_US
dc.subject.emtreeTestosterone blood levelen_US
dc.subject.emtreeThyrotropin blood levelen_US
dc.subject.emtreeTriacylglycerol blood levelen_US
dc.subject.emtreeTurk (people)en_US
dc.subject.emtreeUrea blood levelen_US
dc.subject.emtreeUric acid blood levelen_US
dc.subject.emtreeWaist circumferenceen_US
dc.subject.emtreeWaist hip ratioen_US
dc.subject.emtreeWaist to height ratioen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeOvary polycystic diseaseen_US
dc.subject.emtreeStatistical modelen_US
dc.subject.meshAdulten_US
dc.subject.meshBody mass indexen_US
dc.subject.meshCase-control studieen_US
dc.subject.meshCholesterolen_US
dc.subject.meshLDLen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene frequencyen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin resistanceen_US
dc.subject.meshLogistic modelsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPolycystic ovary syndromeen_US
dc.subject.meshPolymerase chain reactionen_US
dc.subject.meshPolymorphismen_US
dc.subject.meshGeneticen_US
dc.subject.meshPremenopauseen_US
dc.subject.meshSuppressor of cytokine signaling 1 proteinen_US
dc.subject.meshTriglyceridesen_US
dc.subject.meshTurkeyen_US
dc.subject.scopusResistin; Non Insulin Dependent Diabetes Mellitus; Human RETN Proteinen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleCytokine signal suppressor (SOCS) 1-1478 CA/del gene polymorphism in Turkish patients with polycystic ovary syndromeen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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