Intrathecal morphine in anesthesia for cesarean delivery: Dose-response relationship for combinations of low-dose intrathecal morphine and spinal bupivacaine

Simple item page
dc.contributor.buuauthorGirgin, Nermin Kelebek
dc.contributor.buuauthorGurbet, Alp
dc.contributor.buuauthorTürker, Gürkan
dc.contributor.buuauthorAksu, Hale
dc.contributor.buuauthorGülhan, Nevra
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3019-581Xtr_TR
dc.contributor.orcid0000-0002-6503-8232tr_TR
dc.contributor.researcheridAAI-6642-2021tr_TR
dc.contributor.researcheridA-7994-2018tr_TR
dc.contributor.researcheridAAH-7250-2019tr_TR
dc.contributor.researcheridS-2847-2016tr_TR
dc.contributor.scopusid55663009300tr_TR
dc.contributor.scopusid7003400116tr_TR
dc.contributor.scopusid16432662600tr_TR
dc.contributor.scopusid7003400116tr_TR
dc.contributor.scopusid6504394933tr_TR
dc.date.accessioned2021-11-29T07:42:37Z
dc.date.available2021-11-29T07:42:37Z
dc.date.issued2008-05
dc.description.abstractStudy objective: To evaluate the quality of analgesia and the severity of side effects of intrathecal morphine administered for a dose range of 0.0 to 0.4 mg for postcesarean analgesia with low-dose bupivacaine. Design: Double-blind, randomized study. Setting: University hospital. Patients: 100 ASA physical status I and II term parturients undergoing cesarean delivery with spinal anesthesia in the operating room. Interventions: Patients were randomized to one of 5 groups to receive 0.0, 0.1, 0.2, 0.3, or 0.4 mg intrathecal morphine in addition to low-dose (7.5 mg) heavy bupivacaine. Each patient received intravenous (IV) patient-controlled analgesia (PCA) with morphine after the operation. Measurements: 24-hour IV PCA morphine use and visual analog scores for pain were recorded. The severity score (4-point scale) of nausea, vomiting, and pruritus were assessed intraoperatively and at 4-hour intervals during the first 24 hours postoperatively. Main results: PCA morphine use was higher in the control group (0.0 mg) than in groups receiving 0.1, 0.2,03, or 0.4 mg intrathecal morphine. There was no difference in IV PCA morphine use between the 0.1 and 0.4-mg groups, despite a 4-fold increase in intrathecal morphine dose. There was no difference between groups in nausea and vomiting, but pruritus increased in direct proportion to the dose of intrathecal morphine (linear regression, P = 0.0001). Conclusions: The dose of 0.1 mg intrathecal morphine produces analgesia comparable with doses as high as 0.4 mg, with significantly less pruritus when combined with low-dose bupivacaine.tr_TR
dc.identifier.citationGirgin, N. K. vd. (2008). ''Intrathecal morphine in anesthesia for cesarean delivery: Dose-response relationship for combinations of low-dose intrathecal morphine and spinal bupivacaine''. Journal of Clinical Anesthesia, 20(3), 180-185.tr_TR
dc.identifier.endpage185tr_TR
dc.identifier.issn1873-4529
dc.identifier.issn0952-8180
dc.identifier.issue3tr_TR
dc.identifier.pubmed18502360tr_TR
dc.identifier.scopus2-s2.0-43849103004tr_TR
dc.identifier.startpage180tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2007.07.010
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0952818008000500
dc.identifier.urihttp://hdl.handle.net/11452/22847
dc.identifier.volume20tr_TR
dc.identifier.wos000256730800005tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherElseviertr_TR
dc.relation.journalJournal of Clinical Anesthesiatr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectAnesthesiologytr_TR
dc.subjectAnalgesiatr_TR
dc.subjectBupivacainetr_TR
dc.subjectLow-dosetr_TR
dc.subjectCesarean deliverytr_TR
dc.subjectMorphinetr_TR
dc.subjectIntrathecaltr_TR
dc.subjectSectiontr_TR
dc.subjectAnalgesiatr_TR
dc.subjectPaintr_TR
dc.subjectSufentaniltr_TR
dc.subjectEfficacytr_TR
dc.subjectPlacebotr_TR
dc.subjectOpioidstr_TR
dc.subjectRelieftr_TR
dc.subject.emtreeBupivacainetr_TR
dc.subject.emtreeMorphinetr_TR
dc.subject.emtreeAdulttr_TR
dc.subject.emtreeArticletr_TR
dc.subject.emtreeCesarean sectiontr_TR
dc.subject.emtreeClinical trialtr_TR
dc.subject.emtreeControlled clinical trialtr_TR
dc.subject.emtreeControlled studytr_TR
dc.subject.emtreeDose responsetr_TR
dc.subject.emtreeDouble blind proceduretr_TR
dc.subject.emtreeFemaletr_TR
dc.subject.emtreeHumantr_TR
dc.subject.emtreeLow drug dosetr_TR
dc.subject.emtreeMajor clinical studytr_TR
dc.subject.emtreeNauseatr_TR
dc.subject.emtreePaintr_TR
dc.subject.emtreePatienttr_TR
dc.subject.emtreeControlled analgesiatr_TR
dc.subject.emtreepriority journaltr_TR
dc.subject.emtreePruritustr_TR
dc.subject.emtreeRandomized controlled trialtr_TR
dc.subject.emtreeVisual analog scaletr_TR
dc.subject.emtreeVomitingtr_TR
dc.subject.meshAdulttr_TR
dc.subject.meshAnalgesiatr_TR
dc.subject.meshPatient-controlledtr_TR
dc.subject.meshAnalgesics, opioidtr_TR
dc.subject.meshAnesthesia, obstetricaltr_TR
dc.subject.meshAnesthesia, spinaltr_TR
dc.subject.meshAnesthetics, localtr_TR
dc.subject.meshBupivacainetr_TR
dc.subject.meshCesarean sectiontr_TR
dc.subject.meshCross-over studiestr_TR
dc.subject.meshDose-response relationship, drugtr_TR
dc.subject.meshDouble-blind methodtr_TR
dc.subject.meshFemaletr_TR
dc.subject.meshHumanstr_TR
dc.subject.meshInfusions, intravenoustr_TR
dc.subject.meshInjections, spinaltr_TR
dc.subject.meshPain measurementtr_TR
dc.subject.meshPain, postoperativetr_TR
dc.subject.meshPostoperative nausea and vomitingtr_TR
dc.subject.meshMorphinetr_TR
dc.subject.meshPregnancytr_TR
dc.subject.meshPruritustr_TR
dc.subject.scopusCesarean Section; Morphine Sulfate; Bupivacainetr_TR
dc.subject.wosAnesthesiologytr_TR
dc.titleIntrathecal morphine in anesthesia for cesarean delivery: Dose-response relationship for combinations of low-dose intrathecal morphine and spinal bupivacainetr_TR
dc.typeArticle
dc.wos.quartileQ3tr_TR

Files

License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Web of Science