Pneumonia after kidney transplant: Incidence, risk factors, and mortality

Basit Görünüm
dc.contributor.authorDizdar, Oğuzhan Sıtkı
dc.contributor.buuauthorErsoy, Alparslan
dc.contributor.buuauthorAkalın, Halis
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-0710-0923tr_TR
dc.contributor.researcheridAAH-5054-2021tr_TR
dc.contributor.researcheridAAU-8952-2020tr_TR
dc.contributor.scopusid35612977100tr_TR
dc.contributor.scopusid57207553671tr_TR
dc.date.accessioned2022-09-01T10:43:59Z
dc.date.available2022-09-01T10:43:59Z
dc.date.issued2014-06
dc.description.abstractObjectives: Pneumonia is an important cause of morbidity and mortality in recipients of solid-organ transplant. We aimed to determine risk factors for development of pneumonia and associated deaths in kidney transplant recipients. Materials and Methods: A retrospective review of medical records was performed for all kidney transplant recipients from December 1988, to April 2011. The diagnosis of community-acquired pneumonia was made from symptoms, clinical findings, and chest radiography. The diagnosis of nosocomial pneumonia was made according to published criteria. Laboratory and serologic tests, radiographic findings, cultures of respiratory specimens, and tissue biopsies were reviewed. Results: In 406 kidney transplant recipients, there were 82 patients (20%) who had 111 episodes of pneumonia, including 49 nosocomial episodes of pneumonia (44%). Bacterial infections were the most common cause (34 episodes [31%]). In multivariate analysis, significant risk factors associated with pneumonia episodes were older age, hypertension, cardiac disease, history of acute graft rejection, and not using everolimus/mycophenolate mofetil/prednisolone protocol. There were 28 episodes that resulted in death (25%), including 20 nosocomial episodes (71%). In multivariate analysis, significant risk factors associated with death from pneumonia episodes were antibiotic use in the previous 3 months, high C-reactive protein, and low albumin. Cutoff values for increased risk of death from pneumonia included C-reactive protein > 10 mg/dL and procalcitonin > 8.8 ng/mL. Conclusions: Recipients of kidney transplant may be at risk for pneumonia and associated death. Nosocomial pulmonary infections may be associated with marked morbidity and mortality in kidney transplant recipients.en_US
dc.identifier.citationDizdar, O. S. vd. (2014). "Pneumonia after kidney transplant: Incidence, risk factors, and mortality". Experimental and Clinical Transplantation, 12(3), 205-211.tr_TR
dc.identifier.endpage211tr_TR
dc.identifier.issn1304-0855
dc.identifier.issue3tr_TR
dc.identifier.pubmed24907720tr_TR
dc.identifier.scopus2-s2.0-84901915171tr_TR
dc.identifier.startpage205tr_TR
dc.identifier.urihttps://doi.org/10.6002/ect.2013.0093
dc.identifier.urihttp://ectrx.org/forms/ectrxcontentshow.php?doi_id=10.6002/ect.2013.0093
dc.identifier.urihttp://hdl.handle.net/11452/28422
dc.identifier.volume12tr_TR
dc.identifier.wos000337655800006tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherBaşkent Üniversitesitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal failureen_US
dc.subjectNephrologyen_US
dc.subjectLungen_US
dc.subjectInfectionen_US
dc.subjectCommunity-acquired pneumoniaen_US
dc.subjectPulmonary infectionsen_US
dc.subjectRecipientsen_US
dc.subjectValidationen_US
dc.subjectBacterialen_US
dc.subjectFailureen_US
dc.subjectTransplantationen_US
dc.subject.emtreeAcicloviren_US
dc.subject.emtreeAlbuminen_US
dc.subject.emtreeAzathioprineen_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeCephalosporinen_US
dc.subject.emtreeCotrimoxazoleen_US
dc.subject.emtreeCyclosporinen_US
dc.subject.emtreeEverolimusen_US
dc.subject.emtreeInterleukin 2 receptor antibodyen_US
dc.subject.emtreeIsoniaziden_US
dc.subject.emtreeMethylprednisoloneen_US
dc.subject.emtreeMycophenolic acid 2 morpholinoethyl esteren_US
dc.subject.emtreePrednisoloneen_US
dc.subject.emtreeRapamycinen_US
dc.subject.emtreeTacrolimusen_US
dc.subject.emtreeThymocyte antibodyen_US
dc.subject.emtreeValgancicloviren_US
dc.subject.emtreeAcute graft rejectionen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeAntibody titeren_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspergillus fumigatusen_US
dc.subject.emtreeChronic graft rejectionen_US
dc.subject.emtreeClinical featureen_US
dc.subject.emtreeClinical protocolen_US
dc.subject.emtreeCommunity acquired pneumoniaen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDelayed graft functionen_US
dc.subject.emtreeDiastolic blood pressureen_US
dc.subject.emtreeDisease severityen_US
dc.subject.emtreeDrug useen_US
dc.subject.emtreeDrug withdrawalen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFiberoptic bronchoscopyen_US
dc.subject.emtreeHaemophilus influenzaeen_US
dc.subject.emtreeHeart diseaseen_US
dc.subject.emtreeHospital infectionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeHypertensionen_US
dc.subject.emtreeImmunosuppressive treatmenten_US
dc.subject.emtreeIncidenceen_US
dc.subject.emtreeKidney transplantationen_US
dc.subject.emtreeLength of stayen_US
dc.subject.emtreeLoading drug doseen_US
dc.subject.emtreeLung lavageen_US
dc.subject.emtreeLung mycosisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMedical recorden_US
dc.subject.emtreeMorbidityen_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreePneumocystis pneumoniaen_US
dc.subject.emtreePseudomonas aeruginosaen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.emtreeSingle drug doseen_US
dc.subject.emtreeStenotrophomonas maltophiliaen_US
dc.subject.emtreeSystolic blood pressureen_US
dc.subject.emtreeThorax radiographyen_US
dc.subject.emtreeChi square distributionen_US
dc.subject.emtreeCommunity-acquired infectionsen_US
dc.subject.emtreeComorbidityen_US
dc.subject.emtreeCross infectionen_US
dc.subject.emtreeEpidemiologyen_US
dc.subject.emtreeGraft rejectiontr_TR
dc.subject.emtreeKaplan Meier methoden_US
dc.subject.emtreeKidney transplantationen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMortalityen_US
dc.subject.emtreeMultivariate analysisen_US
dc.subject.emtreePneumoniaen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeRisken_US
dc.subject.emtreeStatistical modelen_US
dc.subject.emtreeTimeen_US
dc.subject.emtreeTurkeyen_US
dc.subject.emtreeYoung adulten_US
dc.subject.meshAdulten_US
dc.subject.meshAge factorsen_US
dc.subject.meshChi-square distributionen_US
dc.subject.meshCommunity-acquired infectionsen_US
dc.subject.meshComorbidityen_US
dc.subject.meshCross infectionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft rejectionen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshKaplan-Meier estimateen_US
dc.subject.meshKidney transplantationen_US
dc.subject.meshLogistic modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMultivariate analysisen_US
dc.subject.meshOdds ratioen_US
dc.subject.meshPneumoniaen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshTime factorsen_US
dc.subject.meshTurkeyen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusTransplant Recipients; Urinary Tract Infections; Kidney Transplantationen_US
dc.subject.wosTransplantationen_US
dc.titlePneumonia after kidney transplant: Incidence, risk factors, and mortalityen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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