Expression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survival

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dc.contributor.authorÇelik, Nilüfer
dc.contributor.authorBilgin, Tevfik
dc.contributor.buuauthorÖzuysal, Sema
dc.contributor.buuauthorEvrensel, Türkkan
dc.contributor.buuauthorÖzgür, Tümay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9732-5340tr_TR
dc.contributor.researcheridAAJ-1027-2021tr_TR
dc.contributor.researcheridAAA-1530-2020tr_TR
dc.contributor.scopusid56616314600tr_TR
dc.contributor.scopusid54584171000tr_TR
dc.contributor.scopusid54584171000tr_TR
dc.date.accessioned2021-12-23T07:53:47Z
dc.date.available2021-12-23T07:53:47Z
dc.date.issued2009
dc.description.abstractObjective: To evaluate the expression of cyclooxygenase (COX)-2 in ovarian serous carcinomas (OSC) and its correlation with microvessel density (MVD), nm23 expression, clinicopathologic prognostic factors and survival. Methods: Specimens from 44 patients with OSC were evaluated by immunohistochemistry for COX-2 and nm23 expression. Tumor MVD was assessed with CD34 immunostaining. The survival data of the patients were found from data files. Results: 40 specimens (90.1%) showed positive COX-2 staining. Patients with high COX-2-expressed tumors had shorter overall survival, but it was not statistically significant. No correlation was found between COX-2 expression and clinicopathologic variables. There was no significant correlation between COX-2 and nm23 expression or MVD. Conclusions: COX-2 is frequently expressed in OSC. Although we could not confirm the prognostic significance of Cox-2 expression in the present cohort of OSC patients, the p value for overall Survival was just slightly greater than alpha, and this result can be referred as almost significant. We considered that the limited number of cases in Our study might affect the statistical analysis of our results. Further studies involving a larger number of patients are needed to clarify the prognostic significance of COX-2 expression in ovarian carcinomas.en_US
dc.identifier.citationÖzuysal, S. vd. (2009). "Expression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survival". European Journal of Gynaecological Oncology, 30(6), 640-645.en_US
dc.identifier.endpage645tr_TR
dc.identifier.issn0392-2936
dc.identifier.issue6tr_TR
dc.identifier.pubmed20099494tr_TR
dc.identifier.scopus2-s2.0-70949090063tr_TR
dc.identifier.startpage640tr_TR
dc.identifier.urihttp://hdl.handle.net/11452/23483
dc.identifier.volume30tr_TR
dc.identifier.wos000271614400008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherImr Pressen_US
dc.relation.bapT-2006/15tr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectCD34en_US
dc.subjectCOX-2en_US
dc.subjectCyclooxygenase-2en_US
dc.subjectImmunohistochemistryen_US
dc.subjectnm23en_US
dc.subjectOvarian serous carcinomaen_US
dc.subjectPrognosisen_US
dc.subjectIntestinal epithelial-cellsen_US
dc.subjectMetastasis-related nm23-h1en_US
dc.subjectColon-cancer cellsen_US
dc.subjectPrognostic-significanceen_US
dc.subjectTumor angiogenesisen_US
dc.subjectBreast-carcinomaen_US
dc.subjectMolecular markersen_US
dc.subjectGene-expressionen_US
dc.subjectGrowthen_US
dc.subjectAdenocarcinomasen_US
dc.subjectOncologyen_US
dc.subjectObstetrics & gynecologyen_US
dc.subject.emtreeCyclooxygenase 2en_US
dc.subject.emtreeNucleoside diphosphate kinase NM23en_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeden_US
dc.subject.emtreeAngiogenesisen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCancer survivalen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeOvary carcinomaen_US
dc.subject.emtreePrognosisen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshCystadenoma, serousen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaplan-meiers estimateen_US
dc.subject.meshMicrovesselsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshNeovascularization, pathologicen_US
dc.subject.meshNM23 nucleoside diphosphate kinasesen_US
dc.subject.meshOvarian neoplasmsen_US
dc.subject.meshSurvival analysisen_US
dc.subject.scopusCyclooxygenase 2; Celecoxib; Prostaglandin Synthaseen_US
dc.subject.wosOncologyen_US
dc.subject.wosObstetrics & gynecologyen_US
dc.titleExpression of cyclooxygenase-2 in ovarian serous carcinoma: Correlation with angiogenesis, nm23 expression and survivalen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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