Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions
dc.contributor.buuauthor | Özgüç, Halil | |
dc.contributor.buuauthor | Tokyay, Rifat | |
dc.contributor.buuauthor | Kahveci, Nevzat | |
dc.contributor.buuauthor | Serdar, Zehra | |
dc.contributor.buuauthor | Sürmen Gür, Esma | |
dc.contributor.buuauthor | Korfalı, Ender | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0001-7377-9682 | tr_TR |
dc.contributor.orcid | 0000-0003-0841-8201 | tr_TR |
dc.contributor.researcherid | AAG-7070-2021 | tr_TR |
dc.contributor.researcherid | AAG-7327-2021 | tr_TR |
dc.contributor.scopusid | 6603867989 | tr_TR |
dc.contributor.scopusid | 7003296847 | tr_TR |
dc.contributor.scopusid | 6602597846 | tr_TR |
dc.contributor.scopusid | 57222002284 | tr_TR |
dc.contributor.scopusid | 7801407302 | tr_TR |
dc.contributor.scopusid | 7004641343 | tr_TR |
dc.date.accessioned | 2023-11-23T06:36:04Z | |
dc.date.available | 2023-11-23T06:36:04Z | |
dc.date.issued | 2003-04 | |
dc.description.abstract | The sensitivity of liver to warm ischemia has always been a concern for surgeons. To monitor the ischemia and/or reperfusion injury after the Pringle maneuver (occlusion of porta hepatis) in livers subjected to hemorrhage, blood pressure, blood pH, base deficit (BE), serum alanine aminotransferase (ALT), serum and liver malondialdehyde (MDA), and liver glutathione (GSH) levels were measured. MDA is a by-product of oxidant induced lipid peroxidation, and GSH is an endogenous antioxidant. The effect of lactated Ringer's (LR) resuscitation with or without the addition of 2-oxothiazolidine-4-carboxylate (OTC), a cysteine prodrug (enhancing glutathione production) on liver injury, if any, were investigated. Rats in the sham group (n = 8) and five other groups (n = 8) underwent femoral artery and vein catheterization and laparotomy. The hemorrhage group was bled 30% of their blood volume and the ischemia group underwent occlusion of the porta hepatis 30 minutes. The hemorrhage-ischemia (HI), LR, and OTC groups underwent both hemorrhage and occlusion. The LR and OTC groups, 30 minutes after hemorrhage, received either LR resuscitation (equivalent to three times the shed blood) or LR resuscitation plus IV OTC (100 mg/kg before clamping and 100 mg/kg after declamping). Porta hepatis occlusion in the presence of hypovolemia (HI group) caused an increase in serum ALT, plasma MDA, liver NIDA, and base deficit and a decrease in blood pH levels. LR resuscitation lowered only MDA (plasma and liver) and base deficit but did not reduce ALT and increase blood pH. Although liver GSH did not change, OTC kept all parameters at control levels. OTC prevents the deleterious effects of total hepatic inflow occlusion under hypovolemic conditions, but this does not occur through enhancement liver glutathione production. OTC may protect the liver by accelerating hepatic glutathione turnover, but further studies are needed to explain its mechanism of action. | en_US |
dc.identifier.citation | Özgüç, H. vd. (2003). “Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions”. World Journal of Surgery, 27(4), 448-454. | en_US |
dc.identifier.endpage | 454 | tr_TR |
dc.identifier.issn | 0364-2313 | |
dc.identifier.issue | 4 | tr_TR |
dc.identifier.pubmed | 12658491 | tr_TR |
dc.identifier.scopus | 2-s2.0-0042744783 | tr_TR |
dc.identifier.startpage | 448 | tr_TR |
dc.identifier.uri | https://doi.org/10.1007/s00268-002-6551-x | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s00268-002-6551-x | |
dc.identifier.uri | http://hdl.handle.net/11452/34987 | |
dc.identifier.volume | 27 | tr_TR |
dc.identifier.wos | 000182421900015 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | World Journal of Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Surgery | en_US |
dc.subject | Ischemia-reperfusion injury | en_US |
dc.subject | Hemorrhagic-shock | en_US |
dc.subject | N-acetylcysteine | en_US |
dc.subject | Rat-liver | en_US |
dc.subject | Lipid peroxides | en_US |
dc.subject | Free-radicals | en_US |
dc.subject | Glutathione | en_US |
dc.subject | Resuscitation | en_US |
dc.subject | Dysfunction | en_US |
dc.subject | L-2-oxothiazolidine-4-carboxylate | en_US |
dc.subject.emtree | 2 oxo 4 thiazolidinecarboxylic acid | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | Glutathione | en_US |
dc.subject.emtree | Liver protective agent | en_US |
dc.subject.emtree | Malonaldehyde | en_US |
dc.subject.emtree | Ringer lactate solution | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bleeding | en_US |
dc.subject.emtree | Blood ph | en_US |
dc.subject.emtree | Blood pressure | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Drug mechanism | en_US |
dc.subject.emtree | Femoral artery | en_US |
dc.subject.emtree | Hypovolemia | en_US |
dc.subject.emtree | Ischemia | en_US |
dc.subject.emtree | Laparotomy | en_US |
dc.subject.emtree | Lipid peroxidation | en_US |
dc.subject.emtree | Liver hilus | en_US |
dc.subject.emtree | Liver injury | en_US |
dc.subject.emtree | Liver protection | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Reperfusion injury | en_US |
dc.subject.emtree | Treatment outcome | en_US |
dc.subject.emtree | Vein catheterization | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Constriction | en_US |
dc.subject.mesh | Hepatic artery | en_US |
dc.subject.mesh | Hypovolemia | en_US |
dc.subject.mesh | Liver | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Models, animal | en_US |
dc.subject.mesh | Portal vein | en_US |
dc.subject.mesh | Pyrrolidonecarboxylic acid | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Reperfusion injury | en_US |
dc.subject.mesh | Thiazoles | en_US |
dc.subject.mesh | Thiazolidines | en_US |
dc.subject.scopus | Carboxylic Acids; Acetaminophen; Glutathione GSH | en_US |
dc.subject.wos | Surgery | en_US |
dc.title | Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions | en_US |
dc.type | Article | |
dc.wos.quartile | Q1 | en_US |
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