Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions

dc.contributor.buuauthorÖzgüç, Halil
dc.contributor.buuauthorTokyay, Rifat
dc.contributor.buuauthorKahveci, Nevzat
dc.contributor.buuauthorSerdar, Zehra
dc.contributor.buuauthorSürmen Gür, Esma
dc.contributor.buuauthorKorfalı, Ender
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Beyin ve Sinir Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7377-9682tr_TR
dc.contributor.orcid0000-0003-0841-8201tr_TR
dc.contributor.researcheridAAG-7070-2021tr_TR
dc.contributor.researcheridAAG-7327-2021tr_TR
dc.contributor.scopusid6603867989tr_TR
dc.contributor.scopusid7003296847tr_TR
dc.contributor.scopusid6602597846tr_TR
dc.contributor.scopusid57222002284tr_TR
dc.contributor.scopusid7801407302tr_TR
dc.contributor.scopusid7004641343tr_TR
dc.date.accessioned2023-11-23T06:36:04Z
dc.date.available2023-11-23T06:36:04Z
dc.date.issued2003-04
dc.description.abstractThe sensitivity of liver to warm ischemia has always been a concern for surgeons. To monitor the ischemia and/or reperfusion injury after the Pringle maneuver (occlusion of porta hepatis) in livers subjected to hemorrhage, blood pressure, blood pH, base deficit (BE), serum alanine aminotransferase (ALT), serum and liver malondialdehyde (MDA), and liver glutathione (GSH) levels were measured. MDA is a by-product of oxidant induced lipid peroxidation, and GSH is an endogenous antioxidant. The effect of lactated Ringer's (LR) resuscitation with or without the addition of 2-oxothiazolidine-4-carboxylate (OTC), a cysteine prodrug (enhancing glutathione production) on liver injury, if any, were investigated. Rats in the sham group (n = 8) and five other groups (n = 8) underwent femoral artery and vein catheterization and laparotomy. The hemorrhage group was bled 30% of their blood volume and the ischemia group underwent occlusion of the porta hepatis 30 minutes. The hemorrhage-ischemia (HI), LR, and OTC groups underwent both hemorrhage and occlusion. The LR and OTC groups, 30 minutes after hemorrhage, received either LR resuscitation (equivalent to three times the shed blood) or LR resuscitation plus IV OTC (100 mg/kg before clamping and 100 mg/kg after declamping). Porta hepatis occlusion in the presence of hypovolemia (HI group) caused an increase in serum ALT, plasma MDA, liver NIDA, and base deficit and a decrease in blood pH levels. LR resuscitation lowered only MDA (plasma and liver) and base deficit but did not reduce ALT and increase blood pH. Although liver GSH did not change, OTC kept all parameters at control levels. OTC prevents the deleterious effects of total hepatic inflow occlusion under hypovolemic conditions, but this does not occur through enhancement liver glutathione production. OTC may protect the liver by accelerating hepatic glutathione turnover, but further studies are needed to explain its mechanism of action.en_US
dc.identifier.citationÖzgüç, H. vd. (2003). “Oxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditions”. World Journal of Surgery, 27(4), 448-454.en_US
dc.identifier.endpage454tr_TR
dc.identifier.issn0364-2313
dc.identifier.issue4tr_TR
dc.identifier.pubmed12658491tr_TR
dc.identifier.scopus2-s2.0-0042744783tr_TR
dc.identifier.startpage448tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00268-002-6551-x
dc.identifier.urihttps://link.springer.com/article/10.1007/s00268-002-6551-x
dc.identifier.urihttp://hdl.handle.net/11452/34987
dc.identifier.volume27tr_TR
dc.identifier.wos000182421900015tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalWorld Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSurgeryen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectHemorrhagic-shocken_US
dc.subjectN-acetylcysteineen_US
dc.subjectRat-liveren_US
dc.subjectLipid peroxidesen_US
dc.subjectFree-radicalsen_US
dc.subjectGlutathioneen_US
dc.subjectResuscitationen_US
dc.subjectDysfunctionen_US
dc.subjectL-2-oxothiazolidine-4-carboxylateen_US
dc.subject.emtree2 oxo 4 thiazolidinecarboxylic aciden_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeGlutathioneen_US
dc.subject.emtreeLiver protective agenten_US
dc.subject.emtreeMalonaldehydeen_US
dc.subject.emtreeRinger lactate solutionen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBleedingen_US
dc.subject.emtreeBlood phen_US
dc.subject.emtreeBlood pressureen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug mechanismen_US
dc.subject.emtreeFemoral arteryen_US
dc.subject.emtreeHypovolemiaen_US
dc.subject.emtreeIschemiaen_US
dc.subject.emtreeLaparotomyen_US
dc.subject.emtreeLipid peroxidationen_US
dc.subject.emtreeLiver hilusen_US
dc.subject.emtreeLiver injuryen_US
dc.subject.emtreeLiver protectionen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeReperfusion injuryen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeVein catheterizationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshConstrictionen_US
dc.subject.meshHepatic arteryen_US
dc.subject.meshHypovolemiaen_US
dc.subject.meshLiveren_US
dc.subject.meshMaleen_US
dc.subject.meshModels, animalen_US
dc.subject.meshPortal veinen_US
dc.subject.meshPyrrolidonecarboxylic aciden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReperfusion injuryen_US
dc.subject.meshThiazolesen_US
dc.subject.meshThiazolidinesen_US
dc.subject.scopusCarboxylic Acids; Acetaminophen; Glutathione GSHen_US
dc.subject.wosSurgeryen_US
dc.titleOxothiazolidine carboxylate provides protection against hepatocellular injury seen after porta hepatis occlusion (pringle maneuver) under hypovolemic conditionsen_US
dc.typeArticle
dc.wos.quartileQ1en_US

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