Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive protein

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dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.buuauthorHızlı, Zafer Banu
dc.contributor.buuauthorEröz, Esma
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.tr_TR
dc.contributor.scopusid35741320500tr_TR
dc.contributor.scopusid16306790300tr_TR
dc.contributor.scopusid22950749100tr_TR
dc.date.accessioned2021-12-20T08:27:36Z
dc.date.available2021-12-20T08:27:36Z
dc.date.issued2008
dc.description.abstractBackground: The main objectives of our study were to determine whether resistin was present in human breast milk and to assess resistin status in breast milk and serum in breastfeeding women for up to 180 days post-partum. Methods: Blood and breast milk samples were collected from 160 breastfeeding women enrolled on 1-3, 4-14, 15-30, 31-90 or 91-180 post-partum days. Blood samples were collected from 48 breast-fed infants at 8-24 days after birth. Milk and serum resistin levels were measured by ELISA. Results: Serum and breast milk resistin concentrations were highest (5800 +/- 1100 and 1710 +/- 68 pg/mL, respectively) at 1-3 post-partum days and decreased to 1645 +/- 210 and 1130 +/- 115 pg/mL, 1600 +/- 105 and 710 +/- 25 pg/mL, 1980 +/- 155 and 595 +/- 20 pg/mL and to 2060 +/- 300 and 670 +/- 18 pg/mL at 4-14, 15-30, 31-90 and 91-180 post-partum days, respectively. Serum resistin concentrations were correlated with those of milk (r=0.822, p < 0.001). Both milk and serum resistin concentrations were correlated positively with maternal serum estradiol, progesterone, prolactin, thyroxine, triiodothyronine, cortisol, leptin and C-reactive protein concentrations. Serum resistin concentration in breast-fed infants (4915 +/- 340 pg/mL) was higher than that observed in their consumed breast milk (1745 +/- 70 pg/mL, p < 0.001) or in serum of their breastfeeding mothers (3760 +/- 360 pg/mL, p < 0.05). Conclusions: Resistin is present in human breast milk and its concentration in breast milk decreases with time during lactation. Its concentrations in breast milk and serum are correlated with circulating levels of various reproductive and metabolic hormones and with those of the general inflammatory marker, C-reactive protein.en_US
dc.identifier.citationİlçöl, Y. Ö. vd (2008). ''Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of c-reactive protein''. Clinical Chemistry and Laboratory Medicine, 46(1), 118-124.en_US
dc.identifier.endpage124tr_TR
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue1tr_TR
dc.identifier.pubmed18020968tr_TR
dc.identifier.scopus2-s2.0-38349041883tr_TR
dc.identifier.startpage118tr_TR
dc.identifier.urihttps://doi.org/10.1515/CCLM.2008.019
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/CCLM.2008.019/html
dc.identifier.urihttp://hdl.handle.net/11452/23396
dc.identifier.volume46tr_TR
dc.identifier.wos000252851000018tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWalter de Gruyteren_US
dc.relation.bap2002/34tr_TR
dc.relation.journalClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast milk resistinen_US
dc.subjectLactationen_US
dc.subjectSerum cortisolen_US
dc.subjectSerum insulinen_US
dc.subjectSerum resistinen_US
dc.subjectSerum thyroxineen_US
dc.subjectAdipose-tissueen_US
dc.subjectFed infantsen_US
dc.subjectProinflammatory cytokinesen_US
dc.subjectBiochemical-propertiesen_US
dc.subjectInsulin-resistanceen_US
dc.subjectGene-expressionen_US
dc.subjectAdiponectinen_US
dc.subjectAdiponectinen_US
dc.subjectLactationen_US
dc.subjectMedical laboratory technologyen_US
dc.subject.emtreeC reactive proteinen_US
dc.subject.emtreeEstradiolen_US
dc.subject.emtreeHydrocortisoneen_US
dc.subject.emtreeLeptinen_US
dc.subject.emtreeLiothyronineen_US
dc.subject.emtreeProgesteroneen_US
dc.subject.emtreeProlactinen_US
dc.subject.emtreeResistinen_US
dc.subject.emtreeThyroxineen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood samplingen_US
dc.subject.emtreeBreast feedingen_US
dc.subject.emtreeBreast milken_US
dc.subject.emtreeColostrumen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHormone blood levelen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLactationen_US
dc.subject.emtreeLongitudinal studyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProtein blood levelen_US
dc.subject.emtreeProtein expressionen_US
dc.subject.emtreePuerperiumen_US
dc.subject.emtreeRegression analysisen_US
dc.subject.meshBreast feedingen_US
dc.subject.meshC-reactive proteinen_US
dc.subject.meshEstradiolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHormonesen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisoneen_US
dc.subject.meshInfanten_US
dc.subject.meshInsulinen_US
dc.subject.meshLactationen_US
dc.subject.meshLeptinen_US
dc.subject.meshMilk, humanen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProgesteroneen_US
dc.subject.meshProlactinen_US
dc.subject.meshResistinen_US
dc.subject.meshThyroxineen_US
dc.subject.meshTime factorsen_US
dc.subject.scopusHuman Milk; Leptin; Adiponectinen_US
dc.subject.wosMedical laboratory technologyen_US
dc.titleResistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive proteinen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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