Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients

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dc.contributor.authorErsoy, Fettah Fevzi
dc.contributor.authorPassadakis, Stauros Ploumis
dc.contributor.authorTam, Paul
dc.contributor.authorMemmos, Evaggelos Dimitros
dc.contributor.authorKatopodis, Pericles Konstantinos
dc.contributor.authorÇetin Özener, Çetin Özener
dc.contributor.authorFehmi Akçiçek, Fehmi Akçiçek
dc.contributor.authorÇamsarı, Taner
dc.contributor.authorAteş, Kenan
dc.contributor.authorStathakis, Panagiotis Charalampos
dc.contributor.authorArınsoy, Turgay
dc.contributor.authorKarayaylalı, İbrahim
dc.contributor.authorWu, George
dc.contributor.authorBozfakıoğlu, Semra
dc.contributor.authorAkpolat, Tekin
dc.contributor.authorUtaş, Cengiz
dc.contributor.authorDombros, Athanasios Nicholas
dc.contributor.authorVlachojannis, John George
dc.contributor.authorAtaman, Rezzan
dc.contributor.authorYardımsever, Mehmet
dc.contributor.authorKarayalçın, Binnur
dc.contributor.authorGültekin, Meral
dc.contributor.authorYılmaz, Mehmet Emin
dc.contributor.authorDimitriades, Chrysostomos Athanasios
dc.contributor.authorTsakiris, John Dimitrios
dc.contributor.buuauthorYavuz, Mahmut
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.tr_TR
dc.contributor.scopusid7006244754
dc.date.accessioned2021-08-31T05:48:38Z
dc.date.available2021-08-31T05:48:38Z
dc.date.issued2006
dc.description.abstractThe aim of this study was to assess the clinical and laboratory correlations of bone mineral density (BMD) measurements among a large population of patients on chronic peritoneal dialysis (PD). This cross-sectional, multicenter study was carried out in 292 PD patients with a mean age of 56 +/- 16 years and mean duration of PD 3.1 +/- 2.1 years. Altogether, 129 female and 163 male patients from 24 centers in Canada, Greece, and Turkey were included in the study. BMD findings, obtained by dual-energy X-ray absorptiometry (DEXA) and some other major clinical and laboratory indices of bone mineral deposition as well as uremic osteodystrophy were investigated. In the 292 patients included in the study, the mean lumbar spine T-score was -1.04 +/- 1.68, the lumbar spine Z-score was -0.31 +/- 1.68, the femoral neck T-score was -1.38 +/- 1.39, and the femoral neck Z score was -0.66 +/- 1.23. According to the WHO criteria based on lumbar spine T-scores, 19.2% of 292 patients were osteoporotic, 36.3% had osteopenia, and 44.4% had lumbar spine T-scores within the normal range. In the femoral neck area, the prevalence of osteoporosis was slightly higher (26%). The prevalence of osteoporosis was 23.3% in female patients and 16.6% in male patients with no statistically significant difference between the sexes. Agreements of lumbar spine and femoral neck T-scores for the diagnosis of osteoporosis were 66.7% and 27.3% and 83.3% for osteopenia and normal BMD values, respectively. Among the clinical and laboratory parameters we investigated in this study, the body mass index (BMI) (P < 0.001), daily urine output, and urea clearance time x dialysis time/volume (Kt/V) (P < 0.05) were statistically significantly positive and Ca x PO4 had a negative correlation (P < 0.05) with the lumbar spine T scores. Femoral neck T scores were also positively correlated with BMI, daily urine output, and KT/V; and they were negatively correlated with age. Intact parathyroid hormone levels did not correlate with any of the BMD parameters. Femoral neck Z scores were correlated with BMI (P < 0.001), and ionized calcium (P < 0.05) positively and negatively with age, total alkaline phosphatase (P < 0.05), and Ca x P (P < 0.01). The overall prevalence of fractures since the initiation of PD was 10%. Our results indicated that, considering their DEXA-based BMD values, 55% of chronic PD patients have subnormal bone mass-19% within the osteoporotic range and 36% within the osteopenic range. Our findings also indicate that low body weight is the most important risk factor for osteoporosis in chronic PD patients. An insufficient dialysis dose (expressed as KT/V) and older age may also be important risk factors for osteoporosis of PD patients.en_US
dc.identifier.citationErsoy, F. F. vd. (2006). ''Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients''. Journal of Bone and Mineral Metabolism, 24(1), 79-86.en_US
dc.identifier.endpage86tr_TR
dc.identifier.issn0914-8779
dc.identifier.issn1435-5604
dc.identifier.issue1tr_TR
dc.identifier.pubmed16369903tr_TR
dc.identifier.scopus2-s2.0-29244454547tr_TR
dc.identifier.startpage79tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00774-005-0650-3
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00774-005-0650-3
dc.identifier.urihttp://hdl.handle.net/11452/21559
dc.identifier.volume24tr_TR
dc.identifier.wos000234144800015tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSprınger Japan KKen_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalJournal of Bone and Mineral Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectResearch & experimental medicineen_US
dc.subjectBody weighten_US
dc.subjectPeritoneal dialysisen_US
dc.subjectDual-energy X-ray absorptiometry (DEXA)en_US
dc.subjectBone mineral densityen_US
dc.subjectDensitometryen_US
dc.subjectFracturesen_US
dc.subjectRisk-factorsen_US
dc.subject.scopusChronic Kidney Disease-Mineral and Bone Disorder; Bone Density; Denosumaben_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosMedicine, research & experimentalen_US
dc.titleBone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patientsen_US
dc.typeArticle
dc.wos.quartileQ3 (Medicine, research & experimental)en_US
dc.wos.quartileQ4 (Endocrinology & metabolism)en_US

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