Crossed aphasia - functional brain imaging with PET or SPECT

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dc.contributor.authorKirshner, Howard S.
dc.contributor.authorWertz, Robert T.
dc.contributor.buuauthorBakar, Mustafa
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.tr_TR
dc.date.accessioned2021-07-02T13:09:36Z
dc.date.available2021-07-02T13:09:36Z
dc.date.issued1996
dc.description.abstractObjectives: To study patients with crossed aphasia (aphasia secondary to lesions in the right hemisphere in right-handed patients) with functional brain imaging using positron emission tomography (PET) or single photon emission computed tomography (SPECT); to see whether left hemisphere structures were metabolically depressed during the acute phase and, in 1 patient, during recovery; and to review the modern literature on crossed aphasia, with special reference to left hemisphere involvement. Design: Case studies of 3 patients with crossed aphasia, including language testing, computed tomographic scanning, and functional imaging with PET or SPECT. Setting: Hospital case studies. Patients: Three-right-handed patients with crossed aphasia secondary to acute infarctions in the right hemisphere and left hemiparesis. Methods: All 3 patients were studied by means of bedside language testing, computed tomographic scanning, and functional brain imaging with PET or SPECT. Patient 1 also underwent serial testing with the Boston Diagnostic Aphasia Examination and follow-up PET scanning after 2 months of recovery. Outcome Measures: Clinical examination in all 3 patients and follow-up Boston Diagnostic Aphasia Examination and PET scanning in patient 1. Results: Two patients had severe global aphasia and 1 had Broca aphasia. In all cases, computed tomographic scans failed to reveal any left hemispheric lesions. Functional imaging with PET or SPECT showed extensive hypometabolism or hypoperfusion in the right hemisphere, with initial reductions in the left hemisphere as well. In patient 1, a follow-up PET image showed only persistent hypometabolism in the right hemisphere. Conclusions: These findings suggest that abnormal dominance for at least some language functions in the right hemisphere underlies the syndrome of crossed aphasia. Diaschisis, or functional depression of the anatomically normal left hemisphere, was seen in all 3 patients during the acute phase, but not in patient 1 after recovery had begun.tr_TR
dc.identifier.citationBakar, M. vd. (1996). "Crossed aphasia - functional brain imaging with PET or SPECT". Archives of Neurology, 53(10), 1026-1032.tr_TR
dc.identifier.endpage1032tr_TR
dc.identifier.issn0003-9942
dc.identifier.issue10tr_TR
dc.identifier.pubmed8859065tr_TR
dc.identifier.scopus2-s2.0-0029836801tr_TR
dc.identifier.startpage1026tr_TR
dc.identifier.urihttps://doi.org/10.1001/archneur.1996.00550100112020
dc.identifier.urihttps://jamanetwork.com/journals/jamaneurology/article-abstract/594249
dc.identifier.urihttp://hdl.handle.net/11452/21006
dc.identifier.volume53tr_TR
dc.identifier.wosA1996VM03100014tr_TR
dc.indexed.pubmedPubmedtr_TR
dc.indexed.scopusScopustr_TR
dc.indexed.wosSCIEtr_TR
dc.language.isoentr_TR
dc.publisherAmer Medical Assoctr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalArchives of Neurologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccesstr_TR
dc.subjectNeurosciences & neurologytr_TR
dc.subjectTranshemispheric diaschisistr_TR
dc.subjectUnilateral stroketr_TR
dc.subjectLanguagetr_TR
dc.subjectLateralizationtr_TR
dc.subjectTomographytr_TR
dc.subjectAsymmetriestr_TR
dc.subjectHemispheretr_TR
dc.subjectDominancetr_TR
dc.subjectMRItr_TR
dc.subject.wosClinical neurologytr_TR
dc.titleCrossed aphasia - functional brain imaging with PET or SPECTtr_TR
dc.typeArticle

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