Arginine vasopressin does not contribute to seizures induced by intracerebroventricularly-injected pilocarpine

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dc.contributor.buuauthorGüleç, Güldal
dc.contributor.buuauthorBüyükcoşkun, Naciye İşbil
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-0863-1547tr_TR
dc.contributor.researcheridC-5730-2015tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.scopusid6602752303tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.date.accessioned2022-02-04T06:22:44Z
dc.date.available2022-02-04T06:22:44Z
dc.date.issued2005-12
dc.description.abstractArginine vasopressin (AVP) has been shown to contribute to the production Of seizures. Here, we aimed to investigate the effects of AVP on seizures induced by intracerebroventricular (i.c.v.) injection of pilocarpine. Rats were treated with 0.2-2.4 mg/5 mu l pilocarpine intracerebroventricularly, to obtain the dose-response relationship for behavioural seizures. 2.4 mg/5 mu l pilocarpine induced status epilepticus ill 111 rats and 0.2 mg/5 mu l pilocarpine did not produce any sign of seizure in any of the rats. In the second step, AVP (0.01-1000 ng/2 mu l; i.c.v.) was injected 5 min before i.c.v. injection of a low dose pilocarpine (0.4 mg/5 mu l) and rats were observed for percentage of status epilepticus, status epilepticus latency and behavioural seizure scores. None of the applied doses of AVP had any significant effect oil seizures induced by 0.4 mg/5 mu l i.c.v. pilocarpine. Subcutaneous injection of 1000 ng AVP 1 h before 0.4 mg i.c.v. pilocarpine also did not produce Significant difference with respect to the 0.4 mg pilocarpine group. Finally, pretreatment with neither an AVP V-1 receptor antagonist (25, 125, 250 ng/5 mu l; i.c.v.) nor an AVP V-2 receptor antagonist (25, 125, 250 ng/5 mu l; i.c.v.) prevented status epilepticus, induced by 2.4 mg/5 mu l i.c.v. pilocarpine. We conclude that AVP does not act as a convulsant agent in centrally-induced pilocarpine seizures.en_US
dc.identifier.citationGüleç, G. ve Büyükcoşkun, N. İ. (2005). "Arginine vasopressin does not contribute to seizures induced by intracerebroventricularly-injected pilocarpine". Neuropeptides, 39(6), 575-579.en_US
dc.identifier.endpage579tr_TR
dc.identifier.issn0143-4179
dc.identifier.issn1532-2785
dc.identifier.issue6tr_TR
dc.identifier.pubmed16246417tr_TR
dc.identifier.scopus2-s2.0-28344439802tr_TR
dc.identifier.startpage575tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.npep.2005.09.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0143417905000910
dc.identifier.urihttp://hdl.handle.net/11452/24341
dc.identifier.volume39tr_TR
dc.identifier.wos000233960100005tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.journalNeuropeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocrinology & metabolismen_US
dc.subjectNeurosciences & neurologyen_US
dc.subjectArginine vasopressinen_US
dc.subjectPilocarpineen_US
dc.subjectSeizureen_US
dc.subjectIntracerebroventricularen_US
dc.subjectRaten_US
dc.subjectCentral-nervous-systemen_US
dc.subjectSuprachiasmatic nucleusen_US
dc.subjectFebrile convulsionen_US
dc.subjectMessenger-rnaen_US
dc.subjectOxytocinen_US
dc.subjectRatsen_US
dc.subjectReceptorsen_US
dc.subjectEpilepsyen_US
dc.subjectBrainen_US
dc.subjectExpressionen_US
dc.subjectAnimaliaen_US
dc.subject.emtreeArgipressinen_US
dc.subject.emtreePilocarpineen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeEpileptic stateen_US
dc.subject.emtreeLatent perioden_US
dc.subject.emtreeLow drug doseen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSeizureen_US
dc.subject.emtreeTimeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArginine vasopressinen_US
dc.subject.meshConvulsantsen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshInjections, intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscarinic agonistsen_US
dc.subject.meshPilocarpineen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, sprague-dawleyen_US
dc.subject.meshStatus epilepticusen_US
dc.subject.scopusArginine Vasopressin; Learning and Memory; Spatial Learningen_US
dc.subject.wosEndocrinology & metabolismen_US
dc.subject.wosNeurosciencesen_US
dc.titleArginine vasopressin does not contribute to seizures induced by intracerebroventricularly-injected pilocarpineen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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