Shape analysis of the corpus callosum and cerebellum in female MS patients with different clinical phenotypes

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dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorÖzdemir, Senem Turan
dc.contributor.buuauthorTaşkapılıoğlu, Özlem
dc.contributor.buuauthorHakyemez, Bahattin
dc.contributor.buuauthorTuran, Ömer Faruk
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Noroloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-4436-3797tr_TR
dc.contributor.orcid0000-0002-3425-0740tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.researcheridX-4479-2018tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.contributor.researcheridAAA-8734-2021tr_TR
dc.contributor.researcheridAAI-2318-2021tr_TR
dc.contributor.researcheridAAK-6623-2020tr_TR
dc.contributor.scopusid24482063400tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid18038353400tr_TR
dc.contributor.scopusid6602527239tr_TR
dc.contributor.scopusid23037113500tr_TR
dc.contributor.scopusid23037226400tr_TR
dc.date.accessioned2022-05-20T10:58:20Z
dc.date.available2022-05-20T10:58:20Z
dc.date.issued2012-07
dc.description.abstractThe aim of this study was to investigate the shape differences in the corpus callosum (CC) and cerebellum of female relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients compared with healthy controls. This study was conducted using the magnetic resonance imaging scans of 15 control subjects, 26 RRMS, and 14 SPMS patients. The data obtained from the landmark coordinates were analyzed with statistical shape analysis. The landmarks that were chosen to determine the shape differences of the CC and cerebellum have been identified and used in previous studies. In addition to these landmarks, constructed landmarks were determined and used to assess regional shape differences better. The shapes of the CC and cerebellum showed statistically significant differences from the controls when compared with both the RRMS and SPMS patients. It was found that the deformation observed from controls to SPMS was greater than the deformation from controls to RRMS, both for the CC and cerebellum. In conclusion, this study revealed CC and cerebellar shape change in RRMS and SPMS, and showed that deformations both in CC and cerebellum advances with the disease progression.en_US
dc.identifier.citationSığırlı, D. vd. (2012). "Shape analysis of the corpus callosum and cerebellum in female MS patients with different clinical phenotypes". Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 295(7), 1202-1211.en_US
dc.identifier.endpage1211tr_TR
dc.identifier.issn1932-8486
dc.identifier.issn1932-8494
dc.identifier.issue7tr_TR
dc.identifier.pubmed22585536tr_TR
dc.identifier.scopus2-s2.0-84862491548tr_TR
dc.identifier.startpage1202tr_TR
dc.identifier.urihttps://doi.org/10.1002/ar.22493
dc.identifier.urihttps://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/ar.22493
dc.identifier.urihttp://hdl.handle.net/11452/26563
dc.identifier.volume295tr_TR
dc.identifier.wos000305238200015tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.journalAnatomical Record-Advances in Integrative Anatomy and Evolutionary Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnatomy & morphologyen_US
dc.subjectMultiple sclerosisen_US
dc.subjectCorpus callosumen_US
dc.subjectCerebellumen_US
dc.subjectStatistical shape analysisen_US
dc.subjectGeometric morphometricsen_US
dc.subjectMultiple-sclerosisen_US
dc.subjectMorphometric-analysisen_US
dc.subjectVolumeen_US
dc.subjectBrainen_US
dc.subjectHippocampusen_US
dc.subjectDisabilityen_US
dc.subjectSizeen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCerebellumen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCorpus callosumen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMultiple sclerosisen_US
dc.subject.emtreeNeuroanatomyen_US
dc.subject.emtreeNeuroimagingen_US
dc.subject.emtreeNuclear magnetic resonance imagingen_US
dc.subject.emtreePhenotypeen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeRetrospective studyen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshCerebellumen_US
dc.subject.meshCorpus callosumen_US
dc.subject.meshDisease progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic resonance imagingen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMultiple sclerosis, chronic progressiveen_US
dc.subject.meshMultiple sclerosis, relapsing-remittingen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshYoung adulten_US
dc.subject.scopusCorpus Callosum; Cerebrum; Isthmusesen_US
dc.subject.wosAnatomy & morphologyen_US
dc.titleShape analysis of the corpus callosum and cerebellum in female MS patients with different clinical phenotypesen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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