3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum

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dc.contributor.buuauthorBüyükuysal, R. Levent
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.buuauthorSami, Aydın
dc.contributor.buuauthorKiran, Burhan K.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.tr_TR
dc.contributor.researcheridD-5340-2015tr_TR
dc.contributor.researcheridAAH-1657-2021tr_TR
dc.date.accessioned2021-07-05T11:07:54Z
dc.date.available2021-07-05T11:07:54Z
dc.date.issued1995-04-13
dc.description.abstractWe investigated the effects of choline, 3,4-diaminopyridine and their combination on acetylcholine release from the corpus striatum of freely moving rats which were treated or not with atropine. Intraperitoneal administration of choline or intrastriatal administration of 3,4-diaminopyridine increased acetylcholine levels in striatal dialysates in a dose-dependent manner. When 3,4-diaminopyridine treatment was combined with choline, the observed effect was considerably greater than the sum of the increases produced by choline or 3,4-diaminopyridine alone. Administration of atropine (1 mu M) in the dialysing medium was also found to be effective to stimulate striatal acetylcholine levels. 3,4-Diaminopyridine did not affect acetylcholine levels under these conditions. Whereas the choline-induced increase in acetylcholine release was significantly potentiated by atropine, co-administration of 3,4-diaminopyridine with choline failed to produce a further significant increase in the presence of atropine. These results suggest that a highly effective means for increasing acetylcholine release involves two concurrent treatments that increase neuronal choline levels and inhibition of the negative feedback modulation of acetylcholine release.en_US
dc.identifier.citationBüyükuysal, R. L. vd. (1995). ''3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatum''. European Journal of Pharmacology, 281(2), 179-185.tr_TR
dc.identifier.endpage185tr_TR
dc.identifier.issn0014-2999
dc.identifier.issue2tr_TR
dc.identifier.pubmed7589205tr_TR
dc.identifier.scopus2-s2.0-0028893043tr_TR
dc.identifier.startpage179tr_TR
dc.identifier.urihttps://doi.org/10.1016/0014-2999(95)00241-C
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/001429999500241C
dc.identifier.urihttp://hdl.handle.net/11452/21061
dc.identifier.volume281tr_TR
dc.identifier.wosA1995RN82700008tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Science BVen_US
dc.relation.journalEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholineen_US
dc.subjectCholineen_US
dc.subject3,4-Diaminopyridineen_US
dc.subjectMicrodialysisen_US
dc.subject4-Aminopyridineen_US
dc.subjectSlicesen_US
dc.subjectStimulationen_US
dc.subjectHippocampusen_US
dc.subjectMembraneen_US
dc.subjectMicrodialysisen_US
dc.subjectTransmitter releaseen_US
dc.subjectPotassium channelsen_US
dc.subjectCorpus striatumen_US
dc.subjectInvivo releaseen_US
dc.subjectPharmacology & pharmacyen_US
dc.subject.wosPharmacology & pharmacyen_US
dc.title3,4-Diaminopyridine and choline increase in vivo acetylcholine release in rat striatumen_US
dc.typeArticle

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