Topical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study

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dc.contributor.authorÖzmen, Süay
dc.contributor.buuauthorÖzmen, Ömer Afşin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9698-0546tr_TR
dc.contributor.researcheridA-1452-2019tr_TR
dc.contributor.scopusid55407733900tr_TR
dc.date.accessioned2021-12-24T10:24:29Z
dc.date.available2021-12-24T10:24:29Z
dc.date.issued2011-06
dc.description.abstractObjective: To compare the topical administration of bupivacaine hydrochloride, lidocaine hydrochloride with epinephrine and saline in alleviating post tonsillectomy pain. Study design: A double-blind prospective randomized controlled clinical study. Methods: Between November 2008 and March 2009, 60 patients (32 males and 28 females) between ages of 1.5 and 15 years were recruited into the study. After informed consent was obtained from the parents, patients, admitted for tonsillectomy, were randomized into three groups using sealed envelops. Group 1 (20 patients, mean age 5.2 +/- 1.7) received topical lidocaine hydrochloride (20 mg/ml) with 0.00125% epinephrine. Group 2 (20 patients, mean age 6 +/- 3.7) received topical 0.5% bupivacaine hydrochloride and group 3 (20 patients, mean age 6.7 +/- 3.6) received topical saline. Results: The post-operative pain scores at 1 h were similar among the groups (p = 0.29). Pain scores in bupivacaine hydrochloride group were significantly lesser than the saline group at 5th, 13th, 17th and 21st hours, until the sixth day (p < 0.017). Moreover, pain scores of bupivacaine hydrochloride group were superior to lidocaine hydrochloride group starting at 17 h, until fourth day (p < 0.017). Pain scores of lidocaine hydrochloride group were lesser than saline group in the first and fifth days (p < 0.017), whereas, there was no significant difference at other times. Conclusion: Topical administration of bupivacaine hydrochloride proved to provide more efficient pain control than both saline and lidocaine without any drug related complication.en_US
dc.identifier.citationÖzmen, Ö. A. ve Özmen, S. (2011). "Topical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study". International Journal of Pediatric Otorhinolaryngology, 75(1), 77-80.en_US
dc.identifier.endpage80tr_TR
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue1tr_TR
dc.identifier.pubmed21067823tr_TR
dc.identifier.scopus2-s2.0-78650996409tr_TR
dc.identifier.startpage77tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2010.10.013
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165587610004805
dc.identifier.urihttp://hdl.handle.net/11452/23574
dc.identifier.volume75tr_TR
dc.identifier.wos000287065800016tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.relation.collaborationSanayitr_TR
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOtorhinolaryngologyen_US
dc.subjectPediatricsen_US
dc.subjectTonsillectomyen_US
dc.subjectPainen_US
dc.subjectBupivacaineen_US
dc.subjectLidocaineen_US
dc.subjectPostoperative tonsillar infiltrationen_US
dc.subjectPeritonsillar infiltrationen_US
dc.subjectPediatric tonsillectomyen_US
dc.subjectDouble-blinden_US
dc.subjectControlled trialen_US
dc.subjectRopivacaineen_US
dc.subjectAdenotonsillectomyen_US
dc.subjectAnesthesiaen_US
dc.subjectReductionen_US
dc.subjectMorbidityen_US
dc.subject.emtreeAdrenalinen_US
dc.subject.emtreeBupivacaineen_US
dc.subject.emtreeLidocaineen_US
dc.subject.emtreeAdolescenten_US
dc.subject.emtreeAirway obstructionen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBleedingen_US
dc.subject.emtreeChilden_US
dc.subject.emtreeDehydrationen_US
dc.subject.emtreeDouble blind procedureen_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFeveren_US
dc.subject.emtreeHalitosisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeOtalgiaen_US
dc.subject.emtreePain assessmenten_US
dc.subject.emtreePostoperative nauseaen_US
dc.subject.emtreePostoperative painen_US
dc.subject.emtreePostoperative vomitingen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeRandomized controlled trialen_US
dc.subject.emtreeTonsillectomyen_US
dc.subject.emtreeTrismusen_US
dc.subject.meshAdministration, topicalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnesthetics, localen_US
dc.subject.meshBupivacaineen_US
dc.subject.meshChilden_US
dc.subject.meshChild, preschoolen_US
dc.subject.meshDouble-blind methoden_US
dc.subject.meshDrug therapy, combinationen_US
dc.subject.meshEpinephrineen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-up studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshLidocaineen_US
dc.subject.meshMaleen_US
dc.subject.meshPain measurementen_US
dc.subject.meshPain, postoperativeen_US
dc.subject.meshPatient satisfactionen_US
dc.subject.meshProspective studiesen_US
dc.subject.meshRisk assessmenten_US
dc.subject.meshTonsillectomyen_US
dc.subject.scopusTonsillectomy; Palatine Tonsil; Postoperative Hemorrhageen_US
dc.subject.wosOtorhinolaryngologyen_US
dc.subject.wosPediatricsen_US
dc.titleTopical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled studyen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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