Analysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndrome

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dc.contributor.authorKarkucak, Mutlu
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorGörükmez, Orhan
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorErcan, İlker
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-9027-1132tr_TR
dc.contributor.orcid0000-0002-2382-290Xtr_TR
dc.contributor.researcheridAAG-8744-2021tr_TR
dc.contributor.researcheridAAI-3169-2021tr_TR
dc.contributor.researcheridAAH-5180-2021tr_TR
dc.contributor.scopusid8329319900tr_TR
dc.contributor.scopusid15832295800tr_TR
dc.contributor.scopusid56681045900tr_TR
dc.contributor.scopusid6602802424tr_TR
dc.contributor.scopusid6603789069tr_TR
dc.contributor.scopusid6601970351tr_TR
dc.date.accessioned2022-04-11T11:01:41Z
dc.date.available2022-04-11T11:01:41Z
dc.date.issued2012-10
dc.description.abstractObjective: Tumor necrosis factor-alpha (TNF-alpha) is an important indicator of inflammation. Recent studies have demonstrated a relationship between inflammation and obstructive sleep apnea syndrome (OSAS). The aim of this study was to investigate the association between TNF-alpha G308A and C857T gene polymorphisms and OSAS in Turkish patients. Material and Methods: Sixty-nine patients who were diagnosed with OSAS and 42 control subjects were included in the study. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect TNF-alpha G308A and C857T gene polymorphisms. The level of significance for statistical analysis was set at p<0.05. Results: The distribution of genotypes was not significantly different between subjects with a definite diagnosis of OSAS and the control group (p> 0.05). However, the mean body mass index of the OSAS group was significantly different from that of the control group (p<0.05). Conclusion: To our knowledge, this study is the first to analyze the relationship between OSAS and INF-alpha G308A and C857T gene polymorphisms in Turkish patients. Our results do not support an association between OSAS and TNF-alpha G308A and C857T gene polymorphisms.en_US
dc.identifier.citationKarkucak, M. vd. (2012). "Analysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndrome". Türkiye Klinikleri Tıp Bilimleri Dergisi, 32(5), 1368-1373.tr_TR
dc.identifier.endpage1373tr_TR
dc.identifier.issn1300-0292
dc.identifier.issue5tr_TR
dc.identifier.scopus2-s2.0-84863865498tr_TR
dc.identifier.startpage1368tr_TR
dc.identifier.urihttps://doi.org/10.5336/medsci.2012-28126
dc.identifier.urihttps://www.turkiyeklinikleri.com/article/en-analysis-of-tnf-alpha-g308a-and-c857t-gene-polymorphisms-in-turkish-patients-with-obstructive-sleep-apnea-syndrome-63032.html
dc.identifier.urihttp://hdl.handle.net/11452/25696
dc.identifier.volume32tr_TR
dc.identifier.wos000313378300023tr_TR
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherOrtadogu Yayınevitr_TR
dc.relation.collaborationSanayitr_TR
dc.relation.journalTürkiye Klinikleri Tıp Bilimleri Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGeneral & internal medicineen_US
dc.subjectPolymorphism, single nucleotideen_US
dc.subjectSleep apnea, obstructiveen_US
dc.subjectAngiotensin-converting enzymeen_US
dc.subjectCardiovascular-diseaseen_US
dc.subjectPromoter polymorphismen_US
dc.subjectAssociationen_US
dc.subjectCytokinesen_US
dc.subjectObesityen_US
dc.subjectArthritisen_US
dc.subjectAllelesen_US
dc.subjectRegionen_US
dc.subject.emtreeTumor necrosis factor alphaen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeApnea hypopnea indexen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBody massen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGeneen_US
dc.subject.emtreeGene frequencyen_US
dc.subject.emtreeGenetic associationen_US
dc.subject.emtreeGenetic polymorphismen_US
dc.subject.emtreeGenetic variabilityen_US
dc.subject.emtreeGenome analysisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMolecular weighten_US
dc.subject.emtreePolymerase chain reactionen_US
dc.subject.emtreeRestriction fragment length polymorphismen_US
dc.subject.emtreeSleep apnea syndromeen_US
dc.subject.emtreeTumor necrosis factor alpha geneen_US
dc.subject.scopusObstructive Sleep Apnea; Polysomnography; Snoringen_US
dc.subject.wosMedicine, general & internalen_US
dc.titleAnalysis of TNF-alpha G308A and C857T gene polymorphisms in Turkish patients with obstructive sleep apnea syndromeen_US
dc.title.alternativeObstrüktif uyku apne sendromu olan türk hastalarda TNF-alfa G308A ve C857T gen polimorfizmlerinin incelenmesitr_TR
dc.typeArticle

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