Effect Of tamoxifen treatment on the epidermal growth factor receptor expression ın the mouse ovarian tissue

dc.contributor.buuauthorAsmaz, Ender Deniz
dc.contributor.buuauthorZık, Berrin
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi.tr_TR
dc.date.accessioned2020-12-21T08:42:08Z
dc.date.available2020-12-21T08:42:08Z
dc.date.issued2018-07-03
dc.description.abstractThe objective of this study was to investigate the effect of Tamoxifen (TAM) treatment on epidermal growth factor receptor (EGFR) expression in the pubertal mice ovary. In this study, 80 female mice (8 week-old) were used. Animals divided four groups; non-injected (control A), injected with TAM’s vehicle solution (control B). The mice in groups TAM 0.5 and TAM 1.5 were treated with TAM at a dose 0.5 and 1.5 mg/mouse/day respectively. TAM was dissolved with 10% ethanol: 90% corn oil. Mice were given daily subcutaneously injections for 5 days. Ovarian sections were immunostained with EGFR antibody and trichrome staining for examine the general structure. We observed that follicular atresia was increased, follicular cysts were formed in stroma, and interstitial cells were increased with TAM dose treatment. In the present study, there were no significant differences in the EGFR expression in mouse ovary of all groups. EGFR expression was not determined in the granulosa cells. While strong EGFR immunoreaction was observed in the interstitial cells and oocyte cytoplasm, weak EGFR immunoreactions was observed in theca cells of follicles.en_US
dc.identifier.citationAsmaz , E. D. ve Zık, B. (2018). "Effect Of tamoxifen treatment on the epidermal growth factor receptor expression ın the mouse ovarian tissue". Uludağ Üniversitesi Veteriner Fakültesi, 37(2), 119-125.tr_TR
dc.identifier.endpage125tr_TR
dc.identifier.issn1301-3173
dc.identifier.issue2tr_TR
dc.identifier.startpage119tr_TR
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/532957
dc.identifier.urihttp://hdl.handle.net/11452/14499
dc.identifier.volume37tr_TR
dc.language.isoenen_US
dc.publisherBursa Uludağ Üniversitesitr_TR
dc.relation.journalVeteriner Hekimlikte Araştırma Dergisi / Journal of Research in Veterinary Medicinetr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.relation.tubitakTÜBİTAK-TOVAK ( 112 O 574 )tr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEGFRen_US
dc.subjectImmunohistochemistryen_US
dc.subjectOvaryen_US
dc.subjectTamoxifenen_US
dc.titleEffect Of tamoxifen treatment on the epidermal growth factor receptor expression ın the mouse ovarian tissueen_US
dc.typeArticleen_US

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