AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients
dc.contributor.author | Eminler, Ahmet Tarık | |
dc.contributor.author | Ayyıldız, Talat | |
dc.contributor.buuauthor | Irak, Kader | |
dc.contributor.buuauthor | Kıyıcı, Murat | |
dc.contributor.buuauthor | Gürel, Selim | |
dc.contributor.buuauthor | Dolar, Enver | |
dc.contributor.buuauthor | Gülten, Macit | |
dc.contributor.buuauthor | Nak, Selim G. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-3208-6211 | tr_TR |
dc.contributor.researcherid | AAG-9177-2021 | tr_TR |
dc.contributor.researcherid | AAI-4213-2021 | tr_TR |
dc.contributor.scopusid | 37080733400 | tr_TR |
dc.contributor.scopusid | 6507627491 | tr_TR |
dc.contributor.scopusid | 7003706434 | tr_TR |
dc.contributor.scopusid | 6602075084 | tr_TR |
dc.contributor.scopusid | 6603629209 | tr_TR |
dc.contributor.scopusid | 6603336505 | tr_TR |
dc.date.accessioned | 2022-06-10T12:49:30Z | |
dc.date.available | 2022-06-10T12:49:30Z | |
dc.date.issued | 2015-12 | |
dc.description.abstract | Background and aim Noninvasive tests are primarily used for staging hepatic fibrosis in patients with chronic liver disease. In clinical practice, serum aminotransferase levels, coagulation parameters, and platelet count have been used to predict whether or not a patient has cirrhosis. In addition, several studies have evaluated the accuracy of combinations (or ratios) of these measures. The present study aimed to investigate the relationship between five noninvasive models [AST/ALT ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), age-platelet index (APind), and King's score] and the degree of hepatic fibrosis as determined by biopsy in patients with chronic hepatitis B and C. Patients and methods A total of 380 patients with viral hepatitis (237 with chronic hepatitis B and 143 with chronic hepatitis C) who were seen at our clinic between January 2005 and January 2011 were retrospectively analyzed. The degree of fibrosis was determined using the Ishak score. Patients with a fibrosis score of 0-2 were considered to have low fibrosis and those with a score between 3 and 6 were considered to have high fibrosis. Five noninvasive models were compared between the groups with low and high fibrosis. Results There were statistically significant differences between the hepatitis B and C patients with high and low fibrosis with respect to APind (4.492.35 vs. 2.41 +/- 1.84; P<0.001 in hepatitis B and 4.83 +/- 2.25 vs. 2.92 +/- 1.88; P<0.001 in hepatitis C), APRI (1.00 +/- 1.17 vs. 0.47 +/- 0.39; P<0.001 in hepatitis B and 1.01 +/- 1.01 vs. 0.41 +/- 0.29; P<0.001 in hepatitis C), CDS (4.53 +/- 1.90 vs. 3.58 +/- 1.30; P<0.001 in hepatitis B and 4.71 +/- 2.03 vs. 3.42 +/- 1.49; P<0.05 in hepatitis C), and King's score (24.31 +/- 3.14 vs. 7.65 +/- 6.70; P<0.001 in hepatitis B and 24.82 +/- 2.55 vs. 8.33 +/- 7.29; P<0.001 in hepatitis C). There were no significant differences in the AAR between the hepatitis B and C patients with high and low fibrosis (0.78 +/- 0.31 vs. 0.74 +/- 0.34; P=0.082 in hepatitis B and 0.91 +/- 0.40 vs. 0.85 +/- 0.27; P=0.25 in hepatitis C). The area under the receiver-operating characteristic curve of the APind, APRI, CDS, and King's score in the hepatitis B group were 0.767, 0.710, 0.646, and 0.770, respectively; these values were 0.732, 0.763, 0.677, and 0.783, respectively, in the hepatitis C group. Conclusion In conclusion, our data suggest that four of the five noninvasive methods evaluated in this study can be used to predict advanced fibrosis in patients with hepatitis B and C. However, there was no significant relationship between the degree of hepatic fibrosis and the AAR score, indicating that AAR is not useful in estimating the fibrosis stage in hepatitis B and C patients. | en_US |
dc.identifier.citation | Eminler, A. T. vd. (2015). "AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients". European Journal of Gastroenterology and Hepatology, 27(12), 1361-1366. | en_US |
dc.identifier.endpage | 1366 | tr_TR |
dc.identifier.issn | 0954-691X | |
dc.identifier.issue | 12 | tr_TR |
dc.identifier.pubmed | 26352130 | tr_TR |
dc.identifier.scopus | 2-s2.0-84947017512 | tr_TR |
dc.identifier.startpage | 1361 | tr_TR |
dc.identifier.uri | https://doi.org/10.1097/MEG.0000000000000468 | |
dc.identifier.uri | https://journals.lww.com/eurojgh/Fulltext/2015/12000/AST_ALT_ratio_is_not_useful_in_predicting_the.1.aspx | |
dc.identifier.uri | http://hdl.handle.net/11452/27051 | |
dc.identifier.volume | 27 | tr_TR |
dc.identifier.wos | 000364330100001 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams & Wilkins | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | European Journal of Gastroenterology and Hepatology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | AST/ALT ratio | en_US |
dc.subject | Fibrosis | en_US |
dc.subject | Hepatitis B | en_US |
dc.subject | Hepatitis C | en_US |
dc.subject | C virus-infection | en_US |
dc.subject | Chronic liver-disease | en_US |
dc.subject | Blood-tests | en_US |
dc.subject | Aspartate-aminotransferase | en_US |
dc.subject | Noninvasive assessment | en_US |
dc.subject | Alanine aminotransferase | en_US |
dc.subject | Cirrhosis | en_US |
dc.subject | Index | en_US |
dc.subject | Accuracy | en_US |
dc.subject | Transaminase | en_US |
dc.subject | Gastroenterology & hepatology | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | Aspartate aminotransferase | en_US |
dc.subject.emtree | Alanine aminotransferase | en_US |
dc.subject.emtree | Aspartate aminotransferase | en_US |
dc.subject.emtree | Biological marker | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Age platelet index | en_US |
dc.subject.emtree | Alanine aminotransferase blood level | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Aspartate aminotransferase alanine aminotransferase ratio | en_US |
dc.subject.emtree | Aspartate aminotransferase blood level | en_US |
dc.subject.emtree | Aspartate aminotransferase to platelet ratio index | en_US |
dc.subject.emtree | Bonacini cirrhosis discriminant score | en_US |
dc.subject.emtree | Chronic hepatitis B | en_US |
dc.subject.emtree | Chronic hepatitis C | en_US |
dc.subject.emtree | Digestive system disease assessment | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human tissue | en_US |
dc.subject.emtree | Investigative procedures | en_US |
dc.subject.emtree | Ishak score | en_US |
dc.subject.emtree | King s score | en_US |
dc.subject.emtree | Liver biopsy | en_US |
dc.subject.emtree | Liver fibrosis | en_US |
dc.subject.emtree | Major clinical study | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Non invasive procedure | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Receiver operating characteristic | en_US |
dc.subject.emtree | Retrospective study | ten_US |
dc.subject.emtree | Scoring system | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Chronic hepatitis C | en_US |
dc.subject.emtree | Complication | en_US |
dc.subject.emtree | Enzyme assay | en_US |
dc.subject.emtree | Evaluation study | en_US |
dc.subject.emtree | Hepatitis B | en_US |
dc.subject.emtree | Liver cirrhosis | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Predictive value | en_US |
dc.subject.emtree | Procedures | en_US |
dc.subject.emtree | Sensitivity and specificity | en_US |
dc.subject.emtree | Severity of illness index | en_US |
dc.subject.emtree | Thrombocyte count | en_US |
dc.subject.emtree | Virology | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Alanine transaminase | en_US |
dc.subject.mesh | Aspartate aminotransferases | en_US |
dc.subject.mesh | Biomarkers | en_US |
dc.subject.mesh | Clinical enzyme tests | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hepatitis B, chronic | en_US |
dc.subject.mesh | Hepatitis c, chronic | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver cirrhosis | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Platelet count | en_US |
dc.subject.mesh | Predictive value of tests | en_US |
dc.subject.mesh | Retrospective studies | en_US |
dc.subject.mesh | Sensitivity and specificity | en_US |
dc.subject.mesh | Severity of illness index | en_US |
dc.subject.scopus | Elasticity Imaging Techniques; Esophagus Varices; Fibrosis | en_US |
dc.subject.wos | Gastroenterology & hepatology | en_US |
dc.title | AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients | en_US |
dc.type | Article | |
dc.wos.quartile | Q3 | en_US |
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