AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients

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dc.contributor.authorEminler, Ahmet Tarık
dc.contributor.authorAyyıldız, Talat
dc.contributor.buuauthorIrak, Kader
dc.contributor.buuauthorKıyıcı, Murat
dc.contributor.buuauthorGürel, Selim
dc.contributor.buuauthorDolar, Enver
dc.contributor.buuauthorGülten, Macit
dc.contributor.buuauthorNak, Selim G.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-3208-6211tr_TR
dc.contributor.researcheridAAG-9177-2021tr_TR
dc.contributor.researcheridAAI-4213-2021tr_TR
dc.contributor.scopusid37080733400tr_TR
dc.contributor.scopusid6507627491tr_TR
dc.contributor.scopusid7003706434tr_TR
dc.contributor.scopusid6602075084tr_TR
dc.contributor.scopusid6603629209tr_TR
dc.contributor.scopusid6603336505tr_TR
dc.date.accessioned2022-06-10T12:49:30Z
dc.date.available2022-06-10T12:49:30Z
dc.date.issued2015-12
dc.description.abstractBackground and aim Noninvasive tests are primarily used for staging hepatic fibrosis in patients with chronic liver disease. In clinical practice, serum aminotransferase levels, coagulation parameters, and platelet count have been used to predict whether or not a patient has cirrhosis. In addition, several studies have evaluated the accuracy of combinations (or ratios) of these measures. The present study aimed to investigate the relationship between five noninvasive models [AST/ALT ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), age-platelet index (APind), and King's score] and the degree of hepatic fibrosis as determined by biopsy in patients with chronic hepatitis B and C. Patients and methods A total of 380 patients with viral hepatitis (237 with chronic hepatitis B and 143 with chronic hepatitis C) who were seen at our clinic between January 2005 and January 2011 were retrospectively analyzed. The degree of fibrosis was determined using the Ishak score. Patients with a fibrosis score of 0-2 were considered to have low fibrosis and those with a score between 3 and 6 were considered to have high fibrosis. Five noninvasive models were compared between the groups with low and high fibrosis. Results There were statistically significant differences between the hepatitis B and C patients with high and low fibrosis with respect to APind (4.492.35 vs. 2.41 +/- 1.84; P<0.001 in hepatitis B and 4.83 +/- 2.25 vs. 2.92 +/- 1.88; P<0.001 in hepatitis C), APRI (1.00 +/- 1.17 vs. 0.47 +/- 0.39; P<0.001 in hepatitis B and 1.01 +/- 1.01 vs. 0.41 +/- 0.29; P<0.001 in hepatitis C), CDS (4.53 +/- 1.90 vs. 3.58 +/- 1.30; P<0.001 in hepatitis B and 4.71 +/- 2.03 vs. 3.42 +/- 1.49; P<0.05 in hepatitis C), and King's score (24.31 +/- 3.14 vs. 7.65 +/- 6.70; P<0.001 in hepatitis B and 24.82 +/- 2.55 vs. 8.33 +/- 7.29; P<0.001 in hepatitis C). There were no significant differences in the AAR between the hepatitis B and C patients with high and low fibrosis (0.78 +/- 0.31 vs. 0.74 +/- 0.34; P=0.082 in hepatitis B and 0.91 +/- 0.40 vs. 0.85 +/- 0.27; P=0.25 in hepatitis C). The area under the receiver-operating characteristic curve of the APind, APRI, CDS, and King's score in the hepatitis B group were 0.767, 0.710, 0.646, and 0.770, respectively; these values were 0.732, 0.763, 0.677, and 0.783, respectively, in the hepatitis C group. Conclusion In conclusion, our data suggest that four of the five noninvasive methods evaluated in this study can be used to predict advanced fibrosis in patients with hepatitis B and C. However, there was no significant relationship between the degree of hepatic fibrosis and the AAR score, indicating that AAR is not useful in estimating the fibrosis stage in hepatitis B and C patients.en_US
dc.identifier.citationEminler, A. T. vd. (2015). "AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients". European Journal of Gastroenterology and Hepatology, 27(12), 1361-1366.en_US
dc.identifier.endpage1366tr_TR
dc.identifier.issn0954-691X
dc.identifier.issue12tr_TR
dc.identifier.pubmed26352130tr_TR
dc.identifier.scopus2-s2.0-84947017512tr_TR
dc.identifier.startpage1361tr_TR
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000000468
dc.identifier.urihttps://journals.lww.com/eurojgh/Fulltext/2015/12000/AST_ALT_ratio_is_not_useful_in_predicting_the.1.aspx
dc.identifier.urihttp://hdl.handle.net/11452/27051
dc.identifier.volume27tr_TR
dc.identifier.wos000364330100001tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalEuropean Journal of Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAST/ALT ratioen_US
dc.subjectFibrosisen_US
dc.subjectHepatitis Ben_US
dc.subjectHepatitis Cen_US
dc.subjectC virus-infectionen_US
dc.subjectChronic liver-diseaseen_US
dc.subjectBlood-testsen_US
dc.subjectAspartate-aminotransferaseen_US
dc.subjectNoninvasive assessmenten_US
dc.subjectAlanine aminotransferaseen_US
dc.subjectCirrhosisen_US
dc.subjectIndexen_US
dc.subjectAccuracyen_US
dc.subjectTransaminaseen_US
dc.subjectGastroenterology & hepatologyen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeAlanine aminotransferaseen_US
dc.subject.emtreeAspartate aminotransferaseen_US
dc.subject.emtreeBiological markeren_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAge platelet indexen_US
dc.subject.emtreeAlanine aminotransferase blood levelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeAspartate aminotransferase alanine aminotransferase ratioen_US
dc.subject.emtreeAspartate aminotransferase blood levelen_US
dc.subject.emtreeAspartate aminotransferase to platelet ratio indexen_US
dc.subject.emtreeBonacini cirrhosis discriminant scoreen_US
dc.subject.emtreeChronic hepatitis Ben_US
dc.subject.emtreeChronic hepatitis Cen_US
dc.subject.emtreeDigestive system disease assessmenten_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman tissueen_US
dc.subject.emtreeInvestigative proceduresen_US
dc.subject.emtreeIshak scoreen_US
dc.subject.emtreeKing s scoreen_US
dc.subject.emtreeLiver biopsyen_US
dc.subject.emtreeLiver fibrosisen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNon invasive procedureen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeReceiver operating characteristicen_US
dc.subject.emtreeRetrospective studyten_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeBlooden_US
dc.subject.emtreeChronic hepatitis Cen_US
dc.subject.emtreeComplicationen_US
dc.subject.emtreeEnzyme assayen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeHepatitis Ben_US
dc.subject.emtreeLiver cirrhosisen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreePredictive valueen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeSensitivity and specificityen_US
dc.subject.emtreeSeverity of illness indexen_US
dc.subject.emtreeThrombocyte counten_US
dc.subject.emtreeVirologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAlanine transaminaseen_US
dc.subject.meshAspartate aminotransferasesen_US
dc.subject.meshBiomarkersen_US
dc.subject.meshClinical enzyme testsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B, chronicen_US
dc.subject.meshHepatitis c, chronicen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver cirrhosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPlatelet counten_US
dc.subject.meshPredictive value of testsen_US
dc.subject.meshRetrospective studiesen_US
dc.subject.meshSensitivity and specificityen_US
dc.subject.meshSeverity of illness indexen_US
dc.subject.scopusElasticity Imaging Techniques; Esophagus Varices; Fibrosisen_US
dc.subject.wosGastroenterology & hepatologyen_US
dc.titleAST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patientsen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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