Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes
dc.contributor.author | Yılmaz, Sunde Süslüer | |
dc.contributor.author | Büyükgüngör, Orhan | |
dc.contributor.buuauthor | Yılmaz, Veysel Turan | |
dc.contributor.buuauthor | Göçmen, Elif | |
dc.contributor.buuauthor | İçsel, Ceyda | |
dc.contributor.buuauthor | Cengiz, Murat | |
dc.contributor.department | Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü. | tr_TR |
dc.contributor.orcid | 0000-0002-2849-3332 | tr_TR |
dc.contributor.orcid | 0000-0002-2717-2430 | tr_TR |
dc.contributor.researcherid | AAI-3342-2021 | tr_TR |
dc.contributor.researcherid | L-7238-2018 | tr_TR |
dc.contributor.researcherid | ABE-5935-2020 | tr_TR |
dc.contributor.scopusid | 7006269202 | tr_TR |
dc.contributor.scopusid | 55992981200 | tr_TR |
dc.contributor.scopusid | 55551960400 | tr_TR |
dc.contributor.scopusid | 16635026700 | tr_TR |
dc.date.accessioned | 2022-09-09T07:11:19Z | |
dc.date.available | 2022-09-09T07:11:19Z | |
dc.date.issued | 2014-02-05 | |
dc.description.abstract | Four new silver(I) saccharinate (sac) complexes, [Ag(mu-sac)(PPh3)](2) (1), [Ag(mu-sac)(PPh2CY)](2) (2), [Ag(mu-sac)(PPhCy2)](2) (3) and [Ag(mu-sac)(PCy3)](n) (4), where PPh3 = triphenylphosphane, PPh2Cy = cyclohexyldiphenylphosphane, PPhCy2 = dicyclohexylphenylphosphane and PCy3 = tricyclohexylphosphane, have been synthesized and fully characterized by elemental analysis, IR, NMR, ESI-MS and single crystal X-ray diffraction. Fluorescence ethidium bromide displacement indicate that all complexes bind to fish sperm (FS) DNA by intercalation with binding constants (K-A) of 29.1 +/- 0.26 x 10(5) M-1 for 1, 2.54 +/- 0.12 x 10(5) M-1 for 2, 2.42 +/- 0.08 x 10(5) M-1 for 3, 0.19 +/- 0.03 x 10(5) M-1 for 4. The relative viscosities of the FS-DNA solutions increase with increasing of the complex concentration, providing strong evidence for the intercalation mode. The gel electrophoresis assay further confirms their binding with the pBR322 plasmid DNA. The MIC values of the silver(I) complexes are generally higher than those of AgNO3 and silver sulfadiazine, but 1 presents a promising activity against Salmonella typhimurium and Staphylococcus aureus. All complexes are highly cytotoxic on human lung carcinoma (A549) and human breast adenocarcinoma (MCF-7) cell lines with IC50 values ranging from 0.82 to 3.13 mu M. | en_US |
dc.identifier.citation | Yılmaz, V. T. vd. (2014). "Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes". Journal of Photochemistry and Photobiology B: Biology, 131, 31-42. | en_US |
dc.identifier.endpage | 42 | tr_TR |
dc.identifier.issn | 1011-1344 | |
dc.identifier.pubmed | 24480545 | tr_TR |
dc.identifier.scopus | 2-s2.0-84893161859 | tr_TR |
dc.identifier.startpage | 31 | tr_TR |
dc.identifier.uri | https://doi.org/10.1016/j.jphotobiol.2013.12.014 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1011134413002947 | |
dc.identifier.uri | http://hdl.handle.net/11452/28595 | |
dc.identifier.volume | 131 | tr_TR |
dc.identifier.wos | 000333790100004 | tr_TR |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.bap | UAP(F)-2011/36 | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Journal of Photochemistry and Photobiology B: Biology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Silver(I) | en_US |
dc.subject | Saccharinate | en_US |
dc.subject | Phosphine | en_US |
dc.subject | DNA binding | en_US |
dc.subject | Antibacterial activity | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | X-ray | en_US |
dc.subject | Antimicrobial activities | en_US |
dc.subject | Heterocyclic thiones | en_US |
dc.subject | Triphenylphosphine ligands | en_US |
dc.subject | Antiproliferative activity | en_US |
dc.subject | Platinum(ıı) complexes | en_US |
dc.subject | Molecular-structures | en_US |
dc.subject | Anticancer activity | en_US |
dc.subject | Ethidium-bromide | en_US |
dc.subject | Thermal analyses | en_US |
dc.subject | Biochemistry & molecular biology | en_US |
dc.subject | Biophysics | en_US |
dc.subject.emtree | Ciprofloxacin | en_US |
dc.subject.emtree | Cisplatin | en_US |
dc.subject.emtree | Gentamicin | en_US |
dc.subject.emtree | Silver derivative | en_US |
dc.subject.emtree | Sulfadiazine silver | en_US |
dc.subject.emtree | Antiinfective agent | en_US |
dc.subject.emtree | Antineoplastic agent | en_US |
dc.subject.emtree | DNA | en_US |
dc.subject.emtree | Phosphine | en_US |
dc.subject.emtree | Phosphine derivative | en_US |
dc.subject.emtree | Saccharin | en_US |
dc.subject.emtree | Silver derivative | en_US |
dc.subject.emtree | Antibacterial activity | en_US |
dc.subject.emtree | Antineoplastic activity | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bacterial strain | en_US |
dc.subject.emtree | Binding affinity | en_US |
dc.subject.emtree | Breast adenocarcinoma | en_US |
dc.subject.emtree | Carcinoma cell | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Crystal structure | en_US |
dc.subject.emtree | DNA binding | en_US |
dc.subject.emtree | Drug cytotoxicity | en_US |
dc.subject.emtree | Drug synthesis | en_US |
dc.subject.emtree | Electrospray mass spectrometry | en_US |
dc.subject.emtree | Fluorescence | en_US |
dc.subject.emtree | Fluorescence spectroscopy | en_US |
dc.subject.emtree | Gel electrophoresis | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Human cell | en_US |
dc.subject.emtree | In vitro study | en_US |
dc.subject.emtree | Lung carcinoma | en_US |
dc.subject.emtree | Minimum inhibitory concentration | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Nuclear magnetic resonance | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Salmonella typhimurium | en_US |
dc.subject.emtree | Staphylococcus aureus | en_US |
dc.subject.emtree | Viscometry | en_US |
dc.subject.emtree | X ray crystallography | en_US |
dc.subject.emtree | Chemical structure | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Drug effects | en_US |
dc.subject.emtree | Drug screening | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Microbial sensitivity test | en_US |
dc.subject.emtree | Synthesis | en_US |
dc.subject.emtree | Tumor cell line | en_US |
dc.subject.mesh | Anti-bacterial agents | en_US |
dc.subject.mesh | Antineoplastic agents | en_US |
dc.subject.mesh | Cell line, tumor | en_US |
dc.subject.mesh | Chemistry techniques, synthetic | en_US |
dc.subject.mesh | Crystallography, X-ray | en_US |
dc.subject.mesh | DNA | en_US |
dc.subject.mesh | Drug screening assays, antitumor | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Microbial sensitivity tests | en_US |
dc.subject.mesh | Molecular structure | en_US |
dc.subject.mesh | Phosphines | en_US |
dc.subject.mesh | Saccharin | en_US |
dc.subject.mesh | Silver compounds | en_US |
dc.subject.scopus | Complex; Diphenyl Ethers; Silver | en_US |
dc.subject.wos | Biochemistry & molecular biology | en_US |
dc.subject.wos | Biophysics | en_US |
dc.title | Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes | en_US |
dc.type | Article | |
dc.wos.quartile | Q2 | en_US |
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