Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes

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dc.contributor.authorYılmaz, Sunde Süslüer
dc.contributor.authorBüyükgüngör, Orhan
dc.contributor.buuauthorYılmaz, Veysel Turan
dc.contributor.buuauthorGöçmen, Elif
dc.contributor.buuauthorİçsel, Ceyda
dc.contributor.buuauthorCengiz, Murat
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Öncesi Bilimler Bölümü.tr_TR
dc.contributor.orcid0000-0002-2849-3332tr_TR
dc.contributor.orcid0000-0002-2717-2430tr_TR
dc.contributor.researcheridAAI-3342-2021tr_TR
dc.contributor.researcheridL-7238-2018tr_TR
dc.contributor.researcheridABE-5935-2020tr_TR
dc.contributor.scopusid7006269202tr_TR
dc.contributor.scopusid55992981200tr_TR
dc.contributor.scopusid55551960400tr_TR
dc.contributor.scopusid16635026700tr_TR
dc.date.accessioned2022-09-09T07:11:19Z
dc.date.available2022-09-09T07:11:19Z
dc.date.issued2014-02-05
dc.description.abstractFour new silver(I) saccharinate (sac) complexes, [Ag(mu-sac)(PPh3)](2) (1), [Ag(mu-sac)(PPh2CY)](2) (2), [Ag(mu-sac)(PPhCy2)](2) (3) and [Ag(mu-sac)(PCy3)](n) (4), where PPh3 = triphenylphosphane, PPh2Cy = cyclohexyldiphenylphosphane, PPhCy2 = dicyclohexylphenylphosphane and PCy3 = tricyclohexylphosphane, have been synthesized and fully characterized by elemental analysis, IR, NMR, ESI-MS and single crystal X-ray diffraction. Fluorescence ethidium bromide displacement indicate that all complexes bind to fish sperm (FS) DNA by intercalation with binding constants (K-A) of 29.1 +/- 0.26 x 10(5) M-1 for 1, 2.54 +/- 0.12 x 10(5) M-1 for 2, 2.42 +/- 0.08 x 10(5) M-1 for 3, 0.19 +/- 0.03 x 10(5) M-1 for 4. The relative viscosities of the FS-DNA solutions increase with increasing of the complex concentration, providing strong evidence for the intercalation mode. The gel electrophoresis assay further confirms their binding with the pBR322 plasmid DNA. The MIC values of the silver(I) complexes are generally higher than those of AgNO3 and silver sulfadiazine, but 1 presents a promising activity against Salmonella typhimurium and Staphylococcus aureus. All complexes are highly cytotoxic on human lung carcinoma (A549) and human breast adenocarcinoma (MCF-7) cell lines with IC50 values ranging from 0.82 to 3.13 mu M.en_US
dc.identifier.citationYılmaz, V. T. vd. (2014). "Synthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanes". Journal of Photochemistry and Photobiology B: Biology, 131, 31-42.en_US
dc.identifier.endpage42tr_TR
dc.identifier.issn1011-1344
dc.identifier.pubmed24480545tr_TR
dc.identifier.scopus2-s2.0-84893161859tr_TR
dc.identifier.startpage31tr_TR
dc.identifier.urihttps://doi.org/10.1016/j.jphotobiol.2013.12.014
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1011134413002947
dc.identifier.urihttp://hdl.handle.net/11452/28595
dc.identifier.volume131tr_TR
dc.identifier.wos000333790100004tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.bapUAP(F)-2011/36tr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of Photochemistry and Photobiology B: Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilver(I)en_US
dc.subjectSaccharinateen_US
dc.subjectPhosphineen_US
dc.subjectDNA bindingen_US
dc.subjectAntibacterial activityen_US
dc.subjectCytotoxic activityen_US
dc.subjectX-rayen_US
dc.subjectAntimicrobial activitiesen_US
dc.subjectHeterocyclic thionesen_US
dc.subjectTriphenylphosphine ligandsen_US
dc.subjectAntiproliferative activityen_US
dc.subjectPlatinum(ıı) complexesen_US
dc.subjectMolecular-structuresen_US
dc.subjectAnticancer activityen_US
dc.subjectEthidium-bromideen_US
dc.subjectThermal analysesen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectBiophysicsen_US
dc.subject.emtreeCiprofloxacinen_US
dc.subject.emtreeCisplatinen_US
dc.subject.emtreeGentamicinen_US
dc.subject.emtreeSilver derivativeen_US
dc.subject.emtreeSulfadiazine silveren_US
dc.subject.emtreeAntiinfective agenten_US
dc.subject.emtreeAntineoplastic agenten_US
dc.subject.emtreeDNAen_US
dc.subject.emtreePhosphineen_US
dc.subject.emtreePhosphine derivativeen_US
dc.subject.emtreeSaccharinen_US
dc.subject.emtreeSilver derivativeen_US
dc.subject.emtreeAntibacterial activityen_US
dc.subject.emtreeAntineoplastic activityen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBacterial strainen_US
dc.subject.emtreeBinding affinityen_US
dc.subject.emtreeBreast adenocarcinomaen_US
dc.subject.emtreeCarcinoma cellen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeCrystal structureen_US
dc.subject.emtreeDNA bindingen_US
dc.subject.emtreeDrug cytotoxicityen_US
dc.subject.emtreeDrug synthesisen_US
dc.subject.emtreeElectrospray mass spectrometryen_US
dc.subject.emtreeFluorescenceen_US
dc.subject.emtreeFluorescence spectroscopyen_US
dc.subject.emtreeGel electrophoresisen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeLung carcinomaen_US
dc.subject.emtreeMinimum inhibitory concentrationen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeNuclear magnetic resonanceen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeSalmonella typhimuriumen_US
dc.subject.emtreeStaphylococcus aureusen_US
dc.subject.emtreeViscometryen_US
dc.subject.emtreeX ray crystallographyen_US
dc.subject.emtreeChemical structureen_US
dc.subject.emtreeChemistryen_US
dc.subject.emtreeDrug effectsen_US
dc.subject.emtreeDrug screeningen_US
dc.subject.emtreeMetabolismen_US
dc.subject.emtreeMicrobial sensitivity testen_US
dc.subject.emtreeSynthesisen_US
dc.subject.emtreeTumor cell lineen_US
dc.subject.meshAnti-bacterial agentsen_US
dc.subject.meshAntineoplastic agentsen_US
dc.subject.meshCell line, tumoren_US
dc.subject.meshChemistry techniques, syntheticen_US
dc.subject.meshCrystallography, X-rayen_US
dc.subject.meshDNAen_US
dc.subject.meshDrug screening assays, antitumoren_US
dc.subject.meshHumansen_US
dc.subject.meshMicrobial sensitivity testsen_US
dc.subject.meshMolecular structureen_US
dc.subject.meshPhosphinesen_US
dc.subject.meshSaccharinen_US
dc.subject.meshSilver compoundsen_US
dc.subject.scopusComplex; Diphenyl Ethers; Silveren_US
dc.subject.wosBiochemistry & molecular biologyen_US
dc.subject.wosBiophysicsen_US
dc.titleSynthesis, crystal structures, in vitro DNA binding, antibacterial and cytotoxic activities of new di- and polynuclear silver(I) saccharinate complexes with tertiary monophosphanesen_US
dc.typeArticle
dc.wos.quartileQ2en_US

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