Assessment of molecular events in squamous and non-squamous cell lung carcinoma

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dc.contributor.authorSchulten, Hans-Jürgen
dc.contributor.authorDemir, Adalet
dc.contributor.authorFrank, Derk
dc.contributor.authorDanner, Bernd
dc.contributor.authorKahler, Elke
dc.contributor.authorGunawan, Bastian
dc.contributor.authorÜrer, Nur
dc.contributor.authorFuezesi, Laszlo
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorGebitekin, Cengiz
dc.contributor.buuauthorÖztürk, Hülya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-7904-883Xtr_TR
dc.contributor.researcheridAAH-1420-2021tr_TR
dc.date.accessioned2021-09-13T07:04:11Z
dc.date.available2021-09-13T07:04:11Z
dc.date.issued2006
dc.description.abstractAlthough considerable knowledge exists on the tumor biology of lung cancer, there is still a need to assess molecular events for the clinical management of the disease. We studied the pattern of chromosomal imbalances in 45 non-small cell Lung carcinomas (NSCLC) by comparative genomic hybridization (CGH) and correlated the results with clinicopathological features including immunohistochemical (IHC) expression of the epidermal. growth factor receptor (EGFR). Twenty-one tumors were squamous cell carcinomas (SCC) and 24 non-squamous cell lung carcinomas (NSCC) comprising 9 adenocarcinomas (ADC), 9 large cell carcinomas (LCC), 4 sarcomatoid carcinomas and 2 adenosquamous carcinomas. The mean number of individual imbalances was 7.1 for SCC (mean gains, 3.8; mean tosses, 3.4) and 6.4 for NSCC (mean gains, 4.5; mean tosses, 1.9). Several individual imbalances correlated significantly with increasing number of imbalances, that were +1q, -3p, +3q, -5q, -8p, +8q, +7p, +12p, and +14q. Altogether, the most frequent imbalances were +3q (49%), +5p (49%), -5q (36%), +8q (29%), -8p (24%), -3p (22%), +7p (22%), +12p (22%), +14q (20%), +18p (20%), +1q (18%), and +7q (18%). Among these, +3q and +18p correlated significantly with SCC, and +5p and +14q with NSCC. Remarkably, overlapping imbalances included +3q26, +7p11 in SCC and +1q21, +3q24, +12p11, and +14q12 in NSCC. EGFR expression was higher in SCC than in NSCC and correlated with +3q in the entire series. In addition, +12p correlated significantly with disease progress with the exception of nodal involvement in NSCC as well as with disease progress, regardless of nodal involvement, in the entire series. In conclusion, the present study contributes to the molecular biological characterization of NSCLC histological subtypes and through evaluation of molecular events to the recently emergent focus on novel markers for lung cancer treatment.en_US
dc.identifier.citationYakut, T. vd. (2006). ''Assessment of molecular events in squamous and non-squamous cell lung carcinoma''. Lung Cancer, 54(3), 293-301.en_US
dc.identifier.endpage301tr_TR
dc.identifier.issn0169-5002
dc.identifier.issn1872-8332
dc.identifier.issue3tr_TR
dc.identifier.pubmed17011066tr_TR
dc.identifier.scopus2-s2.0-33750352066tr_TR
dc.identifier.startpage293tr_TR
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0169500206004302
dc.identifier.urihttps://doi.org/10.1016/j.lungcan.2006.08.011
dc.identifier.urihttp://hdl.handle.net/11452/21873
dc.identifier.volume54tr_TR
dc.identifier.wos000242424200003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherElsevier Irelanden_US
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationYurt içitr_TR
dc.relation.journalLung Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOncologyen_US
dc.subjectRespiratory systemen_US
dc.subjectEpidermal growth factor receptoren_US
dc.subjectComparative genomic hybridizationen_US
dc.subjectNon-small cell lung carcinomaen_US
dc.subjectGeneen_US
dc.subjectMutationsen_US
dc.subjectExpressionen_US
dc.subjectAdenocarcinomaen_US
dc.subjectCanceren_US
dc.subjectHigh-levelen_US
dc.subjectPrognostic valueen_US
dc.subjectChromosomal imbalancesen_US
dc.subjectGrowth-factor receptoren_US
dc.subject.scopusNon-Small Cell Lung Carcinoma; Lung Neoplasms; ErbB-1 Genesen_US
dc.subject.wosOncologyen_US
dc.subject.wosRespiratory systemen_US
dc.titleAssessment of molecular events in squamous and non-squamous cell lung carcinomaen_US
dc.typeArticle
dc.wos.quartileQ2 (Oncology)en_US
dc.wos.quartileQ1 (Respiratory system)en_US

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