Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis

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dc.contributor.buuauthorSağ, Saim
dc.contributor.buuauthorNas, Ömer Fatih
dc.contributor.buuauthorKaderli, Aysel Aydın
dc.contributor.buuauthorÖzdemir, Bülent
dc.contributor.buuauthorBaran, İbrahim
dc.contributor.buuauthorErdoğan, Cüneyt
dc.contributor.buuauthorGüllülü, Sümeyye
dc.contributor.buuauthorHakyemez, Bahattin
dc.contributor.buuauthorAydınlar, Ali
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0001-8404-8252tr_TR
dc.contributor.orcid0000-0002-3425-0740tr_TR
dc.contributor.orcid0000-0002-8974-8837tr_TR
dc.contributor.researcheridAAW-9185-2020tr_TR
dc.contributor.researcheridAAG-8561-2021tr_TR
dc.contributor.researcheridAAI-2318-2021tr_TR
dc.contributor.researcheridAAI-6632-2021tr_TR
dc.contributor.scopusid12140008100tr_TR
dc.contributor.scopusid51864050100tr_TR
dc.contributor.scopusid7801322152tr_TR
dc.contributor.scopusid7004168959tr_TR
dc.contributor.scopusid35572557400tr_TR
dc.contributor.scopusid8293835700tr_TR
dc.contributor.scopusid57204660708tr_TR
dc.contributor.scopusid6602527239tr_TR
dc.contributor.scopusid6603131517tr_TR
dc.date.accessioned2022-11-21T08:38:22Z
dc.date.available2022-11-21T08:38:22Z
dc.date.issued2016-10
dc.description.abstractThe treatment options for high risk acute pulmonary embolism (PE) patients with failed systemic thrombolytic treatment (STT) is limited. The clinical use of catheter directed thrombolysis with the EkoSonic Endovascular System (EKOS) in this population has not been evaluated before. Catheter directed thrombolysis is an effective treatment modality for high risk PE patients with failed STT. Thirteen consecutive patients with failed STT were included in the study. EKOS catheters were placed and tissue plasminogen activator (t-PA) in combination with unfractionated heparin were given. Clinical and echocardiographic properties of the patients were collected before EKOS, at the end of EKOS and during the follow-up visit 6 months after discharge. The duration of EKOS treatment was 21.8 +/- 3.8 h and the total dose of tPA was 31.2 +/- 15.3 mg. One patient who presented with cardiac arrest died and the clinical status of the remaining subjects improved significantly. Any hemorrhagic complication was not observed. EKOS resulted in significant improvement of right ventricular functions and decrease of systolic pulmonary artery pressure. During a follow-up period of 6 months none of the patients died or suffered recurrent PE. In addition, echocardiographic parameters or right ventricular function significantly got better compared to in-hospital measurements. EKOS is an effective treatment modality for high risk PE patients with failed STT and can be applied with very low hemorrhagic complications.en_US
dc.identifier.citationSağ, S. vd. (2016). "Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis". Journal of Thrombosis and Thrombolysis, 42(3), 322-328.en_US
dc.identifier.endpage328tr_TR
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.issue3tr_TR
dc.identifier.pubmed27129723tr_TR
dc.identifier.scopus2-s2.0-84964614216tr_TR
dc.identifier.startpage322tr_TR
dc.identifier.urihttps://doi.org/10.1007/s11239-016-1370-3
dc.identifier.urihttps://link.springer.com/article/10.1007/s11239-016-1370-3
dc.identifier.urihttp://hdl.handle.net/11452/29512
dc.identifier.volume42tr_TR
dc.identifier.wos000382868700002tr_TR
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.journalJournal of Thrombosis and Thrombolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular system & cardiologyen_US
dc.subjectHematologyen_US
dc.subjectAcute pulmonary embolismen_US
dc.subjectFailed systemic thrombolytic treatmenten_US
dc.subjectCatheter directed thrombolysisen_US
dc.subjectEkoSonic endovascular systemen_US
dc.subjectEuropean-societyen_US
dc.subjectIntermediateen_US
dc.subjectEmbolectomyen_US
dc.subjectTherapyen_US
dc.subjectFragmentationen_US
dc.subjectFibrinolysisen_US
dc.subjectGuidelinesen_US
dc.subjectManagementen_US
dc.subjectCardiologyen_US
dc.subjectSafetyen_US
dc.subject.emtreeHeparinen_US
dc.subject.emtreeTissue plasminogen activatoren_US
dc.subject.emtreeAbsence of complicationsen_US
dc.subject.emtreeAcute pulmonary embolismen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCatheter directed thrombolysisen_US
dc.subject.emtreeCause of deathen_US
dc.subject.emtreeClinical articleen_US
dc.subject.emtreeClinical assessmenten_US
dc.subject.emtreeControlled clinical trialen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEchocardiographyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFlush catheteren_US
dc.subject.emtreeFollow upen_US
dc.subject.emtreeHeart arresten_US
dc.subject.emtreeHeart right ventricle functionen_US
dc.subject.emtreeHigh risk patienten_US
dc.subject.emtreeHospital dischargeen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeLung artery pressureen_US
dc.subject.emtreeLung embolismen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMechanical thrombectomyen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeProspective studyen_US
dc.subject.emtreeSystemic thrombolytic treatmenten_US
dc.subject.emtreeTreatment durationen_US
dc.subject.emtreeTreatment failureen_US
dc.subject.emtreeCatheteren_US
dc.subject.emtreeDevicesen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeFibrinolytic therapyen_US
dc.subject.emtreeMechanical thrombectomyen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreePulmonary embolismen_US
dc.subject.emtreeSalvage therapyen_US
dc.subject.emtreeTreatment outcomeen_US
dc.subject.emtreeUltrasound surgeryen_US
dc.subject.meshCathetersen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeparinen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMechanical thrombolysisen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshPulmonary embolismen_US
dc.subject.meshSalvage therapyen_US
dc.subject.meshThrombolytic therapyen_US
dc.subject.meshTissue plasminogen activatoren_US
dc.subject.meshTreatment outcomeen_US
dc.subject.meshUltrasonic surgical proceduresen_US
dc.subject.scopusLung Embolism; Embolectomy; Blood Clot Lysisen_US
dc.subject.wosCardiac & cardiovascular systemsen_US
dc.subject.wosHematologyen_US
dc.subject.wosPeripheral vascular diseaseen_US
dc.titleCatheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysisen_US
dc.typeArticle
dc.wos.quartileQ3en_US

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