Morphological and physiological findings of fetal adrenal grafts in rats who underwent bilateral staged adrenalectomy

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dc.contributor.buuauthorSanal, Murat
dc.contributor.buuauthorKırıştıoğlu, İrfan
dc.contributor.buuauthorDoğruyol, Hasan
dc.contributor.buuauthorKonca, Yıldız
dc.contributor.buuauthorÇavuşoğlu, İlkin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.tr_TR
dc.date.accessioned2021-07-12T06:35:39Z
dc.date.available2021-07-12T06:35:39Z
dc.date.issued1993
dc.description.abstractEarlier studies have shown successful transplantation of fetal grafts into the greater omentum of rats. This report evaluates the effects of fetal adrenal glands in adult rats, who underwent bilateral staged adrenalectomy. At first we carried out a preliminary study to investigate the outcome of bilateral adrenalectomy: There were three groups each consisting of 10 rats. In Group 1 we performed bilateral adrenalectomy, and all rats died postoperatively within 8 hours. In Group 2 the rats underwent sham procedure, and only one rat died. Group 3 was for control and all rats survived. After the preliminary study we constructed a 4th th group (Tx group) with 20 rats. We performed a left. adrenalectomy and immediately transplanted fetal adrenal glands into the greater omentum (stage 1). All animals survived the operation. After 6 weeks we did a second laparotomy and excised the right adrenal gland (stage 2). All of rats from Group 4 compared to Group 1 did not die postoperatively within 8 hours. 6 rats survived staged bilateral adrenalectomy with fetal grafts. Histologic investigation of fetal grafts revealed well developed cortex containing all three layers, but we could not find any medullary cells. In view of these findings we speculate that the fetal adrenal grafts have functioned in this model.en_US
dc.identifier.citationSanal, M. vd. (1993). ''Morphological and physiological findings of fetal adrenal grafts in rats who underwent bilateral staged adrenalectomy''. European Journal of Pediatric Surgery, 3(6), 339-342.en_US
dc.identifier.endpage342tr_TR
dc.identifier.issn0939-7248
dc.identifier.issnhttps://pubmed.ncbi.nlm.nih.gov/8110714
dc.identifier.issue6tr_TR
dc.identifier.pubmed8110714tr_TR
dc.identifier.scopus2-s2.0-0027742022tr_TR
dc.identifier.startpage339tr_TR
dc.identifier.urihttps://doi.org/10.1055/s-2008-1066040
dc.identifier.urihttp://hdl.handle.net/11452/21210
dc.identifier.volume3tr_TR
dc.identifier.wosA1993MN18000003tr_TR
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.journalEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPediatricsen_US
dc.subjectSurgeryen_US
dc.subjectTransplantationen_US
dc.subjectFetal graftsen_US
dc.subjectAdrenal graftsen_US
dc.subjectArticleen_US
dc.subjectAnimal tissueen_US
dc.subjectAnimal experimenten_US
dc.subjectAdrenalectomyen_US
dc.subjectAdrenal glanden_US
dc.subject.wosPediatricsen_US
dc.subject.wosSurgeryen_US
dc.titleMorphological and physiological findings of fetal adrenal grafts in rats who underwent bilateral staged adrenalectomyen_US
dc.typeArticle

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