5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia
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Date
2010-02
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Publisher
Oxford University
Abstract
Myeloid/lymphoid leukemia (MLL) gene rearrangements are high risk cytogenetic characteristics of acute lymphoblastic leukemia (ALL). Translocations of this gene are well defined, and their impact on the patient's prognosis is well known, but deletions of the same region are rare, and little is known about their prognostic significance and the significance of their accompanying translocations. Here we present a case of childhood ALL with a deletion of the 5' region of the MILL gene detected by fluorescence in situ hybridization (FISH) analysis, This result also confirmed the sensitivity and efficiency of FISH analysis.
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Keywords
MLL gene deletion, Acute Lymphoblastic Leukemia, FISH analysis, Hemotological malignancies, Rearrangement, Translocations, Identification, Abnormalities, Aberrations, Apoptosis, 11Q23, Probe, Fish, Medical laboratory technology
Citation
Gülten, T. vd. (2010). "5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia". Laboratory Medicine, 41(2), 83-86.