Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat
Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Monduzzi Editore
Abstract
In our study the effect of dexamethasone 3 hours before the hypoxic-ischemic brain damage were investigated in neonatal rats. 7 day old rats were undergone right CCA ligation followed by 2 hours hypoxic exposure. 7 day after the insult the brains were sectioned coronally +2, -2 mm from bregma and immersed in TTC. In vehicle treated group there was a marked infarction throughout cortex and striatum, disintegration of the structures of the right hemisphere and liquefication. In the Ist coronal slice 18.33% and in the IInd 32.76% of infarct area was detected. H&E and Nissl stainings also showed extensive neuronal degeneration. Dexamethasone group had no gross infarction and histopathological examination. showed only mild degree of ischemic changes.
Description
Bu çalışma, 6-11 Temmuz 1997 tarihleri arasında Amsterdam[Hollanda]'da düzenlenen 11. International Congress of Neurological Surgery'de bildiri olarak sunulmuştur.
Keywords
Neurosciences & neurology
Citation
Alkan, T. vd. (1997). "Dexamethasone prevents hypoxic-ischemic brain damage in the neonatal rat", ed. Monduzzi Editore. 11. International Congress of Neurological Surgery, 1-2, 1857-1860.