Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer
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Date
2002
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Publisher
Wiley
Abstract
Fragile sites are non-staining gaps and breaks on mammalian chromosomes. Several investigators have pointed out that these sites may act as factors that predispose to specific chromosomal rearrangements that are present in some cancer cases. The expression of common fragile sites induced by aphidicolin (Ape) was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 15 patients with lung cancer, 20 of their clinically healthy family members, and 20 age-matched normal controls. As a result of cytogenetic evaluation carried out by the High Resolution Banding (HRB) technique, 1q21, 2q33, 3p14, 7q32, 13q13, 16q23, 17q21, and 22q12 are defined as fragile sites in patients and relatives. The rate of total fragile sites and 2q33, 3p14, and 16q23 are statistically significant in both patients and relatives when compared with the control group. Therefore, our results showed that common fragile sites might be unstable factors in the human genome and they can be used as suitable markers for genetic predisposition to lung cancer.
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Keywords
Nonrandom distribution, Small cell lung cancer, Chromosome aberration, Chromosome aberration, Common fragile sites, Genetic pre-disposition, Peripheric blood lymphocyte cultures, Breast-cancershort arm, Expression frequency, Renal-cell, Fhit gene, Heterozygosity, Aphidicolin, Lymphocytes, Susceptibility, Oncology, Genetics & heredity, Toxicology, Mammalia
Citation
Karadağ, M. vd. (2002)."Chromosomal fragile sites and relationship between genetic predisposition to small cell lung cancer". Teratogenesis Carcinogenesis and Mutagenesis, 22(1), 31-40.