Adult-onset Langerhans cell histiocytosis confined to the skin
Date
2006
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
Langerhans cell histiocytosis (LCH) is a clonal, pleo-morphic disease of unknown aetiology, with theaccumulation of local or disseminated atypical histiocyticcells staining positively for S-100 and CD-1a, and causingdamage in the bones, lungs, mucocutaneous structuresand endocrine organs.1 The condition is generally dia-gnosed in infancy and childhood, but onset in adulthoodcan occasionally occur. The eruption is usually diffuse ormanifests as part of a multisystemic disease, and up to 25–50% of patients with LCH will present initially with acutaneous rash.1–5 Cutaneous manifestations are hetero-genous and similar both in children and adults.1,2 LCHconfined to the skin is uncommon among reported casesof adults.2–8 We describe a rare case of adult-onset LCHpresenting as cutaneous lesions located symmetrically onthe scalp, groin and inframammarian areas, and review theliterature for previous adult cases of isolated cutaneousLCH.
Description
Keywords
Dermatology, Cutivate, Deltacortril
Citation
Aydoğan, K. vd. (2006). ''Adult-onset Langerhans cell histiocytosis confined to the skin''. Journal of the European Academy of Dermatology and Venereology, 20(7), 890-892.