Nadir bir olgu: renal hücreli karsinom ile cushing hastalığı birlikteliği
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Date
2018-11-07
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Uludağ Üniversitesi
Abstract
Hipofiz bezinden adrenokortikotropik hormon (ACTH) salgılayan adenom, endojen Cushing hastalığının en sık görülen nedenidir. Renal hücreli karsinom (RCC) en sık görülen böbrek kanseridir ve bu kanser ile ilişkili birçok endokrinolojik anormallik olabilir. Renal hücreli karsinom tanısı alan hastalarda Cushing sendromu saptanabilirken Cushing hastalığı çok nadir görülür. Cushing hastalığının tanısı klinik semptomlar, endokrinolojik testler ve radyolojik bulguların değerlendirilmesi ile konur. Cushing hastalığında en etkili tedavi adenomun rezeksiyonudur ama makroadenomlarda rezeksiyon ile kür şansı daha düşüktür. Postoperatif dönemde kür sağlanamamış olgularda tedavi seçenekleri arasında radyoterapi, medikal tedaviler (bromokriptin, siproheptadin, ketakonazol, pasireotide gibi) veya bilateral adrenalektomi düşünülebilir. Burada Cushing hastalığı ile birlikte renal hücreli karsinom tanısı konulan bir hasta sunulacaktır.
Adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is the most common cause of endogenous Cushing’s disease. Renal cell carcinoma (RCC) is the most common renal cancer and there may be many endocrinologic abnormalities associated with this cancer. Cushing’s syndrome can be observed in patients who are diagnosed with renal cell carcinoma, although Cushing's disease is very rare. The diagnosis of Cushing's disease is made by the evaluation of clinical symptoms, endocrinological tests and radiological findings. The most effective treatment for Cushing's disease is adenomal resection, but the chance of cure with resection is lower in macroadenomas. Radiotherapy, medical treatments (such as bromocriptine, cyproheptadine, ketaconazole, pasireotide) or bilateral adrenalectomy may be considered in cases of not cured in the postoperative period. In this report, we present a patient with a diagnosis of Cushing’s disease and renal cell carcinoma.
Adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma is the most common cause of endogenous Cushing’s disease. Renal cell carcinoma (RCC) is the most common renal cancer and there may be many endocrinologic abnormalities associated with this cancer. Cushing’s syndrome can be observed in patients who are diagnosed with renal cell carcinoma, although Cushing's disease is very rare. The diagnosis of Cushing's disease is made by the evaluation of clinical symptoms, endocrinological tests and radiological findings. The most effective treatment for Cushing's disease is adenomal resection, but the chance of cure with resection is lower in macroadenomas. Radiotherapy, medical treatments (such as bromocriptine, cyproheptadine, ketaconazole, pasireotide) or bilateral adrenalectomy may be considered in cases of not cured in the postoperative period. In this report, we present a patient with a diagnosis of Cushing’s disease and renal cell carcinoma.
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Keywords
Cushing hastalığı, Renal hücreli karsinom, Renal cell carcinoma, Cushing sendromu, Cushing syndrome, Cushing's disease
Citation
Çalapulu, M. vd. (2018). ''Nadir bir olgu: renal hücreli karsinom ile cushing hastalığı birlikteliği''. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 44(3), 109-112.