The high potential of methyl laurate as a recyclable competitor to conventional toxic solvents in [3 + 2] cycloaddition reactions.

Abstract

In the present study, 21 fused isoxazolidines were synthesized in yields ranging from good to excellent. Methyl laurate was identified as the easily accessible optimal solvent medium for the reaction, and the related compounds were obtained through straightforward isolation techniques in a relatively short time frame (5-80 minutes). A comprehensive investigation was conducted utilizing various web platforms, encompassing ecological and environmental risk assessments, toxicity, pesticide similarity, and biodegradability of methyl laurate in comparison with a series of conventional organic solvents, water, some fatty acids and their derivatives. The findings of this investigation revealed that methyl laurate exhibited better green solvent properties when evaluated against other solvents.