Publication:
Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: An experimental rat model

dc.contributor.authorYümün, Gündüz
dc.contributor.authorKahraman, Cüneyt
dc.contributor.authorKahraman, Nail
dc.contributor.authorAkçılar, Aydın
dc.contributor.authorAkgül, Engin
dc.contributor.authorVural, Ahmet Hakan
dc.contributor.buuauthorYalçınkaya, Ulviye
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.researcheridAAH-8924-2021
dc.contributor.scopusid6508300295
dc.date.accessioned2022-12-05T11:23:41Z
dc.date.available2022-12-05T11:23:41Z
dc.date.issued2015-01-24
dc.description.abstractIntroduction: Hyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds. Material and methods: Thirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal injection of streptozotocin. The rats were divided into a control group, a hyperbaric oxygen group, a platelet-rich plasma group, and a combined therapy group. Platelet-rich plasma was applied just after the creation of the wound; hyperbaric oxygen treatment was carried out daily over 7 days. Wound healing was evaluated according to four parameters: ulcerations, epidermal thickness, density of dermal collagen fibers, and proliferation of dermal blood vessels. Results: The number of active ulcers in the combined therapy group was fewer than in the control group (p = 0.039), and the wound area was greatest in controls (p < 0.001). The epidermal thickness in platelet-rich plasma and combined therapy groups was non-significantly greater than in the control group (p = 0.097 and p = 0.074, respectively). The amount of fibrous collagen in these two groups was greater than in the control group (p = 0.002). Conclusions: Combined hyperbaric oxygen and platelet-rich plasma therapy was found to be successful in diabetic wound healing. The combination therapy had no additive effect in terms of angiogenesis and the development of new collagen fibers.
dc.identifier.citationYümün, G. vd. (2016). "Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model". Archives of Medical Science, 12(6), 1370-1376.
dc.identifier.endpage1376
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6
dc.identifier.pubmed27904531
dc.identifier.scopus2-s2.0-84992731500
dc.identifier.startpage1370
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.62905
dc.identifier.urihttps://www.archivesofmedicalscience.com/Effects-of-hyperbaric-oxygen-therapy-combined-with-platelet-rich-plasma-on-diabetic,53553,0,2.html
dc.identifier.urihttp://hdl.handle.net/11452/29668
dc.identifier.volume12
dc.identifier.wos000386539200026
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTermedia Publishing House
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalArchives of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & internal medicine
dc.subjectHyperbaric oxygen
dc.subjectPlatelet-rich plasma
dc.subjectCombination therapy
dc.subjectRandomized-trial
dc.subjectFoot ulcers
dc.subjectEpidemiology
dc.subjectDisease
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeCollagen fiber
dc.subject.emtreeControlled study
dc.subject.emtreeDiabetes mellitus
dc.subject.emtreeDiabetic wound
dc.subject.emtreeEpidermis
dc.subject.emtreeFemale
dc.subject.emtreeHyperbaric oxygen therapy
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeSkin blood vessel
dc.subject.emtreeThrombocyte rich plasma
dc.subject.emtreeTreatment outcome
dc.subject.emtreeUlcer
dc.subject.emtreeWound
dc.subject.emtreeWound healing
dc.subject.scopusHyperbaric Oxygen Therapy; Diabetic Foot; Wound Healing
dc.subject.wosMedicine, general & internal
dc.titleEffects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: An experimental rat model
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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