Publication: Comparison of uroprotective efficacy of mesna and amifostine in cyclophosphamide- induced hemorrhagic cystitis in rats
dc.contributor.author | Kanat, Özkan | |
dc.contributor.author | Kurt, Ender | |
dc.contributor.author | Yalçinkaya, Ülviye | |
dc.contributor.author | Evrensel, Türkkan | |
dc.contributor.author | Manavoğlu, Osman | |
dc.contributor.buuauthor | Kanat, Özkan | |
dc.contributor.buuauthor | Kurt, Ender | |
dc.contributor.buuauthor | YALÇINKAYA, ÜLVİYE | |
dc.contributor.buuauthor | EVRENSEL, TÜRKKAN | |
dc.contributor.buuauthor | Manavoǧlu, Osman | |
dc.contributor.department | Tıp Fakültesi, | |
dc.contributor.department | Tıbbi Onkoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0009-0000-6166-4466 | |
dc.contributor.scopusid | 55881548500 | |
dc.contributor.scopusid | 7006207332 | |
dc.contributor.scopusid | 6603942124 | |
dc.contributor.scopusid | 6508300295 | |
dc.contributor.scopusid | 6602587152 | |
dc.date.accessioned | 2025-05-13T14:14:33Z | |
dc.date.issued | 2006-01-01 | |
dc.description.abstract | Background:Hemorrhagic cystitis (HC) is a dose limiting side effect of cyclophosphamide (CYP). AIM: In this study, we aimed to investigate the role of amifostine in the protection of CYP-induced HC and compare its efficacy with mesna. SETTING AND DESIGN: This animal study was conducted in the Experimental Animals Breeding and Research Center of the Medical Faculty of Uludag University. MATERIALS AND METHODS: Male Wistar rats (150-200 g; 10 rats per group) were randomly assigned to four groups. Group I (control group) received no drugs, group II received CYP (200 mg/kg, i.p.) alone, group III received amifostine (200 mg/kg, i.p.) and CYP, and group IV received CYP and mesna (40 mg/kg, i.p.) immediately and 4 and 8 h after administration of CYP. Bladders of animals were assessed macroscopically and histologically 24 h later. Gross assessment for presence of edema and hemorrhage and histological evaluation of damage to the bladder were scored according to Gray′s criteria. STATISTICAL ANALYSIS USED: For macroscopic and microscopic data, we used statistical evaluation by Kruskal-Wallis nonparametric analysis of variance followed by the Mann-Whitney U-test. RESULTS: All the animals in group II had evidence of HC. Significant histological damage and macroscopic changes were present in this group compared to control group ( P P<0.001). The median scores for bladder damage in group III and IV were significantly lower compared to group II ( P<0.001). When the median scores for bladder damage of group I, III, and IV were compared, there was no significant difference among these groups. CONCLUSION: This study demonstrated the efficacy of amifostine in prevention of cyclophosphamide-induced hemorrhagic cystitis. | |
dc.identifier.doi | 10.4103/0019-509X.25769 | |
dc.identifier.endpage | 15 | |
dc.identifier.issn | 0019-509X | |
dc.identifier.issue | 1 | |
dc.identifier.scopus | 2-s2.0-33745121518 | |
dc.identifier.startpage | 12 | |
dc.identifier.uri | https://hdl.handle.net/11452/52822 | |
dc.identifier.volume | 43 | |
dc.indexed.scopus | Scopus | |
dc.language.iso | en | |
dc.publisher | Medknow Publications and Media Pvt. Ltd | |
dc.relation.journal | Indian Journal of Cancer | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Mesna | |
dc.subject | Hemorrhagic cystitis | |
dc.subject | Cyclophosphamide | |
dc.subject | Amifostine | |
dc.subject.scopus | Management Strategies for Hemorrhagic Cystitis in Patients | |
dc.title | Comparison of uroprotective efficacy of mesna and amifostine in cyclophosphamide- induced hemorrhagic cystitis in rats | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Tıbbi Onkoloji Ana Bilim Dalı | |
relation.isAuthorOfPublication | 88cde6d8-7aff-42a7-8102-4847acdacd8b | |
relation.isAuthorOfPublication | eceff514-6af7-4c3b-a146-b77546565a6c | |
relation.isAuthorOfPublication.latestForDiscovery | 88cde6d8-7aff-42a7-8102-4847acdacd8b |