Publication:
Comparison of uroprotective efficacy of mesna and amifostine in cyclophosphamide- induced hemorrhagic cystitis in rats

dc.contributor.authorKanat, Özkan
dc.contributor.authorKurt, Ender
dc.contributor.authorYalçinkaya, Ülviye
dc.contributor.authorEvrensel, Türkkan
dc.contributor.authorManavoğlu, Osman
dc.contributor.buuauthorKanat, Özkan
dc.contributor.buuauthorKurt, Ender
dc.contributor.buuauthorYALÇINKAYA, ÜLVİYE
dc.contributor.buuauthorEVRENSEL, TÜRKKAN
dc.contributor.buuauthorManavoǧlu, Osman
dc.contributor.departmentTıp Fakültesi,
dc.contributor.departmentTıbbi Onkoloji Ana Bilim Dalı
dc.contributor.orcid0009-0000-6166-4466
dc.contributor.scopusid55881548500
dc.contributor.scopusid7006207332
dc.contributor.scopusid6603942124
dc.contributor.scopusid6508300295
dc.contributor.scopusid6602587152
dc.date.accessioned2025-05-13T14:14:33Z
dc.date.issued2006-01-01
dc.description.abstractBackground:Hemorrhagic cystitis (HC) is a dose limiting side effect of cyclophosphamide (CYP). AIM: In this study, we aimed to investigate the role of amifostine in the protection of CYP-induced HC and compare its efficacy with mesna. SETTING AND DESIGN: This animal study was conducted in the Experimental Animals Breeding and Research Center of the Medical Faculty of Uludag University. MATERIALS AND METHODS: Male Wistar rats (150-200 g; 10 rats per group) were randomly assigned to four groups. Group I (control group) received no drugs, group II received CYP (200 mg/kg, i.p.) alone, group III received amifostine (200 mg/kg, i.p.) and CYP, and group IV received CYP and mesna (40 mg/kg, i.p.) immediately and 4 and 8 h after administration of CYP. Bladders of animals were assessed macroscopically and histologically 24 h later. Gross assessment for presence of edema and hemorrhage and histological evaluation of damage to the bladder were scored according to Gray′s criteria. STATISTICAL ANALYSIS USED: For macroscopic and microscopic data, we used statistical evaluation by Kruskal-Wallis nonparametric analysis of variance followed by the Mann-Whitney U-test. RESULTS: All the animals in group II had evidence of HC. Significant histological damage and macroscopic changes were present in this group compared to control group ( P P<0.001). The median scores for bladder damage in group III and IV were significantly lower compared to group II ( P<0.001). When the median scores for bladder damage of group I, III, and IV were compared, there was no significant difference among these groups. CONCLUSION: This study demonstrated the efficacy of amifostine in prevention of cyclophosphamide-induced hemorrhagic cystitis.
dc.identifier.doi10.4103/0019-509X.25769
dc.identifier.endpage15
dc.identifier.issn0019-509X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-33745121518
dc.identifier.startpage12
dc.identifier.urihttps://hdl.handle.net/11452/52822
dc.identifier.volume43
dc.indexed.scopusScopus
dc.language.isoen
dc.publisherMedknow Publications and Media Pvt. Ltd
dc.relation.journalIndian Journal of Cancer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMesna
dc.subjectHemorrhagic cystitis
dc.subjectCyclophosphamide
dc.subjectAmifostine
dc.subject.scopusManagement Strategies for Hemorrhagic Cystitis in Patients
dc.titleComparison of uroprotective efficacy of mesna and amifostine in cyclophosphamide- induced hemorrhagic cystitis in rats
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Onkoloji Ana Bilim Dalı
relation.isAuthorOfPublication88cde6d8-7aff-42a7-8102-4847acdacd8b
relation.isAuthorOfPublicationeceff514-6af7-4c3b-a146-b77546565a6c
relation.isAuthorOfPublication.latestForDiscovery88cde6d8-7aff-42a7-8102-4847acdacd8b

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