Evaluation of the effect of buparvaquone used in the treatment of neonatal calves naturally infected with Cryptosporidium Spp. on renal and hepatic functions

Abstract

Cryptosporidium parvum is a zoonotic protozoan that causes neonatal calf diarrhea common in the world. Buparvaquone, which is known to have very positive effects on oocysts, which are the main reserve in the spread of infection, has not yet been investigated for its hemato-biochemical aspect in calves with cryptosporidiosis. In the present study, the effect of buparvaquone on renal and hepatic functions in naturally infected newborn calves with cryptosporidiosis was investigated. A group was formed for this study using only a total of ten calves (n=10) naturally infected with cryptosporidiosis. Buparvaquone 2.5 mg/kg intramuscular injection was administered as a single dose to all calves in the group. Laboratory analyses and statistical calculations of blood and serum samples taken on the specified days were made. According to the results we obtained in the study, it was observed that the renal and hepatic effects of the drug after a single dose injection of buparvaquone to calves with neonatal cryptosporidiosis remained within normal limits, similar to the methods safely applied in the treatment of cryptosporidiosis in the field.