Person: UÇAN GÜNDÜZ, GAMZE
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UÇAN GÜNDÜZ
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GAMZE
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Publication Efficacy of dexamethasone implants in uveitic macular edema in cases with behcet disease(Karger, 2019-01-01) Yalçınbayır, Özgür; Çalışkan, Enver; Gündüz, Gamze Uçan; Gelişken, Öner; Kaderli, Berkant; Yücel, Ahmet Ali; YALÇINBAYIR, ÖZGÜR; Çalışkan, Enver; UÇAN GÜNDÜZ, GAMZE; YÜCEL, AHMET ALİ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; JAC-9459-2023; EQX-5743-2022; AAH-6661-2021; JYV-1141-2024Purpose: Investigation of the efficacy of intravitreal dexamethasone implants (0.7 mg) in patients with Behcet disease (BD) who had cystoid macular edema (CME) despite immunomodulatory treatment. Materials and Methods: Twenty-seven eyes of 20 patients who had intravitreal dexamethasone implant injections and follow-up for more than 6 months were included in this study. Best corrected visual acuities (BCVA), intraocular pressures (IOP), and central macular thicknesses (CMT) were recorded. Systemic immunomodulatory treatment was noted. Injection-related complications and the need for recurrent injections were recorded. Results: Statistically significant anatomical and functional success was achieved with a single injection. BCVA increased from 0.85 +/- 0.72 to 0.45 +/- 0.52 logMAR, while the mean CMT decreased from 406 +/- 190 to 243 +/- 101 mu m at the sixth month. The peak of visual acuity gain was reached within the first 2 months and a substantial proportion of the patients gained 3 or more lines. There was no complication other than transient IOP elevation in 4 eyes and cataract surgery in 2 eyes. Conclusion: Adjuvant intravitreal dexamethasone implant injections offer promising results in cases of BD with CME. It is effective in preserving the macular anatomy and vision particularly in transition to biological agents.Publication A rare case of recurrence presenting with bilateral exudative retinal detachment in a child with acute lymphoblastic leukemia(Wiley, 2021-08-16) Yalçınbayır, Özgür; Sezgin Evim, Melike; Uçan Gündüz, Gamze; Güler, Salih; Meral Güneş, Adalet; YALÇINBAYIR, ÖZGÜR; SEZGİN EVİM, MELİKE; UÇAN GÜNDÜZ, GAMZE; GÜLER, SALİH; MERAL GÜNEŞ, ADALET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji Anabilim Dalı; 0000-0002-7311-5277; 0000-0002-1219-8304; 0000-0002-5458-1686; 0000-0002-4792-269X; 0000-0002-0686-7129; IYJ-9408-2023; AAH-1452-2021; AAH-6661-2021; DWH-8632-2022; EXD-8400-2022Publication Clinical outcomes of posterior segment intraocular foreign bodies: The volume effect(Masson Editeur, 2021-05-12) Gündüz, Gamze Uçan; Yalçınbayir, Özgür; Güllülü, Zeynep Zahide; Özkaya, Gamze; UÇAN GÜNDÜZ, GAMZE; YALÇINBAYIR, ÖZGÜR; GÜLLÜLÜ, ZEYNEP ZAHİDE; ÖZKAYA, Gamze; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İstatistik Anabilim Dalı; 0000-0002-7311-5277; 0000-0003-0297-846X; 0000-0002-1219-8304; AAH-6661-2021; IYJ-9408-2023; FAZ-3274-2022; A-4421-2016Purpose. - To assess the effect of foreign body volume on visual and anatomic outcomes in patients with a posterior segment intraocular foreign body (IOFB).Methods. - Patients were divided into three groups according to the volume of the IOFB; group 1 (n = 18 eyes) with IOFBs< 2 mm(3), group 2 (n = 15 eyes) with 2 mm(3) <= IOFBs < 6 mm(3), group 3 (n = 18 eyes) with IOFBs >= 6 mm(3). AU eyes underwent pars plana vitrectomy (PPV) for removal of the IOFB. Demographic characteristics, features of the injury and IOFB, findings of the initial and final ophthalmological examinations, and timing of IOFB removal were studied.Results. - The mean age was 38.8 +/- 12.0 years, and the median follow-up period was 12.0 (range: 6-98) months. Initial visual acuity (VA) was significantly lower in group 3 (P= 0.005), while final VA was similar between the three subgroups. Frequencies of primary globe repair, initial vitreous hemorrhage (VH), corneoscleral entry, and IOFB removal through the cornea were significantly higher in eyes with large volume IOFBs (P<0.05). Siderosis was only seen in 4 patients in group 1 (22.2%). No patients developed postoperative endophthalmitis.Conclusion. - Large volume posterior segment IOFBs are associated with poor initial VA, initial VH and corneoscleral injury. Nevertheless, PPV and IOFB extraction under favorable conditions may provide significant visual improvement in eyes with large volume IOFBs. (C) 2021 Elsevier Masson SAS. All rights reserved.Publication Anti-tumor necrosis factor treatment in the management of pediatric noninfectious uveitis: Infliximab versus adalimumab(Mary Ann Liebert, Inc, 2021-01-28) Uçan Gündüz, Gamze; Yalçınbayır, Özgür; Çekiç, Şükrü; Yiıdız, Meral; Kılıç, Sara Şebnem; UÇAN GÜNDÜZ, GAMZE; YALÇINBAYIR, ÖZGÜR; ÇEKİÇ, ŞÜKRÜ; YILDIZ, MERAL; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Alerji ve Klinik İmmünoloji; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0002-9574-1842; 0000-0001-8571-2581; AAH-1885-2021; AAH-6625-2021; AAH-6661-2021; IYJ-9408-2023; AAH-1658-2021; JAC-9459-2023; L-1933-2017Purpose: Management of uveitis displays a particular challenge in childhood. This study aims to compare the efficacy and safety of infliximab (IFX) and adalimumab (ADA) in pediatric noninfectious uveitis that were refractory to conventional immunosuppresives.Methods: This retrospective single-center study included 33 patients who were treated with anti-tumor necrosis factor (TNF) agents (16 with IFX and 17 with ADA). Patients had diverse etiologies, including juvenile idiopathic arthritis, idiopathic uveitis, and Behcet's disease. Demographic characteristics, systemic diagnosis, findings of the ophthalmological examination, control of ocular inflammation, response to treatment, and the rate of clinical remission were studied.Results: Fourteen (87.5%) patients receiving IFX and 10 (58.8%) patients receiving ADA achieved response to treatment during the follow-up (P = 0.118). The agents were discontinued with complete clinical remission in 6 (37.5%) patients receiving IFX and in 2 (11.8%) patients receiving ADA (P = 0.118). Baseline visual acuities and parameters of inflammation improved significantly in both groups after anti-TNF therapy.Conclusion: Both IFX and ADA are safe and effective for pediatric noninfectious uveitis.Publication Floppy eyelid syndrome: Clinical findings and results of lateral pentagonal eyelid resection(Turkish Ophthalmological Soc, 2010-12-01) Oral, Deniz; Çiftçi, Ferda Ozgun; Gündüz, Gamze Uçan; UÇAN GÜNDÜZ, GAMZE; Yazıcı, Bülent; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0002-5458-1686; 0000-0001-8889-1933; AAH-6661-2021; AAA-5384-2020Purpose: To report the demographic and clinical characteristics of patients with floppy eyelid syndrome and to review the results of eyelid shortening through lateral pentagonal eyelid resection.Material and Method: Thirty patients who had been diagnosed with floppy eyelid syndrome between January 2001 and January 2009 in two clinical centers were evaluated retrospectively. Presenting symptoms, examination findings, body mass index, associated systemic problems, surgical results and follow-up time were recorded. Surgical correction of horizontal laxity was performed on 23 upper eyelids of 15 patients by full-thickness lateral pentagonal wedge resection.Result: Fifty-eight upper eyelids of 30 patients (mean age, 59 years) were induded in the study. Irritation (93%) and epiphora (79%) were the most common presenting symptoms. Based on body mass index, 20 patients (67%) were obese and 19 patients (63%) had a history of obstructive sleep apnea. After surgery, ocular surface symptoms significantly resolved or decreased in all eyes. In 1 eye (4%), in which ocular complaints recurred, a secondary eyelid shortening procedure was required for residual lid laxity 12 months after the first surgery. Follow-up time ranged from 2 to 37 months (mean, 15 months).Discussion:The results of this study support the idea that obesity and/or sleep apnea syndrome occur more frequently in patients with floppy eyelid syndrome and eyelid shortening with lateral pentagonal resection is an effective treatment method.Publication Herpes zoster ophthalmicus and lateral rectus palsy in an elderly patient(Karger, 2011-01-01) Yalçınbayır, Özgür; Yıldız, Meral; Gündüz, Gamze Ucan; Gelişken, Öner; YALÇINBAYIR, ÖZGÜR; YILDIZ, MERAL; UÇAN GÜNDÜZ, GAMZE; Gelişken, Öner; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0002-7311-5277; 0000-0002-5458-1686; HPH-3842-2023; AAH-6661-2021; KBU-8934-2024; EXE-4887-2022Acquired palsy of the lateral rectus presents with horizontal diplopia and has a broad differential. Herpes zoster ophthalmicus-(HZO) related cranial nerve palsy is a transient and self-limiting condition. Systemic antiviral treatment is administered in order to prevent sight-threatening complications. In suspected cases, zosteriform rash should be questioned. One should keep in mind that acquired esotropia in the elderly may sometimes present following HZO.Publication Different cases, different manifestations of post-covid-19 retinal artery occlusion: A case series(Galenos Publ House, 2023-04-01) Yalçınbayır, Özgür; YALÇINBAYIR, ÖZGÜR; Gündüz, Gamze Uçan; UÇAN GÜNDÜZ, GAMZE; Coşkun, Funda; COŞKUN, NECMİYE FUNDA; Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; DOĞANAY, SELİM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Oftalmloloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pulmoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-7311-5277; 0000-0002-5458-1686; 0000-0003-3604-8826; IYJ-9408-2023; AAD-1271-2019; AAH-6225-2021Coronavirus disease 2019 (COVID-19) is a procoagulant disease that increases the risk of clinically evident thrombotic complications. Herein we present 3 cases with different retinal artery occlusions that emerged soon after the diagnosis of COVID-19. The first patient had central retinal artery occlusion (CRAO) that resulted in visual loss in one eye. The second patient had inflammatory peripheral retinal artery occlusion, vasculitis, and uveitis which did not affect vision. The third patient presented with CRAO following the progression from orbital cellulitis to orbital apex syndrome. Interestingly, CRAO progressed to internal carotid artery occlusion in this case within days and resulted in monocular visual loss. Variations in the underlying pathophysiology and the characteristics of individual immune responses in patients with COVID-19 may be factors that determine differences in clinical manifestations. This article aims to describe different presentations of COVID-19-related retinal artery occlusions and discuss possible pathophysiological aspects.Publication Basal cell carcinoma in a full-thickness skin graft in the upper eyelid(Taylor & Francis Inc, 2011-01-01) Yazıcı Bülent; Gönen, Tansu; Uçan, Gamze; UÇAN GÜNDÜZ, GAMZE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0001-8889-1933; 0000-0002-5458-1686; AAH-6661-2021; AAA-5384-2020A 75-year-old woman presented with a nodular lesion on a skin graft in her left upper eyelid. The lesion had grown gradually over the previous 2 years. She had undergone multiple surgeries and full-thickness skin graft procedures 61 years previously, because of cutaneous leishmaniasis. The diagnosis of nodular basal cell carcinoma was made by means of an excisional biopsy of the lesion. During a follow-up period of 27 months, the tumor did not recur. Malignant tumors may rarely develop at the site of traumatic or surgical scar. To our knowledge, this is the first reported case of basal cell carcinoma arising in a skin graft in the eyelid.Publication Reconstruction of periocular defects with rhomboid flap: Surgical results(Turkish Ophthalmological Soc, 2012-07-01) Dirim, Ayşe Burcu; Yazıcı, Bülent; Gündüz, Gamze Uçan; UÇAN GÜNDÜZ, GAMZE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıklar Anabilim Dalı.; 0000-0001-8889-1933; 0000-0002-5458-1686; AAA-5384-2020; AAH-6661-2021Purpose: To review the surgical results in patients who underwent an eyelid reconstruction with rhomboid flap after periorbital and medial canthal tumor excision.Material and Method: This study included 18 patients who underwent eyelid reconstruction with rhomboid flap after periorbital and medial canthal tumor excision. The patient charts were reviewed for topographic data, tumor features, surgical technique, and postoperative results.Results: The mean age of the patients (10 women, 8 men) was 58 years (age range: 22-78 years). The lesion was located in the inferior periorbital-malar area in 8 patients, in the medial canthal area in 8 patients and in the lateral periorbital area in 2 patients. Mean tumor diameter was 8.9 mm (range: 5-13.5 mm). Rhomboid flap was used alone in 14 patients (78%) and in combination with nazojugal advanced flap and semicircular flap in 2 patients (11%) each. The skin defect could be closed primarily in all patients, except one. A secondary surgical intervention was required for ectropion and pyogenic granuloma excision in 1 patient each. The aesthetic outcome was satisfactory in all patients. Mean follow-up time was 23 months (range: 2-64 months).Discussion: Rhomboid flap can be used for medial canthal and periorbital eyelid reconstruction after tumor excision. This flap technique can be combined with other reconstruction methods for large defects. After surgery, aesthetic and functional results are satisfactory in most patients, whereas surgical complications and need for a secondary surgery are rare.Publication Treatment of dural carotid-cavernous sinus fistula through the superior ophthalmic vein(Turkish Ophthalmological Soc, 2011-10-01) Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; Uçan, Gamze; UÇAN GÜNDÜZ, GAMZE; Yazıcı, Bülent; Türüdü, Sevil; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-5458-1686; 0000-0001-8889-1933; AAI-2318-2021; AAH-6661-2021; AAA-5384-2020Purpose: To present 3 patients who had a dural carotid-cavernous sinus fistula (CCF) and underwent cavernous sinus embolization through superior ophthalmic vein (SOV) approach.Material and Method.: Medical records of 3 patients with dural CCF who were treated through SOV approach were reviewed. Patient's age, gender, ophthalmic and radiological findings, treatment results, postoperative complications and follow-up time were recorded. Surgical procedure was performed in the interventional radiology unit and using general anesthesia. Through an eyelid crease incision, the SOV was reached and cannulated. The cavernous sinus was embolized with metalic coils advanced through a microcatheter placed into this cannun.Results: All 3 patients (3 female, patient ages: 41, 68 and 71 years) had Barrow type D CCF. One patient had a bilateral CCF. All patients had a history of unsuccessful treatment with interventional transvenous routes. The embolization procedure via the SOV was successfully completed in 2 patients. In a patient with bilateral CCF, the SOV was thin and tortuous, and could not be cannulated. All ophthalmic symptoms were improved in 2 patients with a successful embolization, and did not recur during the follow-up periods of 24 and 22 months. In one of these, an ischemic cerebrovascular event and orbital hematoma developed after the embolization. These complications improved without leaving a permanent impairment.Discussion: Cavernous sinus embolization can be performed through SOV approach, when it can not be done via the interventional transvenous routes. This procedure may not be successfully performed in some cases because of the anatomical features of the SOV. After the operation, complications such as orbital hemorrhage and cerebral ischemic attack may occur.