Person: SIĞIRLI, DENİZ
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SIĞIRLI
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DENİZ
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Publication Statistical shape analysis of putamen in early-onset Parkinson's disease(Elsevier, 2021-10) Sığırlı, Deniz; Özdemir, Senem Turan; Erer, Sevda; Şahin, İbrahim; Ercan, İlker; Özpar, Rifat; Örün, Muhammet Okay; Hakyemez, Bahattin; SIĞIRLI, DENİZ; ERER ÖZBEK, ÇİĞDEM SEVDA; ERCAN, İLKER; ÖZPAR, RİFAT; HAKYEMEZ, BAHATTİN; Özdemir, Senem Turan; Şahin, İbrahim; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-9031-3040; 0000-0002-3425-0740; 0000-0001-6649-9287; AAA-7472-2021; FPU-9468-2022; DVY-9744-2022; HII-7787-2022; ABF-2367-2020; AAH-5062-2021; AAI-2318-2021Objective: To investigate the shape differences in the putamen of early-onset Parkinson's patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities. Methods: This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson's patients and age and gender matched control subjects. Landmark coordinate data obtained and Procrustes analysis was used to compare mean shapes. The relationships between the centroid sizes of the left and right putamen, and the durations of disease examined using growth curve models. Results: While there was a significant difference between the right putamen shape of control and patient groups, there was not found a significant difference in terms of left putamen. Sub-regional analyses showed that for the right putamen, the most prominent deformations were localized in the middle-posterior putamen and minimal deformations were seen in the anterior putamen. Conclusion: Although they were not as pronounced as those in the right putamen, the deformations in the left putamen mimic the deformations in the right putamen which are found mainly in the middle-posterior putamen and at a lesser extend in the anterior putamen.Publication Predictors of drug survival of biologic therapies in psoriasis patients (vol 45, pg 813, 2020)(Taylor & Francis, 2020-08-31) Zorlu, Özge; Başkan, Emel Bülbül; BÜLBÜL BAŞKAN, EMEL; Yazıcı, Serkan; YAZİCİ, SERKAN; Sığırlı, Deniz; SIĞIRLI, DENİZ; Budak, Ferah; BUDAK, FERAH; Sarıcaoğlu, Hayriye; SARICAOĞLU, HAYRİYE; Aydoğan, Kenan; AYDOĞAN, KENAN; Cevhertas, Laçin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim; 0000-0001-5555-130X; 0000-0001-6407-0962; 0000-0001-7625-9148; 0000-0002-0193-1128; 0000-0003-2287-3569; AAH-1388-2021; AAH-6216-2021; AAA-7472-2021; F-4657-2014; IZP-9398-2023; AAH-2459-2021Publication Assessment of neurodegeneration by optical coherence tomography and mini-mental test in parkinson's disease(Wolters Kluwer Medknow Publications, 2019-04-01) Yıldız, Demet; Pekel, Nilufer Büyükkoyuncu; Yener, Neslihan Parmak; Seferoğlu, Meral; Güneş, Aygül; Sığırlı, Deniz; SIĞIRLI, DENİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAA-7472-2021Background: Parkinson's disease is a neurodegenerative disease. Cognitive disorders and retinal degeneration may occur during the early stages of the disease. Retinal degeneration and cognitive findings can be assessed easily with optical coherence tomography and mini-mental test, respectively. Materials and Methods: Twenty-two patients who are being followed-up with Parkinson's disease and 22 healthy controls have been included in the study. The Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr staging of the patients have been conducted at the time of admission. Retinal nerve fiber layer analysis and ganglion cell thickness (ganglion cell complexes [GCCs]) were evaluated through optical coherence tomography (OCT). And at the same time, we aimed to compare the stage of the disease, the UPDRS score and the duration of the disease with OCT and cognitive functions by mini-mental test. Results: Mini-mental test total score value (P = 0.025) and language value (P = 0.021) were lower in the patient group compared to the control group. In patients, there is a reverse significant correlation between UPDRS-T and GCC-left-superior (r = -0.495; P = 0.026), GCC-left-inferior (r = -0.517; P = 0.019), and GCC-left-to (r = -0.508; P = 0.022). There is a significant parallel relation between recall and RFNL-right-mean (r = 0.626; P = 0.039). Conclusion: Our findings indicate that the neurodegeneration continues multisystemically and neurodegeneration increases simultaneously with the disease. OCT, which is a noninvasive method, can be used as an indicator of neurodegeneration in patients with P arkinson's disease.Publication Relationship of magnesemia with myocardial damage and mortality in patients with COVID-19(John Libbey Eurotext Ltd, 2021-07-01) Günay, Şeyda; Çalışkan, Serhat; Sığırlı, Deniz; Günay, Şeyda; SIĞIRLI, DENİZ; 000-0003-0012-345X; AAI-5350-2021; AAA-7472-2021Background: Magnesium (Mg) is the second most abundant intracellular cation and plays a significant role in immune system and cardiac protection. Mg deficiency contributes to chronic low-grade inflammation leading to cardiovascular diseases, and low Mg level exacerbates virus-induced inflammation. Aim: The aim of the study was to investigate whether serum magnesium level is associated with myocardial damage and prognosis of COVID-19. Method: This was a single-center, observational retrospective study of patients with COVID-19. The study population was divided into two groups according to in-hospital mortality: a survivor group (SG) and a non-survivor group (NSG). Myocardial damage was defined as blood levels of cardiac troponin I (cTnI) above the 99th percentile upper reference limit. Magnesium, variables regarding inflammation, and myocardial damage were compared between the groups. Results: A total of 629 patients with COVID-19 were included. Mortality rate was 11.85% (n = 82). There were 61 (74.4%) and 294 male patients (53.7%) in NSG and SG, respectively (p = 0.001). The median age of NSG was 64.5 years (min-max: 37-93) and the median age of SG was 56.0 years (min-max: 22-92) (p < 0.001). Median serum magnesium levels of NSG and SG were 1.94 mg/dL (min-max: 1.04-2.87) and 2.03 mg/dL (min-max: 1.18-2.88), respectively (p = 0.027). Median cTnI levels of NSG and SG were 25.20 pg/mL (min-max: 2.10-2240.80) and 4.50 pg/mL (min-max: 0.50-984.3), respectively (p < 0.001). The cTnI levels were lower in those patients whose serum Mg levels were higher than 1.94. Conclusion: Although serum magnesium level was not a predictor for in-hospital mortality, there was a significant negative correlation between magnesemia and myocardial damage.Publication Evaluation of the corpus callosum shape in patients with obstructive sleep apnea(Springer Heidelberg, 2021-09-28) Güneş, Aygül; Sığırlı, Deniz; Ercan, İlker; Turan Özdemir, Senem; Durmuş, Yavuz; Yıldiz, Tekin; SIĞIRLI, DENİZ; ERCAN, İLKER; Turan Özdemir, Senem; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; AAA-7472-2021; ABF-2367-2020; FPU-9468-2022Background The aim of this study was to examine whether or not there was a difference in corpus callosum shape between patients with mild to moderate and severe obstructive sleep apnea (OSA) compared with patients who have simple snoring.Methods The landmark coordinate data was obtained from the mid-sagittal magnetic resonance imaging (MRI) images of 70 patients who underwent polysomnography. For comparisons, mild and moderate OSA groups were combined and analyses were performed on three groups; simple snoring/control group, mild or moderate OSA group, and severe OSA group.Results The corpus callosum shape of controls was significantly different from that of the severe OSA group. The most prominent deformities were observed in the genu and rostral body of the corpus callosum for the patients with severe OSA. No significant difference was found between mild/moderate OSA group and simple snoring group in terms of global corpus callosum shape.Conclusion The data demonstrated that severe OSA patients have structural changes in the corpus callosum and deformities may vary as the severity of disease changes.Publication Relationship between pet/ct response and survival in patients with non-small-cell lung cancer treated with definitive chemoradiotherapy(Akad Doktorlar Yayınevi, 2021-01-01) Sarıhan, Süreyya; Bilgin, Gökçe Beige; Sığırlı, Deniz; SARIHAN, SÜREYYA; Bilgin, Gökçe Beige; SIĞIRLI, DENİZ; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı; 0000-0003-4816-5798; AAH-4970-2021; EMG-1218-2022; AAA-7472-2021We aimed to evaluate the relationship between PET/CT response and survival in patients with non-small cell lung cancer (NSCLC) treated with curative chemoradiotherapy. Between January and December 2012, 51 patients were treated. The median age was 61 (29-79) and the M/F ratio was 46/5. Eighty two percent of the cases were stage III and 53% were squamous cell carcinoma. Median 6300 cGy (4860-7525) radiotherapy delivered and 92% of patients received chemotherapy. The median follow-up was 27 months (7-96 months) in November 2019. The objective response was 71% with CT at 1 month and 76% with PET/CT at 3 months. There was a significant correlation between response-1 and response-3 (p< 0.001). Tumor SUVmean3 < 2.81, SUVmax change >= 70% was associated with response-1 (p< 0.05). The median and 5-year overall (OS) and progression-free (PFS) survival rates were 54 months, 40% and 35 months, 38%, respectively. In Cox model, for each 1 unit increase, SUVmeanbase (HR: 1.18, 95% CI: 1.01-1.38) and SUVmean3 (HR: 2.65, 95% CI: 1.24-5.66) were found unfavorable factors for OS, whereas SUVmean3 (HR: 2.01, 95% CI: 1.02-3.93) was also found to be a poor prognostic factor for PFS. PET/CT parameters can be used as useful markers for prognosis in patients with NSCLC undergoing curative chemoradiotherapy. It is believed that early assessment during and after treatment can be advantageous in terms of treatment modification.Publication Covid-19 pandemic and anxiety related factors in patients treated in the emergency department(Mre Press, 2020-10-01) Durak, Vahide Aslihan; DURAK, VAHİDE ASLIHAN; Günay, Seyda; GÜNAY POLATKAN, ŞEYDA; Sığırlı, Deniz; SIĞIRLI, DENİZ; Akova, Bedrettin; AKOVA, BEDRETTİN; Armağan, Erol; ARMAĞAN, EROL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi /Spor Hekimliği Anabilim Dalı; 0000-0003-0836-7862; 0000-0003-1044-8805; AAA-7472-2021; AAI-4550-2021; AAH-8846-2021; AAI-5350-2021Aims: A novel coronavirus, now known as SARS-CoV-2019, suddenly emerged in Wuhan, China and within threemonths of the initial outbreak, the virus had spread rapidly to neighboring countries causing a pandemic. After the first case was announced, emergency departments were immediately reorganized as pandemic clinics. Special areas with maximum precautions were designed to evaluate patients. The majority of studies on this pandemic have focused on the treatment of respiratory symptoms and comorbidities in intensive care units. In this study, we sought to determine those factors that contributed to the anxiety level during the COVID-19 pandemic using the 'State' subscale of State-Trait Anxiety Inventory (STAI-S). Methods: A survey was performed in the emergency department by using an online questionnaire which consisted of demographic variables, questions about the opinions and behaviors of patients during the pandemic, diagnostic test results for COVID-19, and treatment methods. Results: There was a statistically significant difference between employment status (p < 0.001), monthly income (p < 0.001), the food consumption changes during the pandemic period (p = 0.001) and the estimated end-date for the COVID-19 pandemic (p < 0.001) and total STAI-S points. Conclusions: Our study has identified factors which significantly increase anxiety during the COVID-19 pandemic and identified those individuals who may benefit from psychiatric and social support.Publication Combining binary and continuous biomarkers by maximizing the area under the receiver operating characteristic curve(Taylor & Francis, 2020-03-08) Ahmadian, Robab; Ercan, İlker; Sığırlı, Deniz; Yıldız, Abdulmecit; Ahmadian, Robab; ERCAN, İLKER; SIĞIRLI, DENİZ; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0003-1550-639X; 0000-0002-2382-290X; AAE-5602-2019; ABF-2367-2020; AAA-7472-2021; ABF-2368-2020In any clinical case, a decision is made with the maximum possible accuracy. To achieve such accuracy, in the presence of multiple diagnostic tests or biomarkers, biomarker combinations aim to achieve maximum accuracy. As existing biomarker combination methods combine only continuous biomarkers, therefore in this study biomarker combination for binary biomarkers was created by suggesting an approach using Youden's J statistic for combining binary biomarkers. The proposed approach will facilitate binary and continuous biomarker combinations. A simulation study was conducted to compare the performance of our proposed combination approach according to different sample sizes. Both in the analysis of real data and the simulation studies for different samples, the proposed approach has been shown to yield favorable results and higher area under the curve.Publication Associations between olfactory impairment and cognitive functions in patients with parkinson disease(Turkish Neuropsychiatry Assoc-turk Noropsikiyatri Dernegi, 2020-09-01) Pekel, Nilufer Büyükkoyuncu; Yıldız, Demet; Taymur, İbrahim; Budak, Ersin; Özmen, Suay; Capkur, Cağla; Seferoğlu, Meral; Güneş, Aygul; Sığırlı, Deniz; SIĞIRLI, DENİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAA-7472-2021Introduction: Olfactory impairment and cognitive impairment are common non-motor symptoms in Parkinson's disease (PD). Olfactory impairment may be present even many years before the main symptoms of the disease develop. The associations between olfactory loss and cognition in PD are evaluated in this study.Methods: 31 patients with PD and 31 healthy subjects were included in this study. The Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr Scale (H&Y Scale) were administered to all subjects. Butanol threshold test and Sniffin'Sticks test were used to assess olfaction. The Mini Mental State Examination (MMSE) and Clock Drawing Test (CDT) and Stroop Color Word Test (SCWT) were used to assess cognition.Results: The Sniffin'Sticks test scores were significantly lower in the Parkinson group in comparison to the control group (p<0.001). The rate of anosmia was 90% in the PD group while this rate was found to be 54.8% in control group (p=0.005). A significant correlation was found between butanol test scores and stoop 5 and 5 errors. Significant correlations were found between the Sniffin'Sticks scores and MMSE scores (p=0.047) and orientation (p=0.041) and language (p=0.003) functions of the MMSE test. Worse olfaction was associated with worse memory.Conclusions: In PD, olfactory impairment correlates with cognitive impairment and olfactory tests may be used to predict the likelihood of developing dementia in this patient population.