Person: TERZİ, ORKUN ERAY
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TERZİ
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ORKUN ERAY
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Publication Il-21: A potential biomarker for diagnosis and predicting prognosis in covid-19 patients(European Respiratory Society Journals, 2021-09-05) Öztürk, Nilüfer Aylin Acet; Ursavaş, Ahmet; Dilektaşlı, Aslı Görek; Demirdöğen, Ezgi; Coşkun, Funda; Ediger, Dane; Uzaslan, Esra; Yöyen-Ermiş, Diğdem; Karaca, Mert; Terzi, Orkun; Bayram, Merve; Ömer, Dilara; Yiğitliler, Büşra; Yurttaş, Ahmet; Maharramov, Shahriyar; Çelik, Gamze; Oral, Barbaros; Karadağ, Mehmet; ACET ÖZTÜRK, NİLÜFER AYLİN; URSAVAŞ, AHMET; GÖREK DİLEKTAŞLI, ASLI; DEMİRDÖĞEN, EZGİ; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; YÖYEN ERMİŞ, DİĞDEM; KARACA, MERT; TERZİ, ORKUN ERAY; BAYRAM, MERVE; ÖMER TOPÇU, DİLARA; YURTTAŞ, AHMET; ORAL, HALUK BARBAROS; KARADAĞ, MEHMET; MAHARRAMOV, SHAHRİYAR; YAZICI, GAMZE; Tıp Fakültesi; 0000-0002-6375-1472; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0002-2954-4293; 0000-0001-5871-8769; 0000-0002-9027-1132; AAG-8744-2021; JPK-7012-2023; AAH-3888-2021; AAE-9142-2019; AAI-3169-2021; AAD-1271-2019Publication Development and validation of a simple risk scoring system for a COVİD-19 diagnostic prediction model(Tüberküloz ve Toraks, 2023-01-01) Güçlü, Özge Aydın; Ursavaş, Ahmet; Ocakoğlu, Gokhan; Demirdogen, Ezgi; Öztürk, Nilufer Aylin Acet; Topçu, Dilara Ömer; Terzi, Orkun Eray; Onal, Uğur; Dilektaşlı, Aslı Görek; Sağlık, İmran; Coşkun, Funda; Ediger, Dane; Uzaslan, Esra; AkalIn, Halis; Karadağ, Mehmet; AYDIN GÜÇLÜ, ÖZGE; URSAVAŞ, AHMET; OCAKOĞLU, GÖKHAN; DEMİRDÖĞEN, EZGİ; ACET ÖZTÜRK, NİLÜFER AYLİN; ÖMER TOPÇU, DİLARA; TERZİ, ORKUN ERAY; ÖNAL, UĞUR; GÖREK DİLEKTAŞLI, ASLI; SAĞLIK, İMRAN; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; AkalIn, Halis; KARADAĞ, MEHMET; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0003-1005-3205; 0000-0002-1114-6051; 0000-0002-7400-9089; 0000-0002-6375-1472; 0000-0001-7099-9647; 0000-0002-2954-4293; 0000-0001-7530-1279; 0000-0002-9027-1132; AAH-5180-2021; A-4970-2019; AAG-8744-2021; AAI-3169-2021; JCO-3678-2023; JPK-7012-2023Introduction: In a resource-constrained situation, a clinical risk stratification system can assist in identifying individuals who are at higher risk and should be tested for COVID-19. This study aims to find a predictive scoring model to estimate the COVID-19 diagnosis.Materials and Methods: Patients who applied to the emergency pandemic clinic between April 2020 and March 2021 were enrolled in this retrospective study. At admission, demographic characteristics, symptoms, comorbid diseases, chest computed tomography (CT), and laboratory findings were all recorded. Development and validation datasets were created. The scoring system was performed using the coefficients of the odds ratios obtained from the multivariable logistic regression analysis.Results: Among 1187 patients admitted to the hospital, the median age was 58 years old (22-96), and 52.7% were male. In a multivariable analysis, typical radiological findings (OR= 8.47, CI= 5.48-13.10, p< 0.001) and dyspnea (OR= 2.85, CI= 1.71-4.74, p< 0.001) were found to be the two important risk factors for COVID-19 diagnosis, followed by myalgia (OR= 1.80, CI= 1.082.99, p= 0.023), cough (OR= 1.65, CI= 1.16-2.26, p= 0.006) and fatigue symptoms (OR= 1.57, CI= 1.06-2.30, p= 0.023). In our scoring system, dyspnea was scored as 2 points, cough as 1 point, fatigue as 1 point, myalgia as 1 point, and typical radiological findings were scored as 5 points. This scoring system had a sensitivity of 71% and a specificity of 76.3% for a cut-off value of >2, with a total score of 10 (p< 0.001).Conclusion: The predictive scoring system could accurately predict the diagnosis of COVID-19 infection, which gave clinicians a theoretical basis for devising immediate treatment options. An evaluation of the predictivePublication Utilization of different aspects of digital health among pulmonology residents in Turkey during the pandemic(European Respiratory Soc Journals Ltd, 2022-09-04) Çetin, N.; İnam, M. G.; Terzi, Orkun Eray; Özkul, A.; Teke, N. H.; Parlak, M.; Uğurlu, A. Özsancak; TERZİ, ORKUN ERAY; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; GGZ-0534-2022Publication Stress and workload impact of the COVİD-19 pandemic on pulmonology residents(European Respiratory Soc Journals Ltd, 2022-09-04) İnam, M. G.; Çetin, N.; Terzi, Orkun Eray; Teke, N. H.; Parlak, M.; Özkul, A.; Uğurlu, A. Özsancak; TERZİ, ORKUN ERAY; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; GGZ-0534-2022Publication High-risk obstructive sleep apnea is related to longer hospital stay in covid-19 patients(Kare Publ, 2022-05-01) Alkan, Serap; Dikiş, Özlem Sengören; Salı, Mürsel; Yılmaz, Dilber; Tasbaş, Esin; Cengiz, Arzu Ertem; Bahçetepe, Dilek; Aydın, Asena; Yavuz, Zekiye; Beyeç, Melike; Onal, Başak; Zeytinoğlu, Duygu; ACET ÖZTÜRK, NİLÜFER AYLİN; AYDIN GÜÇLÜ, ÖZGE; GÖREK DİLEKTAŞLI, ASLI; DEMİRDÖĞEN, EZGİ; Güçlü, Özge Aydın; Terzi, Orkun; TERZİ, ORKUN ERAY; COŞKUN, NECMİYE FUNDA; Coskun, Funda; EDİGER, DANE; Ediger, Dane; Uzaslan, Esra; UZASLAN, AYŞE ESRA; Karadağ, Mehmet; URSAVAŞ, AHMET; KARADAĞ, MEHMET; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; AAG-8744-2021; AAD-1271-2019; JPK-7012-2023; AAI-3169-2021; AAE-9142-2019BACKGROUND AND AIM: Obstructive sleep apnea (OSA), having an increased inflammatory state due to an imbalance between sympathetic and parasympathetic activity, intermittent hypoxia, and increased cytokines, may aggravate the immune response for COVID-19 infection. Our aim was to evaluate the effect of OSA upon inflammatory response and length of stay in patients with favorable outcomes.METHODS: Patients admitted to an outpatient clinic after being hospitalized for treatment of COVID-19 were included consecutively in this cross-sectional multicenter observational study. STOP-Bang Questionnaire and a cut-off value of 3 points were used to identify patients with a high risk of OSA.RESULTS: Study population consisted of 201 patients with a median STOP-Bang score of 2.0 (1.0-4.0) points. According to the cut-off value of 3 points, 94 (46.8%) patients were classified as high-risk OSA patients. High-risk OSA patients were older, had many comorbidities such as hypertension, coronary artery disease, and diabetes mellitus, had higher serum D-dimer, ferritin, C-reactive protein, and procalcitonin measurements, and had a longer hospital stay. Possible risk factors associated with length of stay were age, lymphocyte count, and total STOP-Bang score. Multivariable analysis revealed that a 1 point increase in STOP-Bang score results in a 0.43 day longer hospital stay.CONCLUSIONS: Prevalence of OSA within COVID-19 patients with favorable outcomes is similar to the general population. However, the length of stay is related to the presence of high-risk OSA. Our study, therefore, suggests that OSA is related to delayed improvement of COVID-19 infection.Publication Interleukin-21: A potential biomarker for diagnosis and predicting prognosis in covid-19 patients(Tubitak Scientific & Technological Research Council Turkey, 2021-01-01) ACET ÖZTÜRK, NİLÜFER AYLİN; URSAVAŞ, AHMET; GÖREK DİLEKTAŞLI, ASLI; DEMİRDÖĞEN, EZGİ; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; YÖYEN ERMİŞ, DİĞDEM; KARACA, MERT; TERZİ, ORKUN ERAY; BAYRAM, MERVE; ÖMER TOPÇU, DİLARA; Yigitliler, Busra; YURTTAŞ, AHMET; Maharramov, Shahriyar; YAZICI, GAMZE; ORAL, HALUK BARBAROS; KARADAĞ, MEHMET; Tıp Fakültesi; 0000-0002-6375-1472; 0000-0001-7099-9647; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0002-2954-4293; 0000-0001-5871-8769; 0000-0003-0463-6818; 0000-0002-9027-1132; AAG-7406-2021; AAD-1271-2019; AAH-3888-2021; K-7285-2012; AAG-8744-2021; AAI-3169-2021; JPK-7012-2023; AAE-9142-2019Background/aim: COVID-19 patients have a wide spectrum of disease severity. Several biomarkers were evaluated as predictors for progression towards severe disease. IL-21 is a member of common gamma-chain cytokine family and creates some specific effects during programming and maintenance of antiviral immunity. We aimed to assess IL-21 as a biomarker for diagnosis and outcome prediction in patients hospitalized with COVID-19. Materials and methods: Patients with a preliminary diagnosis of COVID-19 and pneumonia other than COVID-19 admitted to a tertiary care hospital were included consecutively in this comparative study. Results: The study population consisted of 51 patients with COVID-19 and 11 patients with non-COVID-19 pneumonia. Serum IL-21 concentration was markedly higher, and serum CRP concentration was significantly lower in COVID-19 patients compared to nonCOVID-19 pneumonia patients. Within COVID-19 patients, 10 patients showed radiological and clinical progression. Patients with clinical worsening had lower lymphocyte count and haemoglobin. In addition to that, deteriorating patients had higher urea, LDH levels, and elevated concentration of both IL-6 and IL-21. The cut-off value of 106 ng/L for IL-21 has 80.0% sensitivity, %60.9 specificity for discriminating patients with clinical worsening. Multivariable analysis performed to define risk factors for disease progression identified IL-6 and IL-21 as independent predictors. Odds ratio for serum IL-6 concentrations >_ 3.2 pg/mL was 8.07 (95% CI: 1.3747.50, p = 0.04) and odds ratio for serum IL-21 concentrations >_ 106 ng/L was 6.24 (95% CI: 1.04 - 37.3, p = 0.02). Conclusion: We identified specific differences in serum IL-21 between COVID-19 and non-COVID-19 pneumonia patients. Serum IL-21 measurement has promising predictive value for disease progression in COVID-19 patients. High serum IL-6 and IL-21 levels obtained upon admission are independent risk factors for clinical worsening.Publication Bağışıklığı baskılanmış hastalarda gelişen pnömonide prognozun ve etiyolojik ajanların değerlendirilmesi(Bursa Uludağ Üniversitesi, 2024-06-13) Öztürk, Nilüfer Aylin Acet; Güçlü, Özge Aydın; Terzi, Orkun Eray; Demirdöğen, Ezgi; Dilektaşlı, Aslı Görek; Kazak, Esra; Ursavaş, Ahmet; Karadağ, Mehmet; ACET ÖZTÜRK, NİLÜFER AYLİN; AYDIN GÜÇLÜ, ÖZGE; TERZİ, ORKUN ERAY; DEMİRDÖĞEN, EZGİ; GÖREK DİLEKTAŞLI, ASLI; KAZAK, ESRA; URSAVAŞ, AHMET; KARADAĞ, MEHMETBağışıklığı baskılanmış hastaların sayısı uygulanan tedavilerinde izlenen gelişimler sonucunda artış göstermekte ve bu olgularda akciğer komplikasyonları önemli morbidite ve mortalite ile sonuçlanmaktadır. Çalışmamızda birincil amacımız COVID-19 pandemisi öncesinde kliniğimizde takip edilen bağışıklığı baskılanmış hastalarda gelişen pnömoni olgularının klinik özellikleri ve prognozla ilişkili faktörlerin değerlendirilmesidir. 1 Ocak 2019 – 31 Aralık 2019 tarihleri arasında pnömoni tanısı ile tetkikleri veya tedavisi düzenlenen immunsuprese olgular retrospektif olarak taranarak çalışmaya dahil edildi. Çalışmaya dahil edilen 104 hastanın ortanca yaşı 59,0 ve %56,7’si erkekti. Hastane-içi mortalite oranı %27,8 ve mortalite ile seyreden grupta kan prokalsitonin düzeyi daha yüksek ve solunum yetmezliği daha sıktı. Çok değişkenli analizlerde ise mortalite ile fungal enfeksiyon belirteçleri yakın ilişkiliydi. Solunum yolu örneklerinde en sık üreyen bakteriyel patojenler sırasıyla; Klebsiella spp, P. aeruginosa ve Acinetobacter spp. idi. Solunum yolu örneklerinde genişletilmiş beta laktamaz direnci %33,3 olarak izlenirken karbepenem direnci %39,3 ve kinolon direnci %38,8 sıklıkla saptandı. Güncel literatür ile karşılaştırıldığında çalışmamızda izlenen mortalite oranı diğer çalışmalar ile benzerlik gösterirken saptanan patojen bakterilerin dağılımı oldukça farklılık göstermektedir. Bu farklılıklar çalışma tasarımlarının farklılığının yanı sıra farklı bölgelerde immunsuprese olguların dağılımının farkından, antibiyotik kullanım politikalarının farklılığından kaynaklanabilmektedir. Çalışmamızın sonuçları bağışıklığı baskılanmış bireylerde toplum kökenli pnömoni ampirik tedavisinin düzenlenmesinde yol gösterici olabilir.