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ÖNDER, CEM

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ÖNDER

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CEM

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    Publication
    Riluzole is effective on spinal decompression for treating acute spinal injury when compared with methylprednisolone and the combination of two drugs: In vivo rat model
    (Sage Publications Ltd, 2023-02-22) Önder, Çiğdem; Önder, Cem; ÖNDER, CEM; Akesen, Selcan; AKESEN, SELCAN; Akesen, Burak; AKESEN, BURAK; Yumusak, Ezgi; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmotoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-7773-3419; HKW-7185-2023
    Study Design Randomized controlled animal experiment. Objectives To determine and compare the efficacy of riluzole, MPS and the combination of two drugs in a rat model with acute spinal trauma, electrophysiologically and histopathologically. Methods 59 rats were divided into 4 groups as control, riluzole (6 mg/kg, every 12 hours for 7 days), MPS (30 mg/kg, 2nd and 4th hours after injury) and riluzole + MPS. Spinal trauma was created and the subjects were followed for 7 days. Electrophysiological recordings were made via neuromonitoring. The subjects were sacrificed and histopathological examination was made. Results For the amplitude values, mean alteration in the period from the spinal cord injury to the end of the 7th day is 15.89 +/- 20.00%, 210.93 +/- 199.44%, 24.75% +/- 10.13% increase and 18.91 +/- 30.01% decrease for the control, riluzole, riluzole + MPS and MPS groups, respectively. Although the riluzole treatment group produced the greatest increase in amplitude, it was observed that no treatment provided a significant improvement compared to the control group, in terms of latency and amplitude. It was observed that there was significantly less cavitation area in the riluzole treatment group compared to the control group (P = .020). (P < .05). Conclusions Electrophysiologically, no treatment was found to provide significant improvement. Histopathologically, it was observed that riluzole provided significant neural tissue protection.
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    Publication
    Outcomes of cable fixation after vancouver type b1 periprosthetic femoral fractures
    (Turkish Assoc Trauma Emergency Surgery, 2023-11-01) Yenigül, Ali Erkan; Ermutlu, Cenk; Önder, Cem; Atıcı, Teoman; Durak, Kemal; YENİGÜL, ALİ ERKAN; ERMUTLU, CENK; ÖNDER, CEM; ATICI, TEOMAN; DURAK, KEMAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.; 0000-0002-3396-3407; 0000-0002-8289-8867; AFH-1678-2022; A-5095-2018; AEQ-5464-2022; JKS-7654-2023; COU-4147-2022
    BACKGROUND: In this study, it was aimed to evaluate the patients who underwent cable plate fixation due to a Vancouver-type B1 periprosthetic femur fracture and their clinical results.METHODS: Vancouver-type B1 patients who were operated on for periprosthetic fractures between 2014 and 2019 were investigated. Age, gender, body mass index (BMI), follow-up time, operation time, bleeding amount, non-union fracture, last surgery before fracture, the time between previous surgery and fracture, implant survival, patient survival, and complications were recorded. In addition, the postoperative clinical functions of these patients were compared. RESULTS: 23 patients who met the study criteria (Vancouver type B1 fracture) were identified. The mean age of the patients was 60 (49-76) years, the mean BMI was 26.3 (17.5-40.7), and the postoperative mean follow-up period was 14 (6-36) months. Considering the gender distribution, there were 5 (22%) men and 18 (78%) women. The mean time between the last surgery before the fracture and the fracture was 6 months (0-30). While the mean operation time was 95 min (60-180), the average amount of bleeding was 310 mL (150-600). Functional evaluations of patients: In total, five patients had decreased ambulatory abilities after surgery. Nonunion was observed in 2 patients during the follow-ups, and these patients underwent open surgery for treatment.CONCLUSION: Cable and locking plate applications are successful in Vancouver type B1 fractures, which are one of the most common forms of periprosthetic fractures. In this technique, the duration of the operation can be shortened under ideal conditions, and the need for blood and blood products is reduced as blood loss is reduced. If there is a complication, you still have the chance to treat it with the option of revision arthroplasty.