Person: EDİGER, DANE
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EDİGER
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DANE
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Publication Venom allergy in Turkish beekeepers and risk factors for systemic reaction(Wiley, 2015-09-01) Ediger, Dane; Terzioğlu, Kadriye; Öztürk, Tülümen Raziye; EDİGER, DANE; Terzioğlu, Kadriye; TÜLÜMEN ÖZTÜRK, RAZİYE; Tıp Fakültesi; 0000-0002-2954-4293; AAE-9142-2019; CGN-8618-2022; JLI-9749-2023Publication Hypersensitivity reaction due to oral methylprednisolone in a patient with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease(Bilimsel Tip Yayinevi, 2019-01-01) Terzioğlu, Kadriye; Öztürk, Raziye Tulumen; TÜLÜMEN ÖZTÜRK, RAZİYE; Durmus, Eda; Ediger, Dane; EDİGER, DANE; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0001-9503-661X; 0000-0002-2954-4293; AAE-9142-2019Hypersensitivity reactions caused by corticosteroids are rarely seen, despite widespread use of these medications. Sensitization to corticosteroids can occur through many routes such as nasal, aerosol, parenteral, oral and topical. Delayed allergic reactions may be observed after topically applied glucocorticoids, but IgE-mediated type 1 (immediate) allergic reactions, which occur after systemic application of glucocorticoids, are very rare. When case-based publications were examined, it was noticed that corticosteroid-associated IgE-mediated type 1 hypersensitivity reactions were more common in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory diseases (NERD). We present a 32-year-old patient with nonsteroidal anti-inflammatory drug-exacerbated airway disease and a hypersensitivity reaction due to methylprednisolone.Publication The importance of gender factor in evaluation of spirometric and nutritional parameters in patients with stable COPD(Kare Yayınevi, 2009-12-01) Göçmen, Hayrettin; Ediger, Dane; Uzaslan, Esra; Ertem, Arzu; Ege, Ercüment; Göçmen, Hayrettin; EDİGER, DANE; UZASLAN, AYŞE ESRA; Ertem, Arzu; Ege, Ercüment; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0002-2954-4293; AAI-1004-2021; AAE-9142-2019; JLE-1834-2023; CNR-8456-2022; CPF-5844-2022Aim: We aimed to evaluate the relationship between sex factor, spirometric and nutritional parameters in patients with stable COPD.Material and methods: Patients with stable COPD who had no additional problem that affects spirometric and nutritional results, were included in the study. By the application of SGRQ questionnarie nutritional parameters, spirometric and demographic findings of cases were recorded and evaluated.Results: Totally 100 patients with stable COPD (81 males, 19 females and mean age 65.1 +/- 4.3 years) were evaluated prospectively. % FEV1 (p=0.003), % FEF25-75 (p=0.011), % PEF (p=0.003) values and smoking package-years (p=0.009) were found significantly higher in males. Body Mass Index values were significantly higher (p=0.018) in females (30.7 +/- 6.6) than males (27.4 +/- 4.9). In males higher triceps skin thickness values (p<0.001) and lower SGRQ scores (p=0.036) were found.Conclusion: Smoking is the most important agent in devoloping of COPD. Although smoking duration was shorter in females spirometric findings were worse. In spite of this finding, because of better nutritional parameters and lower SGRQ scores, it is thought that there is insensitivity in females to systemic response.Publication How physicians approach hereditary angioedema: A single center study(Lippincott Williams & Wilkins, 2022-10-01) Terzioğlu, Kadriye; Ediger, Dane; Özdemir, Ebru; Tulumen Öztürk, Raziye; Doğan, Fatma Oflu; Sancar, Özgür; Terzioğlu, Kadriye; EDİGER, DANE; Özdemir, Ebru; TÜLÜMEN ÖZTÜRK, RAZİYE; Doğan, Fatma Oflu; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; İmmünoloji ve Alerji Hastalıkları Bilim Dalı; CGN-8618-2022; AAE-9142-2019; HGF-0700-2022; GDN-2707-2022; IBV-5646-2023Background: Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by C1-inhibitor deficiency. It is characterized by recurrent attacks of cutaneous and upper respiratory tract swelling, and abdominal pain due to mucosal edema. Early detection and treatment prevent unnecessary interventions, improves quality of life, and prevents potentially fatal attacks. Objective: The present study aims to investigate physicians level of knowledge and awareness regarding HAE. Methods: A questionnaire about HAE was applied to 393 physicians from a university hospital. Participants were requested to choose one or several answers to multiple-choice questions. Results: Seven and three tenths percent of study participants stated to have never heard of HAE. Twenty-seven physicians (7.4%) chose the exact correct answers regarding diagnostic tests, and 2 (0.8%) chose the exact correct answers regarding emergency management. A composite of internists, pediatrists and emergency medicine specialists had a significantly higher mean score than other physicians ( p = 0.047). Physicians from internal medical sciences scored significantly higher than physicians from surgical medical sciences ( p = 0.022). Conclusion: The present study reveals that physician awareness about HAE is low, and physicians misdiagnose HAE attacks as histaminergic angioedema attacks, and therefore provide ineffective treatment. Although HAE is a rare disease, physician awareness must be increased, because early diagnosis and effective treatment are vital for the patients.Publication Impact of childhood diseases and familial asthma history on adult asthma characteristics: Results from turkish adult asthma registry (TAAR)(Wiley, 2023-12-01) Demir, S.; Dursun, A. B.; Öztürk, A. B.; Gökmen, D.; Cengiz, A.; Barış, S. Argün; Arslan, B.; Ediger, Dane; Kara, B. Y.; Çelik, G.; Taar, S. G.; EDİGER, DANE; Uludağ Üniversitesi; AAE-9142-2019Publication Familial cases with hereditary angioedema type I (8 cases)(Wiley, 2015-09-01) Ediger, Dane; Özdemir, E.; Kadriye, T.; EDİGER, DANE; Özdemir, Evren; Kadriye, T.; Tıp Fakültesi; Alerji Bölümü; 0000-0002-2954-4293; 0000-0001-8131-9133; AAE-9142-2019; DMN-2740-2022; FDK-8467-2022Publication Impact of covid-19 pneumonia on pulmonary function, functional exercise capacity and quality of life(European Respiratory Soc Journals, 2021-09-05) Dilektasli, Asli Gorek; GÖREK DİLEKTAŞLI, ASLI; Ozturk, Nilufer; ACET ÖZTÜRK, NİLÜFER AYLİN; Odabas, Ayten; Demirdogen, Ezgi; DEMİRDÖĞEN, EZGİ; Ursavas, Ahmet; URSAVAŞ, AHMET; Coskun, Funda; COŞKUN, NECMİYE FUNDA; Guclu, Ozge Aydin; AYDIN GÜÇLÜ, ÖZGE; Ediger, Dane; EDİGER, DANE; Uzaslan, Esra; UZASLAN, AYŞE ESRA; Tıp Fakültesi; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0003-1005-3205; 0000-0002-2954-4293; AAI-3169-2021; AAE-9142-2019; JPK-7012-2023; AAD-1271-2019Publication Evaluation of fibrinogen levels in patients with obstructive sleep apnea syndrome(Wiley, 2013-11-01) Çetinoğlu, Ezgi Demirdoğen; Ursavaş, Ahmet; Karadağ, Mehmet; Coşkun, Funda; Ediger, Dane; Uzaslan, Esra; Ege, Ercüment; Gözü, Oktay; Çetinoğlu, Ezgi Demirdoğen; URSAVAŞ, AHMET; KARADAĞ, MEHMET; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; Ege, Ercüment; Gözü, Oktay; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0002-7400-9089; 0000-0002-9027-1132; 0000-0003-3604-8826; 0000-0002-2954-4293; AAI-3169-2021; AAD-1271-2019; AAG-8744-2021; JPK-7012-2023; AAE-9142-2019; AAH-9812-2021; CDI-1977-2022; CPF-5844-2022; JLC-5863-2023Publication Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in adults: Beyond current classification(Codon Publications, 2023-01-01) Cerci, Pamir; Kendirlinan, Reşat; Büyüköztürk, Suna; Gelincik, Aslı; Ünal, Derya; Demir, Semra; Erkekol, Ferda Öner; Karakaya, Gül; Dursun, Adile Berna; Çelikel, Serhat; Ediger, Dane; Abadoglu, Öznur; Bavbek, Sevim; EDİGER, DANE; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; Alerji ve İmmünoloji Ana Bilim Dalı; AAE-9142-2019Background: Hypersensitivity reactions (HSRs) to nonsteroidal anti-inflammatory drugs (NSAIDs) are a significant clinical issue. Several classifications have been proposed to categorize these reactions, including the current European Academy of Allergy and Clinical Immunology/ European Network for Drug Allergy (EAACI/ENDA) classification. This study aimed to evaluate the applicability of this classification in a real-world clinical setting.Methods: We conducted a national multicenter study involving patients from nine hospitals in four major urban centers in Turkey. All patients had a suggestive clinical history of hypersensitivity reactions to NSAIDs. Researchers collected data using a structured form and classified reactions based on the EAACI/ENDA classification. Oral provocation tests with several NSAIDs were performed using a single-blind challenge per EAACI/ENDA guidelines.Results: Our retrospective study included 966 adult patients with a history of hypersensitivity to NSAIDs. The most common triggers were Acetylsalicylic Acid (ASA), paracetamol, and metamizole. The most prevalent acute NSAID hypersensitivity group was NSAID-induced urticaria/ angioedema (NIUA) (34.3%). However, 17.3% of patients did not fit neatly into the current EAACI/ENDA classification. Notably, patients with underlying asthma or allergic rhinoconjunctivitis exhibited unusual reactions, such as urticaria and/or angioedema induced by multiple chemical groups of NSAIDs, blended mixed reactions, and isolated periorbital angioedema in response to multiple chemical groups of NSAIDs.Conclusions: While the EAACI/ENDA classification system stratifies NSAID-induced hypersensitivity reactions into five distinct endotypes or phenotypes, it may not fully capture the diversity of these reactions. Our findings suggest a need for further research to refine this classification system and better accommodate patients with atypical presentations.Publication Il-21: A potential biomarker for diagnosis and predicting prognosis in covid-19 patients(European Respiratory Society Journals, 2021-09-05) Öztürk, Nilüfer Aylin Acet; Ursavaş, Ahmet; Dilektaşlı, Aslı Görek; Demirdöğen, Ezgi; Coşkun, Funda; Ediger, Dane; Uzaslan, Esra; Yöyen-Ermiş, Diğdem; Karaca, Mert; Terzi, Orkun; Bayram, Merve; Ömer, Dilara; Yiğitliler, Büşra; Yurttaş, Ahmet; Maharramov, Shahriyar; Çelik, Gamze; Oral, Barbaros; Karadağ, Mehmet; ACET ÖZTÜRK, NİLÜFER AYLİN; URSAVAŞ, AHMET; GÖREK DİLEKTAŞLI, ASLI; DEMİRDÖĞEN, EZGİ; COŞKUN, NECMİYE FUNDA; EDİGER, DANE; UZASLAN, AYŞE ESRA; YÖYEN ERMİŞ, DİĞDEM; KARACA, MERT; TERZİ, ORKUN ERAY; BAYRAM, MERVE; ÖMER TOPÇU, DİLARA; YURTTAŞ, AHMET; ORAL, HALUK BARBAROS; KARADAĞ, MEHMET; MAHARRAMOV, SHAHRİYAR; YAZICI, GAMZE; Tıp Fakültesi; 0000-0002-6375-1472; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0002-2954-4293; 0000-0001-5871-8769; 0000-0002-9027-1132; AAG-8744-2021; JPK-7012-2023; AAH-3888-2021; AAE-9142-2019; AAI-3169-2021; AAD-1271-2019