Person: ŞENLİK, BAYRAM
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ŞENLİK
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BAYRAM
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Publication Association between ovine toll-like receptor 4 (TLR4) gene coding variants and presence of eimeria spp. in naturally infected adult Turkish native sheep(Taylor, 2020-09-23) Yaman, Yalçın; Aymaz, Ramazan; Keles, Murat; Bay, Veysel; Özuiçli, Mehmet; Şenlik, Bayram; ÖZÜİÇLİ, MEHMET; ŞENLİK, BAYRAM; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı; JIF-7199-2023; GBN-0139-2022Coccidiosis caused byEimeriaspp. is a protozoan disease prevalent in farm animals, and it is responsible for serious economic losses especially in young animals. It has been popular to breed disease-resistant animals due to the concern about food safety, animal welfare, and public health. Toll-like receptor (TLR) gene family plays a key role in the innate immune system participating in host-antigen interaction, therefore, they are candidate genes for breeding disease-resistant animals. In the present study, possible genetic associations betweenTLR4gene coding variants and the presence ofEimeriaspp. in adult Turkish sheep were investigated. For this purpose, the presence ofEimeriaspp. in fecal samples from six native Turkish sheep were determined, and approximately 1450 bp region in the 3rd exon of the ovineTLR4gene was sequenced. Ten nonsynonymous and four synonymous single nucleotide polymorphisms (SNPs) were detected in the targeted region. Statistical analyses revealed that the SNP at the codon at 356(th)position encoding Leucine instead of Phenylalanine (F356L) was significantly associated with the presence ofEimeriaspp. It was found that the individuals carrying at least one Leucine amino acid sequence at this position have 2.3-fold more risk for the presence ofEimeriaspp.Publication Detecting fecal egg count (FEC) for gastrointestinal nematodes of adult Turkish sheep with different scrapie related PRNP haplotypes(Taylor & Francis, 2020-12-10) Yaman, Yalçın; Şenlik, Bayram; Özuiçli, Mehmet; Keleş, Murat; Aymaz, Ramazan; Bay, Veysel; Hatipoğlu, Ecem; Koncagül, Seyrani; Öner, Yasemin; Ün, Cemal; ŞENLİK, BAYRAM; ÖZÜİÇLİ, MEHMET; ÖNER, YASEMİN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Biyometri ve Genetik Bölümü.; GBN-0139-2022 ; JIF-7199-2023 ; ABB-3181-2020Scrapie is a transmissible spongiform encephalopathy caused by prions and leads to neurodegeneration in the Central Nervous System (CNS) of sheep and goats. Genetic resistance/susceptibility to scrapie is well studied and it is known that the variations of 136th, 154th and 171st codons at the ovine PRNP gene have a major effect on the development of the disease. Many studies demonstrated that selection for PRNP genotypes has not influenced other performance traits, nevertheless, there is a knowledge gap about the possible link between the PRNP gene and the status of the other important diseases that affect the sheep population worldwide. In the present study, we tested whether there is an association between scrapie-related PRNP genotypes and fecal egg count (FEC) of gastrointestinal nematodes in seven adult Turkish sheep breeds. For this purpose, FEC scores of studied sheep (n = 253) were determined and the same animals were genotyped for the PRNP gene. Finally, an association analysis was performed for scrapie resistant (ARR), susceptible (VRQ), and wild-type (ARQ) haplotypes. Based on our statistical analysis, it is concluded that PRNP genotypes have no positive or negative effect on the FEC scores of adult sheep.Publication Response to doxycycline and oxytetracycline treatments in cats infected with Mycoplasma spp. and analysis of haemato-clinical findings and risk factors(Malaysian Soc Parasitology Tropical Medicine, 2021-06-01) Çetin, H. S.; Ekici, O.; Küçükyıldız, F.; Şenlik, B.; ŞENLİK, BAYRAM; Bursa Uludağ Üniversitesi/Veterinerlik Fakültesi.; 0000-0003-2964-2245; AAD-1304-2021This study was planned to determine the efficacy of doxycycline and oxytetracycline in the treatment of feline Mycoplasma spp. infections and to analyze risk factors as well as clinical and haematological findings. Cats accepted to the clinic with complaints such as weakness, loss of appetite and fever were routinely examined. Clinical history of animal was demanded from the owner. An interview and a short questionnaire were conducted to owner to evaluate the risk factors associated with possible Mycoplasma status of animal. During the interview, the age, sex, breed, housing, flea infestation, worm control, external parasite control, other accompanying infections and vaccination status of cats were asked and the data recorded. Peripheral blood smears were stained with the DIFF-QUICK. Fifty positive cats were included in the study, 16 of which were treated with doxycycline (orally, 5 mg/kg twice a day) while other 34 with oxytetracycline (intramuscular injection, 10 mg/kg once a day). It was determined that all (100%) cats with Mycoplasma spp. infection had a flea infestation. Majority of cats (94%) did not receive the regular antiparasitic application and only 6 (12%) of them had complete vaccinations. Mycoplasma spp. infection was associated with younger age and outdoor access. Among the feline breed, striped cat (74%) was more prone to infection. The most common clinical signs encountered in cats were weakness (94%) and anorexia (84%). Haematological parameters revealed thrombocytopenia (86%), and anaemia (40%) in infected cats. At the end of the treatment, recovery rates for doxycycline and oxytetracycline groups were 87.5% and 67.6%, respectively. General status of these cats indicated significant improvement on the 4th day of treatment, and clinical symptoms are restored on the 7th day. Mycoplasmosis is an important infection for cats having anaemia, thrombocytopenia and leukocytosis. Flea infestations are risk factor for contamination of the disease. Based on our results, we recommend doxycycline treatment (5 mg/kg) for up to 21 days for elimination of Mycoplasma spp. in the blood of infected cats.Publication Long term investigations on tick infestations of human(Kafkas Üniversitesi Veteriner Fakultesi Dergisi, 2015-11-01) Selçuk, Özgür; Aydın, Levent; Girişgin, Ahmet Onur; Şenlik, Bayram; Özakin, Cüneyt; Selçuk, Özgür; AYDIN, LEVENT; GİRİŞGİN, AHMET ONUR; ŞENLİK, BAYRAM; ÖZAKIN, CÜNEYT; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobioloji Bölümü; Uludağ Üniversitesi/Veteriner Fakültesi/Parasitoloji Bölümü; 0000-0002-0020-2708; 0000-0003-2964-2245; AAG-8392-2021; B-5286-2017; JLA-7878-2023; HLG-4450-2023; GBN-0139-2022In this study, a total of 19866 samples which were collected from humans who applied to the hospitals with tick bites in the western part of Turkey (Bursa) between the years 2007 and 2011 (from February to November) were examined. Approximately 10% (1985) of samples were found as non-ticks like bee stings, lice, fleas and other arthropods. The ticks were identified as Rhipicephalus spp. (72.98%), Ixodes spp. (18.96%), Hyalomma spp. (7.18%), Dermacentor marginatus (0.027%) and Haemaphysalis parva (0.005%). Based on localities, majority of the tick samples were reported from the urbanized areas (81%). Especially, Ixodes spp. species were commonly found in highland and forestry areas of Bursa.Publication Determination of diagnostic value of cELISA for the diagnosis of anaplasmosis in clinically suspected ruminants(Kafkas Üniversitesi, 2015-09-01) Selçuk, Özgür; Alver, Oktay; Çatık, Serkan; Aydın, Levent; Şenlik, Bayram; Selçuk, Özgür; ALVER, OKTAY; Çatık, Serkan; AYDIN, LEVENT; ŞENLİK, BAYRAM; Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0003-2964-2245; AAA-5241-2021; JLA-7878-2023; JLJ-9087-2023; HLG-4450-2023; GBN-0139-2022The aim of this study was to determine diagnostic value of cELISA in anaplasmosis in clinically suspected animals and to compare the cELISA results with the clinical examination results. For this purpose a total of 720 ruminants (457 cattle, 146 sheep, 117 goat) were examined in terms of clinical signs. Eighty-eight ruminants consisting of 61 cattle, 11 sheep and 16 goat which had the symptoms of anemia, fever, icterus, weakness, depression and lack of appetite were selected for the study. Blood samples were collected from the jugular vein of all clinically suspected animals and serum samples were separated. A commercially available competitive enzyme-linked immunosorbent assay (C-ELISA) kit was used for determine antibodies to Anaplasma species. cELISA based diagnosis revealed that 47 of 88 serum samples (53.4%) were positive for anaplasmosis. In serological examination Anaplasma specific antibodies were determined in 45.9% of cattle, 63.6% of sheep and 56.2% of goats. Seropositivity rate was statistically differ among the age groups of cattle and the highest seropositvity rate was found in <12 month age (P < 0.005). However no difference was found in the seropositivity rate of Anaplasma in sheep and goat in relation to age group. From the data obtained in this study it can be concluded that clinical findings are not sufficient criteria for the diagnosis of anaplasmosis and must be supported by serological examination.Publication Helminths of the digestive tract in buteo buteo (Falconiformes: Falconidae) in Bursa province of northwest Turkey(Tübitak Bilimsel ve Teknolojik Araştırma Kurumu, 2015-01-01) Tezel, Mehmet; Girişgin, Ahmet Onur; Birlik, Sezen; Yıldırımhan, Hikmet Sami; Şenlik, Bayram; Tezel, Mehmet; GİRİŞGİN, AHMET ONUR; BİRLİK, SEZEN; YILDIRIMHAN, HİKMET SAMİ; ŞENLİK, BAYRAM; Uludağ Üniversitesi/Veteriner Fakültesi/Parasitoloji Bölümü; 0000-0002-0020-2708; 0000-0003-2964-2245; AAB-9963-2020; B-5286-2017; AAC-1581-2020; CDI-4443-2022; GBN-0139-2022Raptors can be parasitized by numerous helminth species due to their feeding behavior. When the parasite load is high, the bird's life can be affected. A total of 21 common buzzards, Buteo buteo, from different districts of Bursa, in Northwest Turkey, were examined for helminth infections. The results of the postmortem examination revealed that 15 of 21 buzzards (71.43%) harbored 1 or more helminth species. Seven species/genera of helminths were detected at the following prevalence rates: ascarid larvae (47.62%), Strigea falconis (38.09%), Neodiplostomum attenuatum (33.33%), Cladotaenia globifera (14.29%), Centrorhynchus amphibius (14.29%), Physaloptera alata (9.52%), and Synhimantus laticeps (4.76%). The most common helminth species was S. falconis, which was found in the small intestine of its hosts. This study is the first report to describe the presence of N. attenuatum, S. falconis, C. globifera, P. alata, and C. amphibius in the common buzzards of Turkey. This study is also the first to report the presence of S. laticeps in common buzzards, although this helminth had been previously reported in a sparrow hawk in Turkey.Publication Ectoparasites of hedgehogs (Erinaceus concolor) from Turkey(Schluetersche Verlagsgesellschaft Mbh & Co Kg, 2015-07-01) Girişgin, Ahmet Onur; Şenlik, Bayram; Aydın, Levent; Çırak, Veil Yılgör; GİRİŞGİN, AHMET ONUR; ŞENLİK, BAYRAM; AYDIN, LEVENT; ÇIRAK, VELİ YILGÖR; Uludağ Üniversitesi/Veteriner Fakültesi/Parasitoloji Bölümü; 0000-0002-0020-2708; 0000-0003-2964-2245; B-5286-2017; GBN-0139-2022; HLG-4450-2023; CKL-2130-2022Hedgehogs are small, nocturnal, spiny-coated animals that have been growing in popularity as exotic pets. However, these animals are host to a wide variety of viruses, bacteria, fungi and parasites, some of which are of zoonotic character. Thus, because hedgehogs have a potential role to transmit zoonoses including arthropod-borne diseases, we examined them for their ectoparasites. The study was carried out on hedgehogs found dead mainly due to road casualties in the Bursa province of Turkey. The ectoparasites were collected by both insecticide spraying of the body and inspection on a white paper carefully. Totally three species of ticks (Rhipicephalus sanguineus, Hyalomma aegyptium, Haemaphysalis parva) and one flea species (Archeopsylla erinacei) were detected. The prevalence of mixed infestation with both ticks and fleas was 45.5%. Haemaphysalis parva was reported for the first time from hedgehogs (Erinaceus concolor) in Turkey. The occurrence of ectoparasites and their potential role as vectors of certain zoonotic diseases are briefly discussed.Publication Trichostrongylosis in cattle from south Marmara Region of Turkey: Assessment of various factors related to faecal egg counts(Kafkas Univ, Veteriner Fakultesi Dergisi, 2010-01-01) Tınar, Recep; ŞENLİK, BAYRAM; ÇIRAK, VELİ YILGÖR; AKYOL, ÇETİN VOLKAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Parasitemoloji Anabilim Dalı.; 0000-0003-2964-2245; 0000-0003-0570-2514A cross-sectional study was carried out to determine faecal egg density in trichostrongyle infections in relation to animal age, animal breed, management system and farm type in cattle in South Marmara region of Turkey. Rectal faecal samples were collected from 513 cattle and coprological examination were conducted by a modified McMaster technique to determine faecal egg counts (FEC) per gram of faeces. Overall egg density was 81.4 +/- 6.8 EPG and it remained generally low. The mean faecal egg counts for adults was higher than those for the youngs. However, no statistically significant difference was found between the age groups for faecal egg counts. Although mean FEC were higher in Turkish Grey than in Holstein and Karacabey Bown, no statistically significant difference could be determined among the animal breeds. Management system was the factor that influenced number of trichostrongyle eggs and animals under semi-extensive system had more egg counts than those kept under intensive management system. Animals in the governmental farm have been found less affected with significant difference than their counterparts at small scale private farms.Publication Exploring the anthelmintic activity of Olea europaea L (Olive) leaves extract and oleuropein in mice naturally infected with Aspiculuris tetraptera(Sciendo, 2023-09-01) Kamran, Muhammad Adeel; YIldIrımhan, Hikmet Sami; Şenlik, Bayram; Kamran, Muhammad Adeel; YILDIRIMHAN, HİKMET SAMİ; ŞENLİK, BAYRAM; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü; Uludağ Üniversitesi/Veteriner Bilimleri Fakültesi/Parazitoloji Anabilim Dalı; 0000-0003-2964-2245; AFN-9439-2022; AAC-1581-2020; GBN-0139-2022Oxyuriasis, caused by the nematode Enterobius vermicularis, is one of the cosmopolitan intestinal infections of humans. Aspiculuris tetraptera commonly infects mice and it is morphologically similar to E. vermicularis. Parasitic resistance reduces the efficiency of synthetic drugs and poses economic impacts on the dairy sector, thus necessitating novel anthelmintic agents. Olea europaea L. (Olive) is a bioactive plant with potent pharmacological activities. However, its effects on oxyurids are poorly known, and no studies are currently exploring olives' anthelmintic potential. In this study, we investigated the pharmacokinetic behaviors of O. europaea leaves extract (OLE) and its phenolic compound oleuropein in mice infected with A. tetraptera, in comparison with Albendazole (ABZ), a standard drug used to treat parasitic worms. Fecal flotation method was used to identify the infestation with A. tetraptera eggs by examining the stool samples from mice. Infected animals were divided into 7 groups. 250 mg/kg, 500 mg/kg, and 1000 mg/kg doses of OLE, 5 mg/kg and 20 mg/kg doses of oleuropein, 10 mg/kg of ABZ and tap water were orally administered by gavage for 7 days during treatments. Drug efficacies and statistical differences between the treatments and controls were evaluated. Our results revealed 92.43 % efficacy of ABZ, similar to 92.19 % efficacy of 1000 mg/kg of OLE. At the same time, 250 mg/kg and 500 mg/kg concentrations of OLE remained 70.03 % and 63.18 % effective in reducing worm counts. Efficacy percentages of 5 mg/kg and 20 mg/kg of oleuropein were 9.27 % and 70.56 %, respectively. Statistical analysis of ABZ was significant compared to 1000 mg/kg of OLE, which was almost equal but insignificant. In general, our results confirm the anthelmintic potential of OLE and oleuropein against mice pinworms and open the way for targeted extraction of bioactive compounds from plants to optimize its use in human and veterinary medicine.