Person: İLHAN, TUNCAY
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İLHAN
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TUNCAY
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Publication The effect of rat adipose-derived stem cells in bone tissue regeneration(Kafkas Univ, Veteriner Fakultesi Dergisi, 2022-04-05) İlhan, Tuncay; İLHAN, TUNCAY; SALCI, HAKAN; Akkoç, Cansel G. Özgüden; Çetin, Melike; Incebıyık, Ece; Canatan, Uygur; CANATAN, UYGUR; Salcı, Hakan; ERDOST, HATİCE; Erdost, Hatice; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı; 0000-0003-0712-0892; JDC-5958-2023; F-2822-2017Stem cell approaches has been increasing in the conventional medicine. This study was planned to determinate the efficacy of adipose-derived stem cells (ADSCs) on the bone fracture's regeneration by histologically, morphologically and radiologically. Primarily isolated cells were cultivated and identified for the obtaining of the third passage mesenchymal stem cells in the cell culture laboratory. The right tibias (applicated ADSCs) were planned as experimental group and the left tibias were studied as control on the clinically healthy 10 rats. The middle diaphysis of the right and left tibias was transversally cut by a thin saw and then fixed by intramedullary pin. Before surgical closure of the incised area, 106 ADSCs were injected on an absorbent material, which covered the cut site of the right tibia, in experimental group. At postoperative 45th day, cranio-caudal and lateral radiographs of the tibias pointed out that there was callus formation in the caudal and lateral parts of the right tibia. After sacrification of the animals, preparations were made for histological examinations. The results indicate that there were clear differences in the mitotic activity; and also, the experimental tibias were found to be rich in blood vessel network. As a conclusion, it was found that ADSCs can have a positive potential effect on osteogenesis in bone tissue.Publication Can thoracic sympathetic nerve damage be reversed?(Georg Thieme Verlag, 2015-12-01) Erol, M. Muharrem; Salcı, Hakan; Melek, Hüseyin; İlhan, Tuncay; Özfiliz, Nesrin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Erol, M. Muharrem; SALCI, HAKAN; MELEK, HÜSEYİN; İLHAN, TUNCAY; ÖZFİLİZ, NESRİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji Anabilim Dalı.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAI-5039-2021; AAE-1069-2022; AAH-2756-2021; JCE-0097-2023; AAH-8859-2021; ABB-7580-2020; T-4623-2019; KHE-8874-2024Background Function of the thoracic sympathetic chain (TSC) reportedly recovers after surgical clips are removed. Hence, this study was designed to study nerve regeneration after unclipping the TSC.Methods The bilateral TSCs of six goats were studied; the goats were separated into three groups (groups I, II, and III) during excision, clipping, and unclipping. During surgery, the TSCs were excised with a scalpel in group I and clipped in groups II and III. In group III, the clips were removed 1 month postoperatively and observed for possible nerve healing for 1 month. All TSCs were examined histologically following en block resection at 1 month postoperatively in groups I and II and at 2 months postoperatively in group III.Results Inflammation in nerve sections was noted following clip removal. Furthermore, there was significant degeneration and cell infiltration in the nerve fibers of the clipped regions. The Schwann cells around the peripheral nerve endings in the unclipped regions facilitated nerve transmission by reconstitution of myelin.Conclusion Clipping the TSC can cause histologic degeneration; however, histologic nerve regeneration occurs after unclipping.