Person: KOCATÜRK, MERİÇ
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
KOCATÜRK
First Name
MERİÇ
Name
16 results
Search Results
Now showing 1 - 10 of 16
Publication Clinical approach to etiology, diagnosis, and treatment in dogs with pericardial effusion - a retrospective study(Ankara Üniversitesi, 2016-01-01) Kocatürk, Meriç; Salcı, Hakan; İpek, Volkan; Çelimli, Nureddin; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YILMAZ, ZEKİ; SALCI, HAKAN; İpek, Volkan; Çelimli, Nureddin; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0002-2849-1222; 0000-0001-5874-7797; 0000-0001-9836-0749; A-9637-2008; ABZ-7197-2022; V-5578-2017; T-4623-2019; JIX-0056-2023In this study, signalement, presenting clinical signs, results of diagnostic investigations and therapeutic outcomes of 17 dogs with pericardial effusion (PE) were evaluated retrospectively. Common findings were exercise intolerance (70%), muffled heart sound (60%) and ascites (50%). ECG showed low voltage QRS (60%) and supraventricular tachycardia (40%). Radiological findings revealed enlarged and globoid cardiac silhouette in all dogs. PE was confirmed by echocardiographic examinations, which was due to intracardiac neoplasia (n=6) or non-neoplastic causes [dilated cardiomyopathy (n=5), right-sided heart failure (RSHF, n=2), and idiopathic (n=4)]. In dogs with RSHF, Doppler-derived pulmonary hypertension was also observed. Analysis of pericardial fluids that was collected by pericardiocentesis showed a hemorrhagic effusion in dogs with intracardiac neoplasia, and transudate in the rest. In 4 dogs with neoplastic PE, pericardiectomy and tumor resection were performed. Histopathological examinations revealed an aortic body adenoma (n=1), aortic body carcinoma (n=1), papillary mesothelioma (n=1) and malignant epitheloid mesothelioma (n=1). In 2 dogs, neoplastic PE could not be classified. Dogs were treated medically for heart failure and neoplasia, as well. Prognosis was better for the first 12 months in dogs with non-neoplastic PE. In conclusion, echocardiographic examination is the best means to diagnose PE. In practice, when added to physically examination findings echocardiography also provides solid information in determining prognosis of PE due to neoplasia versus non-neoplastic causes. Survival time may be extended by pericardiectomy in the case of neoplastic PE, as well.Publication Echocardiographic diagnosis and surgical correction of aortopulmonary window in a Belgian Shepherd Dog (Malinois)(Ankara Üniversitesi, 2015-01-01) Kocaturk-Ocal, Meric; Salcı, Hakan; Çetin, Melike; Karapınar, Tolga; Yılmaz, Zeki; KOCATÜRK, MERİÇ; SALCI, HAKAN; Çetin, Melike; YILMAZ, ZEKİ; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; 0000-0002-2849-1222; 0000-0001-9836-0749; A-9637-2008; V-5578-2017; T-4623-2019; AAB-1790-2022A 20-month-old, female Belgian Malinois Dog was referred for evaluation on exercise intolerance. A high-grade machinery murmur, tachycardia, and cardiomegaly were observed. An aortopulmonary window was diagnosed by a color-Doppler echocardiography showing a turbulent blood flow shunting from the proximal part of ascendance aorta to the main pulmonary artery. This cardiac anomaly was corrected by surgery. Dog was treated by furosemide, pimobendan, and enalapril during post-operative 7 days. 1-year after the surgery, life quality of the patient was perfectly good. This is the first report of this rare congenital heart disease and its successful outcome of surgically correction in Belgian Malinois Dogs.Publication Diagnosis of multiple congenital cardiac defects in a newborn calf(Kafkas Üniversitesi, 2019-11-01) Kocatürk, Meriç; Yazıcıoğlu, Volkan; Salcı, Hakan; Baydar, Ersoy; Yılmaz, Zeki; KOCATÜRK, MERİÇ; Yazıcıoğlu, Volkan; SALCI, HAKAN; YILMAZ, ZEKİ; Veteriner Fakültesi; Kalp Damar Cerrahisi Ana Bilim Dalı; Dahiliye Ana Bilim Dalı; 0000-0001-9836-0749 ; V-5578-2017; GKF-0959-2022; T-4623-2019; A-9637-2008This case report presents the clinical diagnostic work-up and surgical approach via cardiopulmonary by-pass technique in 15 day-old, male, Simmental calf with multiple cardiac defects. Calf suffered from respiratory stress and poor growth. Cardiac auscultation revealed a loud pansystolic murmur with cardiac trill of both transthoracic area of the heart. Cardiomegaly and pulmonary artery bulge (x-ray) and atrial fibrillation were observed. Color Doppler transthoracic echocardiography revealed musculomembranous ventricular septal defect (VSD), atrial septal defect (ASD) and patent ductus arteriosus (PDA) with left to right shunt. Routine hematological and serum biochemistry profiles were non-specific. Calf underwent to lateral thoracotomy for surgical correction of multiple cardiac defects. During the cardiopulmonary by-pass, calf was dead due to hemodynamic imbalances and ventricular fibrillation. Necropsy confirmed the presence of multiple cardiac defects in this case.Publication Plasma chymase activity reflects the change in hemodynamics observed after the surgical treatment of patent ductus arteriosus in dogs(Mdpi, 2022-12-01) Shimada, Kazumi; Hamabe, Lina; Hirose, Miki; Watanabe, Momoko; Yokoi, Aimi; Takeuchi, Aki; Ozai, Yusuke; Yoshida, Tomohiko; Takai, Shinji; Jin, Denan; Kocatürk, Meriç; Uehara, Katsumi; Tanaka, Ryou; KOCATÜRK, MERİÇ; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; V-5578-2017Simple Summary Chymase is a type of protease associated with tissue injury, inflammation, and the remodeling of the cardiovascular system. Chymase has been suspected to increase with the progression of cardiovascular diseases. The measurement of chymase activity can only be taken at the time of cardiovascular failure and requires tissue sampling. Therefore, chymase has not been examined in both human and veterinary medicine. In the present study, chymase activity was measured by using plasma from dogs diagnosed with patent ductus arteriosus, a commonly observed congenital heart disease condition in dogs. Moreover, as patent ductus arteriosus can be treated surgically, chymase activity was also measured in the post-operation plasma. The results of the present study showed that chymase activity could be measured from plasma in dogs with patent ductus arteriosus, and a decreased chymase activity was observed with an improvement in hemodynamics due to the surgical treatment. These new findings provide important information about the chymase mechanism in the field of veterinary medicine. In the future, chymase activity may be necessary for routine examinations of cardiac disorders in veterinary medicine. Chymase is a protease stored in mast cell granules that produces angiotensin II (ANG II) from angiotensin I (ANG I) and is associated with tissue injury, inflammation, and remodeling, especially involving the cardiovascular system. As cardiovascular events occur, chymase is activated by degranulation to the extracellular matrix. Although chymase has been suggested to be associated with cardiovascular disease progression, there are not enough reports in veterinary medicine. Patent ductus arteriosus (PDA) is a common congenital cardiac disease in veterinary medicine. Almost all cases of PDA can be treated surgically to prevent the development of congestive heart disease and/or pulmonary hypertension. The aims of the present study were to measure chymase activity before and after PDA occlusions, and to investigate the relationships between the congestive and hemodynamic states of PDA and chymase activity. In the present study, 17 puppies diagnosed with PDA were included and all puppies completely recovered to the level of healthy dogs. Chymase activity significantly decreased at 2 months after the operation, along with the echocardiography parameters of congestion. Therefore, plasma chymase activity may be useful as a novel predictor for understanding the hemodynamics of PDA in veterinary medicine.Publication A case of a complete atrioventricular canal defect in a ferret(Bmc, 2021-01-22) Agudelo, Carlos F.; Jekl, Vladimir; Hauptman, Karel; Crha, Michal; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0001-8320-1286; 0000-0002-2849-1222; V-5578-2017BackgroundAtrioventricular canal defect is a rare congenital disorder of the heart and describes the presence of an atrial septal defect, a variable presentation of ventricular septal alterations including ventricular septal defect malformations in the mitral and tricuspid valves. The defect has been described in human beings, dogs, cats, pigs, and horses.Case presentationThis paper describes the case of a complete atrioventricular canal defect in a four-year-old intact male pet ferret (Mustela putorius furo), which was presented due to posterior weakness, ataxia, and decreased appetite. A loud systolic murmur, dyspnea, and hind limb paraparesis were detected during the clinical examination. Thoracic radiographs showed generalized cardiomegaly and lung edema. ECG showed sinus rhythm with prolonged P waves and QRS complexes. Echocardiography showed a large atrial septal defect, atrioventricular dysplasia, and a ventricular septal defect. Palliative treatment with oxygen, furosemide, spironolactone, enalapril, diltiazem, and supportive care was chosen as the therapy of choice. The ferret recovered gradually during hospitalization. A follow-up examination at three and six months showed stabilization of cardiac function.ConclusionsTo the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret.Publication Effect of pimobendan in the treatment of pulmonary hypertension in a cat with giant right atrium(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-09-01) Tanaka, Ryou; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Veteriner Fakültesi; Dahiliye Ana Bilim Dalı; 0000-0002-2849-1222; 0000-0001-9836-0749; V-5578-2017; A-9637-2008Publication Extramedullary pulmonary plasmacytoma in a dog(Sciendo, 2019-06-01) İpek, Volkan; ACAR, HİLAL; KOCATÜRK, MERİÇ; Kocatürk, Meriç; Salcı, Hakan; SALCI, HAKAN; Sönmez, Gürsel; SÖNMEZ, GÜRSEL; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; 0000-0002-2849-1222; 0000-0002-2524-3274; JPN-6878-2023; AAP-7233-2020; V-5578-2017In this case report we are presenting a rare case of primary pulmonary plasmacytoma in a dog in the context of clinical and pathological findings. A six-years-old, female Rottweiler was brought to the clinic with respiratory complaints. The patient was dyspneic and tachypneic, and there were friction sounds on auscultation of the lungs. Laryngeal and tracheal palpation induced severe cough. Lateral and ventrodorsal radiographs of the thorax showed increased opacity in the lungs and loss of cardiac silhouette. Based on clinical and radiological findings, diagnosis of a lung mass was made and surgery recommended. Under general anesthesia, bilobectomy of the right lung lobes by medial sternotomy was performed. Upon cytological and histopathological findings, plasmacytoma was diagnosed.Publication Unilateral ovariohysterectomy due to incarcerated uterine horn in a pregnant ewe with ventral hernia(Mezogazda Kiado Kft, 2020-06-01) Intas, Kamil Seyrek; Kocaturk, Meric; KOCATÜRK, MERİÇ; Salci, Emsal Sinem Ozdemir; ÖZDEMİR SALCI, EMSAL SİNEM; Veteriner Fakültesi; 0000-0002-2849-1222; V-5578-2017; AAH-5294-2021Background: Ventral hernias are commonly diagnosed is ewes and other animals, which are likely to occur during pregnancy, due to the increased abdominal content. Hernias in pregnant animals might contain the uterus with dead or live foetus inside. Caesarean section and ovariohysterectomy can be indicated to solve these cases. In case of unilateral ovariohysterectomy, fertility of the animal can be preserved.Objectives: The aim of this article is to present a case, where unilateral ovariohysterectomy was performed on a pregnant ewe which had ventral hernia containing one uterine horn and a dead foetus inside, however the other uterine horn had a viable foetus in the abdomen.Case presentation: A 5-year-old, curly-fleeced breed, pregnant (at 145th day) ewe was presented with the complaint of recumbency, anorexia and focal abdominal swelling. On physical examination the swelling was 30 cm in diameter on the ventral abdomen. Palpation of the swelling was painful and contained a herniated uterine horn with the incarcerated head and extremities of a foetus. Ultrasonography confirmed the dead foetus in the incarcerated uterine horn but the foetus in the other uterine horn was alive. Under general anaesthesia, caesarean section was performed with routine lateral abdominal approach. Appearance of the uterine horn in the hernial sac was ischemic and showed necrosis. Following uterine incision, a dead foetus, necrotic uterine content and placentomes were observed. Considering further fertility of the ewe, unilateral ovariohysterectomy was performed, because the other uterine horn contained a viable foetus inside. The ewe and its newborn lamb were discharged without any complication.Conclusion: Unilateral ovariohysterectomy can be a useful tool in the management of ventral hernias in ewe, when the aim is to preserve the animal's fertility.Publication Serum proteomic changes in dogs with different stages of chronic heart failure(Mdpi, 2022-02-01) Sarıl, Ahmet; Kocatürk, Meriç; Shimada, Kazumi; Uemura, Akiko; Akgün, Emel; Levent, Pınar; Baykal, Ahmet Tarık; Prieto, Alberto Munoz; Agudelo, Carlos Fernando; Tanaka, Ryou; Ceron, Jose Joaquin; Koch, Jorgen; Yılmaz, Zeki; SARIL, AHMET; KOCATÜRK, MERİÇ; Levent, Pınar; YILMAZ, ZEKİ; Veteriner Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0001-9836-0749 ; T-4585-2019; V-5578-2017; DDR-1481-2022; A-9637-2008Simple Summary Canine MMVD is a progressive chronic disease with variable clinical signs, with some patients remaining completely asymptomatic while others develop CHF. Here, the aims of the pilot study were to evaluate serum proteins by proteomic analysis in dogs at different stages of chronic heart failure (CHF) due to degenerative mitral valve disease (MMVD), and how these proteins can change after a conventional treatment. Study revealed 157 different proteins; 11 were up- and 21 down-regulated at a statistically significant level in dogs with CHF compared to controls. Based on the bioinformatic analysis, protein-protein interactions between complement proteins, fibrinogen subtypes and others (albumin precursor, serpins, inter-alpha-trypsin inhibitor heavy chain, fetuin, clusterin, apolipoproteins, and alpha-glycoproteins) showed that pathophysiology of CHF seems to be more sophisticated than we had thought. These proteins are associated with several cellular, biologic, and metabolic processes such as immune-inflammatory responses, hemostasis, oxidative stress, and energy metabolism, which might be detrimental in the progression of canine CHF. Their molecular and biological functions as well as roles in the signaling pathways, such as inflammation, cadherin signaling, nicotinic acetylcholine receptor signaling and Wnt signaling make them possible biomarkers and therapeutic targets for the diagnosis and treatments in dogs with different stages of CHF. MMVD, the most common cause of CHF in dogs, is a chronic disease with variable clinical signs, with some patients remaining asymptomatic while others develop CHF. Here, we aimed to evaluate serum proteins by proteomic analysis in dogs at different stages of CHF due to MMVD, and proteome behaviors after conventional treatment. A total of 32 dogs were divided equally into four groups-stage A (healthy/controls), stage B2 (asymptomatic), stage C and stage D (symptomatic)-according to the ACVIM consensus. Serum proteomes were evaluated using LC/MS-based label-free differential proteome analysis. The study revealed 157 different proteins; 11 were up- and 21 down-regulated in dogs with CHF compared to controls. In stage B2 dogs, angiotensinogen (AGT) was up-regulated, but immunoglobulin iota chain-like, lipopolysaccharide-binding protein, and carboxypeptidase (CPN) were down-regulated. In stage C dogs, complement C3 (C3) and inter-alpha-trypsin inhibitor heavy chain were up-regulated, but hemopexin, and actin-cytoplasmic-1 (ACT-1) were down-regulated. In stage D dogs, AGT was up-regulated, whereas tetranectin, paraoxonase-1, adiponectin and ACT-1 were down-regulated. A decrease in CPN, C3 and AGT and an increase in ACT-1 were observed after treatment of dogs in stage C. This pilot study identified that dogs at different stages of CHF show different serum protein composition which has potential to be biomarker for diagnose and treatment monitorization.Publication Chylothorax associated with ebstein's anomaly in a golden retriever dog(Ankara Üniversitesi, 2015-01-01) Yılmaz, Zeki; Levent, Pınar; Kocatürk, Meriç; Cihan, Hüseyin; Pars, Elif; Sağ, Saim; YILMAZ, ZEKİ; Levent, Pınar; KOCATÜRK, MERİÇ; CİHAN, HÜSEYİN; Sağ, Saim; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0001-9836-0749; 0000-0002-2849-1222; 0000-0003-1544-6438; 0000-0001-8404-8252; ABH-3742-2020; V-5578-2017; AAW-9185-2020; A-9637-2008; DDR-1481-20222-year-old, intact female, a Golden Retriever Dog was presented with the signs of respiratory distress, exercise intolerance, and muscular weakness. A high-grade systolic murmur was auscultated over the tricuspid valvular area. Thoracic radiographs showed an enlarged D-shape heart and free fluid (chylothorax) in the pleural space. ECG revealed small QRS complexes. Doppler echocardiography disclosed severe tricuspid insufficiency with moderate pulmonary hypertension, and tricuspid leaflets also were displaced down into the right ventricle, substantiating Ebstein's anomaly. Five-weeks after the medical therapy, patient died at home. The owner of the patient refused the necropsy. This is the first case report of tricuspid dysplasia and Ebstein's anomaly along with chylothorax in dogs.