Person: KOCATÜRK, MERİÇ
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KOCATÜRK
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MERİÇ
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Publication Effect of pimobendan in the treatment of pulmonary hypertension in a cat with giant right atrium(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020-09-01) Tanaka, Ryou; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; V-5578-2017; A-9637-2008Publication A case of a complete atrioventricular canal defect in a ferret(Bmc, 2021-01-22) Agudelo, Carlos F.; Jekl, Vladimir; Hauptman, Karel; Crha, Michal; Kocatürk, Meriç; KOCATÜRK, MERİÇ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-8320-1286; 0000-0002-2849-1222; V-5578-2017BackgroundAtrioventricular canal defect is a rare congenital disorder of the heart and describes the presence of an atrial septal defect, a variable presentation of ventricular septal alterations including ventricular septal defect malformations in the mitral and tricuspid valves. The defect has been described in human beings, dogs, cats, pigs, and horses.Case presentationThis paper describes the case of a complete atrioventricular canal defect in a four-year-old intact male pet ferret (Mustela putorius furo), which was presented due to posterior weakness, ataxia, and decreased appetite. A loud systolic murmur, dyspnea, and hind limb paraparesis were detected during the clinical examination. Thoracic radiographs showed generalized cardiomegaly and lung edema. ECG showed sinus rhythm with prolonged P waves and QRS complexes. Echocardiography showed a large atrial septal defect, atrioventricular dysplasia, and a ventricular septal defect. Palliative treatment with oxygen, furosemide, spironolactone, enalapril, diltiazem, and supportive care was chosen as the therapy of choice. The ferret recovered gradually during hospitalization. A follow-up examination at three and six months showed stabilization of cardiac function.ConclusionsTo the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret.Publication Choline or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock(Elsevier, 2021-10-27) Ozarda, Yesim; Ceron, Jose Joaquin; Buturak, Ali; Ulus, Ismail H.; Kocaturk, Meric; KOCATÜRK, MERİÇ; Yilmaz, Zeki; YILMAZ, ZEKİ; Cansev, Mehmet; CANSEV, MEHMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-2849-1222; 0000-0001-9836-0749; 0000-0003-2918-5064; 0000-0002-8654-1793; H-9043-2015; D-5340-2015; V-5578-2017; A-9637-2008Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5 '-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDPcholine on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-alpha), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pO2 and pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-alpha, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting.Publication Unilateral ovariohysterectomy due to incarcerated uterine horn in a pregnant ewe with ventral hernia(Mezogazda Kiado Kft, 2020-06-01) Intas, Kamil Seyrek; Kocaturk, Meric; KOCATÜRK, MERİÇ; Salci, Emsal Sinem Ozdemir; ÖZDEMİR SALCI, EMSAL SİNEM; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-2849-1222; V-5578-2017; AAH-5294-2021Background: Ventral hernias are commonly diagnosed is ewes and other animals, which are likely to occur during pregnancy, due to the increased abdominal content. Hernias in pregnant animals might contain the uterus with dead or live foetus inside. Caesarean section and ovariohysterectomy can be indicated to solve these cases. In case of unilateral ovariohysterectomy, fertility of the animal can be preserved.Objectives: The aim of this article is to present a case, where unilateral ovariohysterectomy was performed on a pregnant ewe which had ventral hernia containing one uterine horn and a dead foetus inside, however the other uterine horn had a viable foetus in the abdomen.Case presentation: A 5-year-old, curly-fleeced breed, pregnant (at 145th day) ewe was presented with the complaint of recumbency, anorexia and focal abdominal swelling. On physical examination the swelling was 30 cm in diameter on the ventral abdomen. Palpation of the swelling was painful and contained a herniated uterine horn with the incarcerated head and extremities of a foetus. Ultrasonography confirmed the dead foetus in the incarcerated uterine horn but the foetus in the other uterine horn was alive. Under general anaesthesia, caesarean section was performed with routine lateral abdominal approach. Appearance of the uterine horn in the hernial sac was ischemic and showed necrosis. Following uterine incision, a dead foetus, necrotic uterine content and placentomes were observed. Considering further fertility of the ewe, unilateral ovariohysterectomy was performed, because the other uterine horn contained a viable foetus inside. The ewe and its newborn lamb were discharged without any complication.Conclusion: Unilateral ovariohysterectomy can be a useful tool in the management of ventral hernias in ewe, when the aim is to preserve the animal's fertility.Publication Ventricular septal defect and pulmonic stenosis in a dog(Kafkas Univer, Veteriner Fakultesi Dergisi, 2019-09-01) Uemura, Akiko; Tanaka, Ryou; Yılmaz, Zeki; YILMAZ, ZEKİ; Levent, Pınar; Sarıl, Ahmet; SARIL, AHMET; Kocatürk, Meriç; KOCATÜRK, MERİÇ; 0000-0001-9836-0749; 0000-0003-2671-5074; 0000-0002-2849-1222; 0000-0001-9948-6490; V-5578-2017; M-3078-2019; T-1481-2019; A-9637-2008Publication Changes in choline and cholinesterase in saliva of dogs with parvovirus infection(Elsevier, 2021-01-01) Kocatürk, Meriç; Tecles, Fernando; Yalçın, Ebru; Cihan, Hüseyin; Tural, Merve; Levent, Pınar; Cansev, Mehmet; Ceron, Jose J.; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YALÇIN, EBRU; CİHAN, HÜSEYİN; Tural, Merve; Levent, Pınar; CANSEV, MEHMET; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-6703-4908; 0000-0003-2918-5064; 0000-0001-9836-0749; M-9071-2019; GDR-9018-2022 ; V-5578-2017; ACP-9956-2022; A-9637-2008; ABH-3742-2020; DDR-1481-2022This study investigated the changes in choline (Ch) and butyrylcholinesterase (BChE) in saliva in canine parvovirosis (CP) as a model of sepsis, and their correlations with these analytes in serum and with other markers of inflammation such as white blood cell count (WBC) and serum C-reactive protein (CRP). A total of 30 dogs with CP were sampled for saliva and serum at presentation, and 10 healthy puppies were also sampled as controls. Salivary Ch was higher in dogs with CP (P < 0.001) showing a positive correlation with CRP, whereas no differences were observed in salivary BChE. This is the first report in which Ch is measured in saliva of dogs and based in the results of this study, salivary Ch could be potentially used as biomarker of the severity of CP.